Oropharyngeal and laryngeal but not oral cancers are strongly associated with high‐risk human papillomavirus in 172 Greek patients

Tsimplaki, Elpida; Argyri, Elena; Sakellaridis, Athanassios; Kyrodimos, Efthymios; Xesfyngi, Dimitra; Panotopoulou, Efstathia

doi:10.1002/jmv.24614

Cited by 14 publications

(13 citation statements)

References 46 publications

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“…In our cohort, the overall HPV DNA prevalence was 13.6%, with HPV 16 being the predominant genotype. This is comparable with previous studies where overall HPV DNA prevalence in LSCC was 13.5% . However, Xu et al reported a markedly lower HPV infection rate than in our current study, which is only 4.9%.…”

Section: Discussionsupporting

confidence: 89%

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Association study of cell cycle proteins and human papillomavirus in laryngeal cancer in Chinese population

Cui

Liu

2019

Clinical Otolaryngology

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Objective To investigate the role of human papillomavirus (HPV) in laryngeal squamous cell carcinoma (LSCC) and analyse the relationship between HPV and the expression of cell cycle‐related proteins. Design The study consisted of LSCC between 2005 and 2011 in Tongren Hospital. Clinical data such as age, sex, smoking/alcohol consumption, and TNM stage were collected. HPV DNA and cell cycle‐related proteins were assessed in terms of clinical features. Setting Single‐centre study. Participants A total of 332 LSCC patients were included in the study. Main outcome measures The presence of genotype‐specific HPV DNA was evaluated using PCR‐RDB in formalin‐fixed paraffin‐embedded tissues. All samples were also evaluated for p16INK4A, p21WAF1/CIP1, P53, Cyclin D1, and Ki67 immunohistochemical staining by tissue microarray. Results HPV DNA was detected in 45 of 332 (13.55%) patients with LSCC, with HPV‐16 being the predominant genotype. The presence of HPV‐16 DNA was significantly associated with basaloid squamous cell carcinoma and cystic lymph node metastasis (P < 0.05). Of the 332 patients, 36 (10.84%) were scored as p16INK4A positivity and they were more likely to be female (P < 0.05). Cyclin D1‐positivity and p21WAF1/CIP1‐positivity were observed in 60.24% (200/332) and 40.66% (135/332), respectively. In 114 cases (34.33%), LSCCs had moderate‐ to ‐strong p53 accumulation, which was correlated with TNM stage (P < 0.05). HPV‐16 DNA was correlated with p16INK4A and manifested a higher Ki‐67 labelling index and p21WAF1/CIP1 expression than HPV‐16‐negative tumours (P < 0.05). No relationship was observed between Cyclin D1or P53 expression and HPV‐16 infection (P > 0.05). Conclusion HPV DNA was detected in 13.55% patients with LSCC, with HPV‐16 being the predominant genotype and it was correlated with p16INK4A and manifested a higher Ki‐67 labelling index and p21WAF1/CIP1 expression than HPV‐16‐negative tumours.

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Section: Discussionsupporting

confidence: 89%

“…TA B L E 2 Clinicopathological characteristics of patients and cell cycle-related proteins In our cohort, the overall HPV DNA prevalence was 13.6%, with HPV 16 being the predominant genotype. This is comparable with previous studies where overall HPV DNA prevalence in LSCC was 13.5% 11,13. However, Xu et al14 reported a markedly lower HPV…”

supporting

confidence: 90%

Association study of cell cycle proteins and human papillomavirus in laryngeal cancer in Chinese population

Cui

Liu

2019

Clinical Otolaryngology

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“…HPV infection has been shown to cause oropharyngeal cancer. The association between HPV and LSCC is based on the morphological similarities between the cervical and the squamous epithelium, as well as the detection of the commonest oncogenic HPV genotypes (HPV-16, HPV-18) in both cervical and laryngeal cancers (LC) [10,11]. However, the clinical significance of HPV infection remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

Combined Effect of HPV and Several Gene SNPs in Laryngeal Cancer

Stumbrytė-Kaminskienė

Gudlevičienė

Dabkevičienė

et al. 2020

Medicina

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Background and objectives: Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck tumors. The molecular mechanism of LSCC remains unclear. The aim of this study was to evaluate the prevalence of Human papillomavirus (HPV) and single nucleotide polymorphisms (SNPs) of TP53, MDM2, MDM4, MTHFR, CASP8, and CCR5 genes in LSCC, and to assess their correlations with patient survival. Materials and Methods: 49 LSCC patients were enrolled in this study. PCR and qRT-PCR were used to detect, identify, and quantify HPV. SNPs were genotyped using PCR and PCR-RFLP. Results: By analyzing the interactions of the SNPs of the genes with clinical parameters, the majority of patients with lymph node status (N1,2) were identified as carriers of MDM2 T/G, CASP8 ins/del, CCR5 wt/wt SNP. Cluster analysis showed that patients with MDM2 T/T SNP survive longer than patients identified as CASP8 ins/ins, MTHFR C/C, and MDM4 A/A variant carriers; meanwhile, LSCC patients with MDM2 T/T polymorphic variant had the best survival. Multivariate analysis showed that HPV-positive patients without metastasis in regional lymph nodes (N0) and harboring CASP8 ins/del variant had the best survival. Meanwhile, HPV-negative patients with identified metastasis in lymph nodes (N1 and N2) and CASP8 ins/del variant had poor survival. Conclusions: This finding suggests patients survival prognosis and tumor behavior are different according HPV status, SNP variants, and clinical characteristics of the LSCC.

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“…Laryngeal cancer can result from the combined action of smoking, drinking, air pollution, HPV infection and sex hormone levels. Recently, increasing studies have found that among the many pathogenic factors of laryngeal cancer, high-risk HPV (HR-HPV) infection may be one of the most important 2, 3. Epidemiological studies reported HPV infection rates in laryngeal cancer ranging from 8% to 83% 3, 4; a meta-analysis showed a 28% HPV infection rate in all LSCC 3, and HPV infection was correlated with its occurrence 5.…”

Section: Introductionmentioning

confidence: 99%

Effect of HPV Infection on the Occurrence and Development of Laryngeal Cancer: A Review

Yang¹,

Shi²,

Tang³

et al. 2019

J. Cancer

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Laryngeal cancer has the second highest incidence of head and neck malignant tumors worldwide. In recent years, studies have shown that human papillomavirus (HPV) infection may be a high-risk factor for laryngeal cancer and closely related to the development and prognosis of laryngeal cancer. The mechanism of the occurrence and development of laryngeal cancer caused by HPV infection needs investigation, as does a rapid and effective HPV detection method for effectively preventing the occurrence of laryngeal cancer and controlling its development. Many studies have explored the relation between HPV infection and laryngeal cancer. Here we review the research progress in investigating HPV infection in terms of DNA, mRNA and protein levels in the occurrence and development of laryngeal cancer and routine HPV detection methods.

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Oropharyngeal and laryngeal but not oral cancers are strongly associated with high‐risk human papillomavirus in 172 Greek patients

Cited by 14 publications

References 46 publications

Association study of cell cycle proteins and human papillomavirus in laryngeal cancer in Chinese population

Association study of cell cycle proteins and human papillomavirus in laryngeal cancer in Chinese population

Combined Effect of HPV and Several Gene SNPs in Laryngeal Cancer

Effect of HPV Infection on the Occurrence and Development of Laryngeal Cancer: A Review

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