Orodispersible tablets: an overview

Kakar, Satinder; Ram,; Singh, eep; Kumar, Sanjay

doi:10.15406/mojpb.2018.07.00230

Cited by 6 publications

(5 citation statements)

References 1 publication

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“…As a result of holes in the tablet's structure created by the sublimation of volatile substances, tablets dissolve when they come into contact with saliva. Furthermore, a variety of solvents, including as benzene and cyclohexane, may be used as pore-forming agents [12]. Fig.…”

Section: Orasolv Technologymentioning

confidence: 99%

An Overview on Mouth Dissolving Tablet: From Manufacturing and Patented Technique to Quality Control Test

PREETI¹,

AGARWAL²,

AGARWAL³

2022

Asian J Pharm Clin Res

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Due to the oral route’s comfort, convenience, and patient compliance, it is the most important and advised method for administering medications. The typical oral unit dosage form that is most frequently employed is the tablet. The patients experience problems swallowing during pill administration. Tablets called mouth dissolving tablets (MDTs) that quickly dissolve in the mouth without the need of water can lessen this issue. As a new drug delivery system, MDTs have begun to acquire recognition and appeal. By developing a simple-to-use dosage form that will increase compliance, they hope to increase the safety and efficiency of therapeutic molecules. For individuals with dysphasia, such as children, the elderly, and those who are mentally ill, mouth dispersing medications are becoming more reliable. The introduction, benefits, drawbacks, excipients employed, different formulation procedures, and evaluation factors are all covered in this review.

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Section: Orasolv Technologymentioning

confidence: 99%

An Overview on Mouth Dissolving Tablet: From Manufacturing and Patented Technique to Quality Control Test

PREETI¹,

AGARWAL²,

AGARWAL³

2022

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…For manufacturing ODTs, multiple technologies can be used: some conventional (direct compression, freeze-drying, tablet molding, spray-drying, sublimation) and some patented technologies highlighted in Table 1 (Zydis ® , Orasolv ® , Durasolv ® ) [4,5]. Direct compression is the easiest and most cost-effective of all methods, using a conventional tablet press for manufacturing, while the disintegrating process is assured by disintegrants or superdisintegrant excipients.…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Intergranular Superdisintegrant Performance on New Drotaverine Orodispersible Tablet Formulations

Vlad,

Pintea,

Chirteș

et al. 2023

Pharmaceutics

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The main objective of this study consists in establishing the influence of the intergranular superdisintegrant on the specific properties of drotaverine hydrochloride fast-dissolving granules (DROT-FDGs) and orodispersible tablets (DROT-ODTs). The orodispersible tablets were obtained by the compression of the FDGs and excipient mixture with an eccentric tableting machine. To develop DROT-ODTs, two types of superdisintegrant excipients in different concentrations (water-soluble soy polysaccharides (SSP) (1%, 5%) and water-insoluble soy polysaccharides—Emcosoy® STS IP (EMCS) (1%, 3%, 5%)) were used, resulting in five formulations (D1–D5). The DROT-FDGs and the DROT-ODTs were subjected to pharmacotechnical and analytical evaluation. All the orodispersible tablets obtained respect the quality requirements in terms of friability (less than 1%), crushing strength (ranging between 52 N for D2 and 125.5 N for D3), and disintegration time (<180 s). The in vitro release of drotaverine from ODTs showed that all formulations presented amounts of active substance released greater than 85% at 10 min. The main objective, developing 30 mg DROT-ODTs for children aged between 6 and 12 years by incorporating the API in FDGs, was successfully achieved.

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“…The United States Pharmacopoeia (USP) has designated these dosage forms as ODTs, based on the foregoing. The word Orodispersible tablet was invented by the European Pharmacopoeia to describe tablets that spread easily in the mouth within 3 minutes before being swallowed (Anjan et al, 2013;Kakar, 2018).…”

Section: Introductionmentioning

confidence: 99%

Design, development and in vivo pharmacokinetic of telmisartan loaded oral disintegration tablets

Chatterjee

Abdulla

Nagarajan

et al. 2020

ijrps

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Orodispersible Tablets (ODT) is a novel tableting technology which is formulated, and it overcomes the difficulties of other multi compressed tablets. Telmisartan has a bioavailability of 42-100 percent and a 24-hour elimination half-life. It excretes the majority of drugs through the faeces, which accounts for 97 percent of total drug excretion. The objective of this research is to formulate and evaluate Telmisartan loaded ODT and to prove the enhancement of dissolution and bioavailability of Telmisartan. From the DSC studies, it was confirmed that Telmisartan and excipients used in the formulation are compatible to each other and suitable for the manufacturing process. Telmisartan loaded ODT was formulated by wet granulation technique and evaluated for powder characteristics and release characteristics. About 9 formulations were formulated in each ODT, and all the formulation obeys a good powder flow characteristic from the angle of repose, Carr’s index and Hausner’s ratio. All the experimental formulation batches have been subjected to various evaluations viz, average weight, friability, disintegration, thickness, hardness, dissolution, content uniformity. Among this nine Telmisartan ODT formulations (F1-F9), F7 possess an expected release pattern and disintegration time in a short time period (i.e., 101.8 ± 2.72 in 5th min and disintegration time at 5 seconds), which may fastens the absorption and bioavailability of Telmisartan. It was concluded that ODT was a suitable dosage form to enhance the solubility at the same time the bioavailability of BCS class II drugs like Telmisartan.

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Orodispersible tablets: an overview

Abstract: The oral route is the most widely accepted route. The review deals with overview of orodipersible tablets that includes advantages, disadvantages, properties, methods for its formulation.

Cited by 6 publications

References 1 publication

An Overview on Mouth Dissolving Tablet: From Manufacturing and Patented Technique to Quality Control Test

An Overview on Mouth Dissolving Tablet: From Manufacturing and Patented Technique to Quality Control Test

The Influence of the Intergranular Superdisintegrant Performance on New Drotaverine Orodispersible Tablet Formulations

Design, development and in vivo pharmacokinetic of telmisartan loaded oral disintegration tablets

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