Oropharyngeal histoplasmosis: The diagnosis lies in the biopsy

Miranda, Claudia; Jaker, Michael; Fitzhugh-Kull, Valerie A.; Dever, Lisa L.

doi:10.1016/j.idcr.2017.12.005

Cited by 8 publications

(7 citation statements)

References 9 publications

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“…Histoplasmosis caused by Histoplasma capsulatum usually occurs after exposure to bird and bat guano [ 6 ]. After inhalation of microconidia, it may cause pulmonary involvement, presenting as pneumonia, or may remain asymptomatic [ 7 ]. However, immunodeficiency patients can develop a disseminated disease involving the bone marrow, adrenal glands, gastrointestinal system, and reticuloendothelial system [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Disseminated Histoplasmosis With Hemophagocytic Syndrome in a Patient With Diabetes Mellitus: A Case Report

Gupta¹,

KL²,

Totaganti³

et al. 2023

Cureus

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We report a case of Histoplasma-associated hemophagocytic syndrome in a diabetes mellitus patient. The patient presented with a fever, cough, and an ulcer on the tongue. The biopsy confirmed the diagnosis of histoplasmosis from the tongue ulcer. Other investigations revealed normal clusters of differentiation 4 (CD4) count and increased hemoglobin A1c (HbA1c) and lactate dehydrogenase (LDH) levels. The patient was diagnosed with hemophagocytic syndrome secondary to Histoplasma after fulfilling the hemophagocytic lymphohistiocytosis (HLH)-2004 criteria required for diagnosis, including fever (with peak temperatures of >38.5° C), splenomegaly, cytopenia affecting two cell lineages in peripheral blood, hypertriglyceridemia (fasting triglycerides >265 mg/dL), and hemophagocytosis in the bone marrow biopsy. The patient was started on injection amphotericin B with remarkable improvement.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Disseminated Histoplasmosis With Hemophagocytic Syndrome in a Patient With Diabetes Mellitus: A Case Report

Gupta¹,

KL²,

Totaganti³

et al. 2023

Cureus

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“…Only a single case (2.04 %) of nasopharyngeal masses was diagnosed as histoplasmosis 15 . Claudia Miranda et al 6 , in 2018, reported a case of a 79-yearold male presenting with odynophagia, dysphagia, fever and weight loss. The CT scan showed diffuse thickening of the oropharynx, supraglottic larynx, extending up to the vocal cords.…”

Section: Discussionmentioning

confidence: 99%

“…Histoplasmosis is found worldwide and is endemic in regions of Latin America and North America, Europe and few regions of Asia. In India, Histoplasmosis is endemic in Gangetic Delta of West Bengal and Assam 1,6 .…”

Section: Introductionmentioning

confidence: 99%

Histoplasmosis in nasopharynx clinically mistaken for nasopharyngeal malignancy

Pol¹,

Patil²,

Pol³

et al. 2023

Romanian Journal of Rhinology

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Histoplasmosis is a rare type of fungal infection which may manifest as a respiratory disease or as a disseminated infection. It is common in immunocompromised patients and, in recent times, seen in association with COVID-19. On histopathological examination, many intracellular and extracellular yeast forms are seen, which can be confirmed by fungal stains. Histoplasmosis involving the nasopharyngeal region is quite rare. Till date, only less than 100 cases of pharyngo-laryngeal histoplasmosis have been reported. Such cases are clinico-radiologically easily and frequently mistaken for malignancy. Here, we report a case that initially had COVID-19-like symptoms and later presented with a nasopharyngeal mass clinico-radiologically mistaken as a nasopharyngeal malignancy. The diagnosis was established on histopathological examination and the patient recovered completely with anti-fungal treatment. A high grade of suspicion and thorough histopathological examination, especially in immunocompromised patients, complimented by fungal special stains is quite rewarding as even a disseminated disease is curable.

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“…Histoplasmosis is a dimorphic fungus which is known to be widely distributed among western countries like America and in some parts of the tropical region. 1 In North America Histoplasma capsulatum is endemic to the Mississippi and Ohio River valleys but is also present in other areas. 2,3 There are two different type of fungus Histoplasma capsulatum var.…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal histoplasmosis– A rare case report

Sg¹,

K²,

K³

et al. 2021

JDPO

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Histoplasmosis is a dimorphic fungus which is widely distributed among western countries like America and in some parts of the tropical region. It is acquired by inhaling microconidia. Depending on the immune status patient may develop acute or chronic pulmonary diseases or disseminated infection. The disseminated form of nasopharyngeal region can present as ulceration, rhino sinusitis, nasal obstruction, dyspnoea, hoarseness of voice and clinically it can mimic carcinoma. Microscopically, the differential diagnosis of histoplasmosis includes Leishmaniasis, Cryptococci neoformans, Candida glabrata, Pneumocystis jiroveci and Penicillium marneffei infections. The diagnosis of histoplasma is dependent on histopathological examination and demonstration by special stains, where the latter serves the gold standard in demonstrating organism on light microscopy.

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Oropharyngeal histoplasmosis: The diagnosis lies in the biopsy

Cited by 8 publications

References 9 publications

A Rare Case of Disseminated Histoplasmosis With Hemophagocytic Syndrome in a Patient With Diabetes Mellitus: A Case Report

A Rare Case of Disseminated Histoplasmosis With Hemophagocytic Syndrome in a Patient With Diabetes Mellitus: A Case Report

Histoplasmosis in nasopharynx clinically mistaken for nasopharyngeal malignancy

Nasopharyngeal histoplasmosis– A rare case report

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