Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2

Li, Jihe; Tong, Dongxia; Liu, Juan; Chen, Fuyang; Shen, Yongbin

doi:10.1016/j.intimp.2016.10.011

Cited by 47 publications

(34 citation statements)

References 23 publications

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“…Macrophage activation has been reported to cause the airway inflammatory response via the release of inflammatory cytokines and chemokines, including IL-6, tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCP-1) (8,9). It is well understood that the activation of nuclear factor-κB (NF-κB) leads to the release of inflammatory cytokines and chemokines, including IL-6, IL-8, TNF-α and MCP-1 (10-12).…”

Section: Introductionmentioning

confidence: 99%

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

et al. 2019

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Pistacia weinmannifolia (PW) has been used in traditional Chinese medicine to treat headaches, dysentery, enteritis and influenza. However, PW has not been known for treating respiratory inflammatory diseases, including chronic obstructive pulmonary disease (COPD). The present in vitro analysis confirmed that PW root extract (PWRE) exerts anti-inflammatory effects in phorbol myristate acetate- or tumor necrosis factor α (TNF-α)-stimulated human lung epithelial NCI-H292 cells by attenuating the expression of interleukin (IL)-8, IL-6 and Mucin A5 (MUC5AC), which are closely associated with the pulmonary inflammatory response in the pathogenesis of COPD. Thus, the aim of the present study was to evaluate the protective effect of PWRE on pulmonary inflammation induced by cigarette smoke (CS) and lipopoly-saccharide (LPS). Treatment with PWRE significantly reduced the quantity of neutrophils and the levels of inflammatory molecules and toxic molecules, including tumor TNF-α, IL-6, IL-8, monocyte chemoattractant protein-1, neutrophil elastase and reactive oxygen species, in the bronchoalveolar lavage fluid of mice with CS- and LPS-induced pulmonary inflammation. PWRE also attenuated the influx of inflammatory cells in the lung tissues. Furthermore, PWRE downregulated the activation of nuclear factor-κB and the expression of phosphodiesterase 4 in the lung tissues. Therefore, these findings suggest that PWRE may be a valuable adjuvant treatment for COPD.

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Section: Introductionmentioning

confidence: 99%

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

et al. 2019

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“…Oroxylin A (5, 7‐dihydroxy‐6‐methoxyflavone, C 16 H 12 O 5 ), the active component of Scutellaria baicalensis , is one of the most important medicinal herbs in traditional Chinese medicine. Oroxylin A has been reported to have antioxidant, anti‐inflammation, anti‐cancer, antiviral and anti‐bacterial infections . Although oroxylin A has been reported to have anti‐hepatic injury effects, the hepatoprotective role of oroxylin A in alcoholic liver injury remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Oroxylin A inhibits ethanol‐induced hepatocyte senescence via YAP pathway

et al. 2018

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“…Treatment with antioxidants ameliorates the CS-induced neutrophil influx and airway inflammation through the induction of HO-1 (13). Li et al reported that antioxidants downregulate the expression of inflammatory cytokines and upregulate the expression of HO-1 in CSE-stimulated macrophages and bronchial epithelial cells (15). Therefore, HO-1 induction may be useful in the treatment of CS-induced airway inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Downregulation of extracellular signal-regulated kinase (ERK) reduces the production of inflammatory cytokines and chemokines in CS extract (CSE)-stimulated pulmonary epithelial cells and in animal models with CS-induced airway inflammation (13,14). The antioxidant defense protein heme oxygenase-1 (HO-1) exerts a protective effect against CS-induced lung inflammation (15). The levels of inflammatory cell influx and inflammatory molecules are decreased by HO-1 induction in animal models of CS-induced airway inflammation (16).…”

Section: Introductionmentioning

confidence: 99%

Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1

Park

Lee

Kwon

et al. 2017

International Journal of Molecular Medicine

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Physalis peruviana L. (PP) is a medicinal herb that has been confirmed to have several biological activities, including anticancer, antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the protective effect of PP on cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with PP significantly reduced the influx of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung of mice with CS- and LPS-induced pulmonary inflammation. PP also decreased the levels of reactive oxygen species (ROS) and pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the BALF. PP effectively attenuated the expression of monocyte chemoattractant protein-1 (MCP-1) and the activation of extracellular signal-regulated kinase (ERK) in the lung. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression were increased by PP treatment. In an in vitro experiment, PP reduced the mRNA expression of TNF-α and MCP-1, and the activation of ERK in CS extract-stimulated A549 epithelial cells. Furthermore, PP increased the activation of Nrf2 and the expression of HO-1 in A549 cells. These findings suggest that PP has a therapeutic potential for the treatment of pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease.

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Oroxylin A attenuates cigarette smoke-induced lung inflammation by activating Nrf2

Cited by 47 publications

References 23 publications

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

Oroxylin A inhibits ethanol‐induced hepatocyte senescence via YAP pathway

Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1

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