Oroesophageal Pemphigus vulgaris Secondary to Lisinopril Use: A New Side Effect

Tariq, Usman; Nasrullah, Adeel; Guha, Aritra; Mitre, Marcia

doi:10.7759/cureus.14333

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Pemphigus vulgaris is recognized by "flaccid, mucous, or mucocutaneous blisters" [9]. With most affected individuals, the oral mucosa is primarily affected (with other mucous membranes sometimes involved as well).…”

Section: Discussionmentioning

confidence: 99%

Ocular Involvement in Pemphigus Vulgaris Without Skin Lesions: A Case Report

Majid¹,

Martel²,

Martel³

et al. 2022

Cureus

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Pemphigus vulgaris (PV) is an autoimmune disorder affecting the skin and mucous membranes. The condition may be confused with a number of disorders, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and erythema multiforme (EM), all of which are life-threatening. Immunohistological and histochemical analyses remain the optimal methods for differentiating these diseases. There is still insufficient evidence regarding the true incidence rate of ocular disease in PV as well as its distinct clinical types. This report sets to review the case of a 62-year-old male with atypical ocular pemphigus vulgaris and review the literature.

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Section: Discussionmentioning

confidence: 99%

Ocular Involvement in Pemphigus Vulgaris Without Skin Lesions: A Case Report

Majid¹,

Martel²,

Martel³

et al. 2022

Cureus

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“…Most of the commonly prescribed diuretics fall under this category. Known drugs include Cilazapril, fosinopril, lisinopril, nifedipine, imiquimod, carbamazepine, chloroquine/hydroxychloroquine, dipyrone, glibenclaimde, ingenol mebutate, acetazolamide, candesartan, ciprofloxacin, cocaine, diazinon, hydrochlorothiazide, irbesartan, methylisothiazolinone, metoprolol, phenytoin ( 11 , 20 , 27 – 29 , 32 – 41 , 44 , 45 ). These groups (sulfur and amides) are postulated to induce PV via immunological mechanisms that stimulate keratinocytes to produce proinflammatory cytokines such as TNF and IL-1 ( 8 , 55 – 57 ), leading to the activation of proteases and complement that contribute to acantholysis.…”

Section: Findings On Environmental and Lifestyle “Exposome” Factorsmentioning

confidence: 99%

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

et al. 2023

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Pemphigus vulgaris (PV) is a potentially life-threatening blistering disorder characterized by autoantibodies directed against cell-cell adhesion molecules that serves as an excellent model to study human autoimmune development. Numerous studies have identified specific Human Leukocyte Antigen (HLA) genes, in particular DRB1*0402 and DQB1*0503, that confer disease risk. Although HLA is required, it is not sufficient for the initiation of disease. As with all autoimmune diseases, the etio-pathogenesis of PV is complex, meaning it is multifactorial. Susceptibility is polygenic, and the search for non-HLA disease-linked genes continues. Moreover, twin studies across autoimmune conditions indicate that non-genetic environmental and lifestyle factors, which can be collectively grouped under the term “exposome”, are also major contributors to disease development. The literature presents evidence for the potential role of multiple triggers such as medications, infections, stress, diet, immunizations, and sleep to influence the etiology, pathophysiology, and prognosis of PV. However, a clear understanding of the degree to which specific factors impact PV is lacking. In this investigation, we comprehensively review the environmental elements listed above and consider the strength of evidence for these factors. The overall goals of this work are to provide greater insights into the factors that influence disease susceptibility, disease development and disease course and ultimately help to better guide clinicians and inform patients in the management of PV.

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Case Report: Angiotensin converting enzyme inhibitors vs. angiotensin receptor blockers in the management of chronic hypertension: a case of lisinopril-induced rhinorrhea

Amudzi,

Samale,

Vela-Parada

2024

Front. Allergy

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A 47-year-old woman presents to our clinic with a chief complaint of rhinorrhea; she had chronic hypertension managed with four antihypertensive drugs, including an ACE inhibitor. While dry cough is a well-known side effect associated with ACE inhibitors, this case highlights a common chief complaint yet less recognized side effect of ACE inhibitors and further emphasizes the idea that overall, angiotensin receptor blockers may be a better drug of choice in hypertension due to their favorable side effect profile.

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Oroesophageal Pemphigus vulgaris Secondary to Lisinopril Use: A New Side Effect

Cited by 3 publications

References 18 publications

Ocular Involvement in Pemphigus Vulgaris Without Skin Lesions: A Case Report

Ocular Involvement in Pemphigus Vulgaris Without Skin Lesions: A Case Report

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

Case Report: Angiotensin converting enzyme inhibitors vs. angiotensin receptor blockers in the management of chronic hypertension: a case of lisinopril-induced rhinorrhea

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