Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-κB activation

Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages

“…30) Previous studies have shown that several natural products potently suppress NO and TNFa production in macrophages by inhibiting NF-kB activation induced by an LPS signal. 31,32) The amounts of MC which have been used in this study are high concentrations, raising the possibility that the active agent or agents in the MC represent a small component of the total mass. Therefore, further investigation is necessary to clarify unknown constituents which may be more active than MC itself.…”

Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages

“…However, emodin has been reported to inhibit the NF-B gene expression in macrophages. 33,34) Aloe-emodin has also been shown to block the activation of IRF-1, but not NF-B in cancer cells. 35) We have shown that aloin, a glycoside, did not affect COX-2 or iNOS mRNA expression nor PGE 2 production.…”

Reduced Lipopolysaccharide (LPS)-Induced Nitric Oxide Production in Peritoneal Macrophages and Inhibited LPS-Induced Lethal Shock in Mice by a Sugar Cane (Saccharum officinarumL.) Extract

“…There are many reports of natural components having protective effects against endotoxin shock. [21][22][23] The protective effects of almost all of these products are considered to be due to modulating TNF-overproduction. [24][25][26] Interestingly, this present study has shown that LPS-induced TNF-production by mouse peritoneal macrophages cultured with LPS was not affected by the addition of SCE, consistent with the previous study that demonstrated no inhibitory effect of SCE on LPSinduced TNF-production.…”