Orthobunyavirus Antibodies in Humans, Yucatan Peninsula, Mexico

Blitvich, Bradley J.; Saiyasombat, Rungrat; Talavera-Aguilar, Lourdes G.; Garcia-Rejon, Julián E.; Farfán-Ale, José A.; Machaín-Williams, Carlos; Loroño-Pino, María Alba

doi:10.3201/eid1810.120492

Cited by 15 publications

(16 citation statements)

References 10 publications

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“…Human infections with the Cache Valley virus appear to be quite common in areas where the virus is enzootic and seroprevalence rates in humans may be as high as 18% (28). Although human neuroinvasive illness has rarely been diagnosed, there have been three reports of severe Cache Valleyviral associated disease in the United States including a fatal case of encephalitis (18,19).…”

Section: Clinical Casesmentioning

confidence: 99%

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Emerging mosquito-borne bunyaviruses in Canada

Drebot¹

2015

CCDR

103

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Section: Clinical Casesmentioning

confidence: 99%

“…Similar to the Jamestown Canyon virus, its main animal reservoir / amplifying host is believed to be deer (15,16). The Cache Valley virus was first isolated in 1956 in Cache Valley, Utah, USA but is endemic throughout Canada, the United States, the Caribbean, Mexico and Argentina (15,28,29). …”

Section: Cache Valley Virusmentioning

confidence: 99%

Emerging mosquito-borne bunyaviruses in Canada

Drebot¹

2015

CCDR

103

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“…[1][2][3][4] Humans are frequently exposed to the virus in endemic regions with antibody prevalence ranging from 3% to 19%. 2,[5][6][7] The development of severe disease occurs rarely in humans but is potentially life-threatening with symptoms ranging from fever to encephalitis. [8][9][10] In addition, CVV is responsible for epizootics in sheep, causing fetal death and congenital defects in these animals.…”

Section: Introductionmentioning

confidence: 99%

Emergence of a New Lineage of Cache Valley Virus (Bunyaviridae: Orthobunyavirus) in the Northeastern United States

Armstrong¹,

Andreadis²,

Anderson³

2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Cache Valley virus (CVV; Family Bunyavidae, Genus Orthobunyavirus) is a mosquito-borne zoonosis that frequently infects humans and livestock in North and Central America. In the northeastern United States, CVV transmission is unpredictable from year-to-year and may derive from the periodic extinction and reintroduction of new virus strains into this region. To evaluate this possibility, we sequenced and analyzed numerous CVV isolates sampled in Connecticut during an 18-year period to determine how the virus population may change over time. Phylogenetic analyses showed the establishment of a new viral lineage during 2010 that became dominant by 2014 and appears to have originated from southern Mexico. CVV strains from Connecticut also grouped into numerous sub-clades within each lineage that included viruses from other U.S. states and Canada. We did not observe the development and stable persistence of local viral clades in Connecticut, which may reflect the episodic pattern of CVV transmission. Together, our data support the emergence of a new lineage of CVV in the northeastern United States and suggest extensive dispersal of viral strains in North America.

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“…Subsequently, a case of aseptic meningitis due to CVV in an adult male from Wisconsin was reported (14). Other human infections with CVV have been inferred by serologic studies of CVV in areas of endemicity in the Delmarva Peninsula in the United States and in Yucatan, Mexico, with reported infection rates of up to 18% (15,16).…”

mentioning

confidence: 99%

Cache Valley Virus in a Patient Diagnosed with Aseptic Meningitis

et al. 2013

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f Cache Valley virus was initially isolated from mosquitoes and had been linked to central nervous system-associated diseases. A case of Cache Valley virus infection is described. The virus was cultured from a patient's cerebrospinal fluid and identified with real-time reverse transcription-PCR and sequencing, which also yielded the complete viral coding sequences. CASE REPORT In mid-September 2011, a 63-year-old woman presented to an upstate New York hospital with complaints of fever, headache, neck stiffness, and photophobia. One week earlier, she had noticed a macular, nonpruritic lesion on her right forearm, about 3 cm in diameter, with central clearing. Three days prior, as the first lesion was fading, a petechial rash developed on her lower extremities that spread to her torso. She then traveled to Pennsylvania for a weekend, and during this time she developed the mentioned fever and symptoms of meningitis. She returned home and went to the Emergency Department (ED) of the hospital the next morning.On physical examination, the patient appeared alert and oriented, with a blood pressure of 148-mm/80-mm Hg, a pulse rate of 87 per min, a respiratory rate of 18 per min, an oral temperature of 37.6°C, and an oxygen saturation of 99% on room air. She had a scattered, bilateral, petechial rash on her thighs; meanwhile, the lesions on her back and abdomen were fading. She had moderate neck stiffness. Her neurologic exam was otherwise normal; there was no evidence of encephalitis, cranial nerve abnormalities, or focal findings.Her medical record included a history of hypertension, hypothyroidism, meningioma, and migraine headaches and of rheumatic fever during childhood. The patient stated that she and her husband frequently camped outdoors. Throughout mid-to late August they camped in Wyoming and Livingston counties in New York state and also embarked on a 5-day camping trip in Dansville, NY, through Vermont and New Hampshire. She lived with her husband, had a cat, and frequently tended to her garden around her home. She had no knowledge of any sick contact.Her white blood cell count on presentation was 5,700/l, with a normal differential. Hematocrit was normal at 42%, and platelets were normal at 212,000/l. Computed tomography of the head without contrast showed mild atrophy without evidence of acute intracranial abnormality. Blood cultures were drawn, and she was sent home on doxycycline. The patient returned to the ED the following day with new complaints of nausea and vomiting in addition to the previously reported symptoms.The patient was admitted to the hospital with a preliminary diagnosis of aseptic meningitis. A lumbar puncture was performed, and the cerebrospinal fluid (CSF) showed 216 nucleated cells, with 91% lymphocytes, 7% monocytes, 1% basophils, and 1% polymorphonuclear cells. CSF chemistries were normal, with a glucose concentration of 60 mg/dl (56% of the serum level) and protein of 46 mg/dl. No microorganism was seen in the CSF by Gram stain. Magnetic resonance imaging of the brain showed only a ...

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Orthobunyavirus Antibodies in Humans, Yucatan Peninsula, Mexico

Cited by 15 publications

References 10 publications

Emerging mosquito-borne bunyaviruses in Canada

Emerging mosquito-borne bunyaviruses in Canada

Emergence of a New Lineage of Cache Valley Virus (Bunyaviridae: Orthobunyavirus) in the Northeastern United States

Cache Valley Virus in a Patient Diagnosed with Aseptic Meningitis

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