Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1

Abstract

Physalis peruviana L. (PP) is a medicinal herb that has been confirmed to have several biological activities, including anticancer, antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the protective effect of PP on cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with PP significantly reduced the influx of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung of mice with CS- and LPS-induced pulmonary inflammation. PP also decreased the levels of reactive oxygen species (ROS) and pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the BALF. PP effectively attenuated the expression of monocyte chemoattractant protein-1 (MCP-1) and the activation of extracellular signal-regulated kinase (ERK) in the lung. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression were increased by PP treatment. In an in vitro experiment, PP reduced the mRNA expression of TNF-α and MCP-1, and the activation of ERK in CS extract-stimulated A549 epithelial cells. Furthermore, PP increased the activation of Nrf2 and the expression of HO-1 in A549 cells. These findings suggest that PP has a therapeutic potential for the treatment of pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease.

Physalis peruviana L. Pulp Prevents Liver Inflammation and Insulin Resistance in Skeletal Muscles of Diet-Induced Obese Mice

“…PP calyces have already been reported to decrease nitric oxide and prostaglandin E2 in injection-induced λ-carrageenan paw edema in mice [29]. Inflammatory cytokines and chemokines were markedly decreased with PP leaf extract administration in a lipopolysaccharide (LPS)-induced inflammation airway model, in which the influx of inflammatory cells and the expression of monocyte chemoattractant protein-1 (MCP-1) in the inflamed lungs was reverted [19]. However, few reports have shown that PP fruits have anti-inflammatory effects [20]; our results add to the growing body of evidence showing that PP pulp decreases pro-inflammatory markers in the liver.…”

“…Physalis peruviana L. (PP) is distributed across South America; it is an abundant source of phenolic components, like coumarin, kaempferol, quercetin, and ascorbic acid, which have several biological activities including the prevention of some metabolic abnormalities associated with obesity [17]. Some of the beneficial effects of PP are described in different reports; PP extract reduced the formation of reactive oxygen species (ROS) and preserved mitochondrial membrane potential in astrocytes [18]; it attenuated airway inflammation associated with chronic obstructive pulmonary disease by inhibiting ROS production and activating antioxidant defense of the epithelial cells [19]. In the liver, the PP juice reduced CCl 4 -associated with liver injury, decreasing the lipoperoxidation level [20].…”

Physalis peruviana L. inhibits ovalbumin‑induced airway inflammation by attenuating the activation of NF‑κB and inflammatory molecules

“…The collected plant sample was identified by the Center for Pharmaceutical and Medical Technology (Tangerang, Indonesia), and authentication was confirmed by the Herbarium Bogoriense (Bogor, Indonesia). Voucher specimens were recorded as KRIB 0049496 and PMT 1884, which have been deposited in the herbarium of the Korea Research Institute of Bioscience and Biotechnology (Cheongju, Korea) and at the Center for Pharmaceutical and Medical Technology and Herbarium Bogoriense (18). Following drying and grinding of the leaves of the plant.…”

“…The levels of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages were found to be effectively downregulated by total extract from the calyces of PP (17). In our previous study, a methanol extract of PP markedly reduced the degree of inflammatory cell recruitment, including inflammatory cytokines and chemokines, which are considered important indicators of the progression of airway inflammatory in chronic obstructive pulmonary disease (COPD)-like models in animals (18). Therefore, the results from previous studies suggest the possibility that treatment with PP may effectively attenuate the inflammatory response in the lung tissues of allergic asthma animal models.…”

Novel benzofuran derivative DK-1014 attenuates lung inflammation via blocking of MAPK/AP-1 and AKT/mTOR signaling in vitro and in vivo

“…Pulmonary inflammation is characterized by elevated serum IgE and cytokine levels, airway hyper-responsiveness (AHR), airway eosinophilia, and mucus accumulation 2,3 . These inflammatory mediators, including proinflammatory cytokines and monocyte chemoattractant protein-1 (MCP-1), are produced by macrophages and airway epithelial cells via a series of inducible genes, leading to the infiltration of inflammatory cells into airway inflammation 4 . In addition, inflammatory cells produce nitric oxide (NO) or inflammatory cytokines and chemokines, which can be useful markers for airway inflammation 5,6 .…”