Orlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female Rats

Hameed, Haneen Mushtaq; Hasan, Ahmed Flayyih; Razooki, Zainab Haytham; Tousson, Ehab; Fatoh, Shahenda Anter

doi:10.3844/ojbsci.2023.25.32

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…The liver and brain tissues of all groups were excised, fixed in 10% formalin for a period between (24-48 hours), dehydrated in ascending alcohol concentrations, paraffin wax infiltrated and then were cut at 5 m sections to be mounted on glass slides. Then, the slide tissue sections were deparaffinized and hydrated again then stained with hematoxylin and eosin (H&E) for histological examination by light microscopy according to Hameed et al (2022) andFatoh et al (2023).…”

Section: Immunohistochemical Investigationmentioning

confidence: 99%

Effect of treatment with essential oils on the liver toxicity induced by Ehrlich ascites carcinoma in female mouse model

Hameed,

Hasan,

Razooki

et al. 2024

Egyptian Journal of Cancer and Biomedical Research

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Background: Essential oils (SO) are organic substances that are extracted from plant parts, which have been thought to have anti-cancer characteristics. Aim: To investigate the potential protective effects of SO against liver toxicity induced in EAC-bearing female mice. Materials and Methods: Forty female mice were equally divided into four groups (Gps). Gp1 was served as control, Gp2 was treated with SO, Gp3 was inoculated with EAC, and Gp4 were concomitantly treated with EAC + SO. Results: Data showed that the treatment of EAC-bearing mice with SO led to an amelioration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities. SO treatment also induced increases in the total protein levels as compared to EAC group. There was a significant improvement in the expression of GFAP protein in brain and liver tissues in the EAC/SO treated group as compared to the EAC group. Conclusion: The current results indicate to the potential hepatoprotective effects of essential oils.

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Section: Immunohistochemical Investigationmentioning

confidence: 99%

Effect of treatment with essential oils on the liver toxicity induced by Ehrlich ascites carcinoma in female mouse model

Hameed,

Hasan,

Razooki

et al. 2024

Egyptian Journal of Cancer and Biomedical Research

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Efficacy and Bioavailability of silymarin on Plasma S100B Level in Cardiotoxicity-induced Rats

Jalil,

Altaei

2024

Biomed. Pharmacol. J.

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Cardiotoxicity is a cause of death by drug overdose. Silymarin, a cytoprotective agent used in this research to protect against induced-cardiotoxic effects in Albino Wister rats; exhibited signs of heart damage, such as elevated levels of S100B, troponin I, and CK-MB. Seventy albino Wister rats of both genders were divided randomly with each group having 10 rats. Silymarin-treated, cardiotoxic-induced, and control groups were treated for ten days. The bioavailability of silymarin was assessed, and evaluation of the efficacy of silymarin on the biomarker S100B and cardiac biomarkers (Troponin I, and CK-MB), also the histopathological assessments of the heart, liver, and kidney, in addition to the coefficient correlation of the studied biomarkers were analyzed. Research’s outcome indicated that the sets subjected to silymarin presented substantial differences in rat weight and food consumption, compared to a decrease in cardiotoxic clusters. S100B plasma level was increased in cardiotoxic groups, reduced in those subjected to silymarin, and eliminated by pretreatment with silymarin. Troponin I & CK-MB expressively elevated significantly in cardiotoxic prompted rats, which declined with silymarin treatment and were prohibited in pretreatment by silymarin. The shielding characteristic of silymarin detected in end organs, like the liver, kidneys, and hearts when exposed to the cardiotoxic agent clozapine was extremely significant. The consequences of the histopathological examination of this study illustrated silymarin’s cardioprotective effects. A significant positive coefficient correlation of S100B with troponin I & CK-MB was recorded. In conclusion, silymarin reduces and prevents to a larger extent the cardiotoxicity brought about by clozapine and averts heart injury. The cardioprotective efficacy of silymarin is explained by its new mechanism of action as decreasing S100B, troponin I & CK-MB levels with a strong significant correlation to each other. The cardioprotective efficacy of silymarin gives promise for monitoring the cardiotoxicity adverse drug reaction induced by drugs.

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Effect of Artemisia Vulgaris on Liver of Albino Mice Exposed to Cisplatin

Abbood,

Faisal,

Al-Imam

2024

Biomed. Pharmacol. J.

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The herb Arte(also known as Artemisia V.) is widely used to treat a variety of illnesses, including gastrointestinal disorders, infections, and fungal infections. The antibacterial component that makes this ingredient so beneficial and essential for treating septicemia is the prebiotic. This study looked at how Artemisia vulgaris L. protected rats' livers from the toxic treatment cisplatin. In virtual medicine, cisplatin is frequently employed. Numerous forms of human cancer, such as advanced cancer, uterine cancer, esophageal cancer, advanced privacy, and ovarian cancer, have been successfully treated with it. infection from other illnesses, like disease. In this experiment, thirty 25–30 g white secretive mice aged 12 weeks were used. 72 hours were spent soaking blood tissue samples in 4% paraformaldehyde before they were paraffin embedded. Hematoxylin-eosin (H, E) staining was applied after the sections were cut into 3-m pieces and embedded in paraffin wax. Establishing with the extraction of Artemisia vulgaris L 400 mg/kg/day of extract is the greatest efficiency technique, as the separated groups revealed. This proved the extract's efficiency. This finding offers thorough and widely reported support for the use of purifications like A. vulgaris in the medical treatment of systemic poisoning with additional benefits like definite therapeutic effects and potent histochemical in the treatment of cancerous tissues.

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Orlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female Rats

Cited by 3 publications

References 34 publications

Effect of treatment with essential oils on the liver toxicity induced by Ehrlich ascites carcinoma in female mouse model

Effect of treatment with essential oils on the liver toxicity induced by Ehrlich ascites carcinoma in female mouse model

Efficacy and Bioavailability of silymarin on Plasma S100B Level in Cardiotoxicity-induced Rats

Effect of Artemisia Vulgaris on Liver of Albino Mice Exposed to Cisplatin

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