orthodenticleIs Required for Photoreceptor Cell Development in theDrosophilaEye

Vandendries, Erik; Johnson, Denise; Reinke, Rosemary

doi:10.1006/dbio.1996.0020

Cited by 104 publications

(119 citation statements)

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“…First, the rhabdomere defects observed otd uvi and Pph13 hazy mutants are similar (Vandendries et al, 1996). In each case, the defects appear not to be the result of degeneration but a failure in their biogenesis.…”

Section: Pph13 Is Only Required For Photoreceptor Terminal Differentimentioning

confidence: 90%

“…Previous reports have established or implicated eyeless (Pax6), orthodenticle (otd) and Onecut homeodomain genes in eye development (Nguyen et al, 2000;Quiring et al, 1994;Vandendries et al, 1996). What is the relationship between these various homeodomain transcription factors and how do they coordinate photoreceptor terminal differentiation?…”

Section: Pph13 Is Only Required For Photoreceptor Terminal Differentimentioning

confidence: 99%

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Mutation of the photoreceptor specific homeodomain genePph13results in defects in phototransduction and rhabdomere morphogenesis

et al. 2003

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The expression and organization of the phototransduction signaling proteins into a specialized light-sensing organelle, the rhabdomere, is required for photoreceptor cells to detect light. We report the characterization of the mutant Pph13 hazy . Pph13 is a homeodomain transcription factor expressed only in photoreceptor cells. Pph13 expression correlates with the differentiation and not specification of photoreceptor cells. In agreement with its expression profile, we find Pph13 is required for both rhabdomere morphogenesis and for the proper detection of light. In addition, we demonstrate that Pph13 exerts its effect by the regulation of photoreceptor specific gene expression.

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Section: Pph13 Is Only Required For Photoreceptor Terminal Differentimentioning

confidence: 90%

Section: Pph13 Is Only Required For Photoreceptor Terminal Differentimentioning

confidence: 99%

Mutation of the photoreceptor specific homeodomain genePph13results in defects in phototransduction and rhabdomere morphogenesis

et al. 2003

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“…Subsequent studies showed that Otd plays an essential role in Drosophila photoreceptor development (Vandendries et al, 1996) by regulating the expression of opsin genes (Tahayato et al, 2003). Mammals have three Otd orthologs, Otx1, Otx2 and Crx, which is equivalent to Otx5 in fish, amphibians and chick (Plouhinec et al, 2003).…”

Section: Factors Specifying the Photoreceptor Lineage -Otx2 And Crxmentioning

confidence: 99%

Regulation of photoreceptor gene expression by Crx-associated transcription factor network

2008

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Rod and cone photoreceptors in the mammalian retina are special types of neurons that are responsible for phototransduction, the first step of vision. Development and maintenance of photoreceptors require precisely regulated gene expression. This regulation is mediated by a network of photoreceptor transcription factors centered on Crx, an Otx-like homeodomain transcription factor. The cell type (subtype) specificity of this network is governed by factors that are preferentially expressed by rods or cones or both, including the rod-determining factors neural retina leucine zipper protein (Nrl) and the orphan nuclear receptor Nr2e3; and cone-determining factors, mostly nuclear receptor family members. The best-documented of these include thyroid hormone receptor β2 (Trβ2), retinoid related orphan receptor Rorβ, and retinoid X receptor Rxrγ. The appropriate function of this network also depends on general transcription factors and co-factors that are ubiquitously expressed, such as the Sp zinc finger transcription factors and STAGA coactivator complexes. These cell type-specific and general transcription regulators form complex interactomes; mutations that interfere with any of the interactions can cause photoreceptor development defects or degeneration. In this manuscript, we review recent progress on the roles of various photoreceptor transcription factors and interactions in photoreceptor subtype development. We also provide evidence of auto-, para-, and feedback regulation among these factors at the transcriptional level. These protein-protein and protein-promoter interactions provide precision and specificity in controlling photoreceptor subtype-specific gene expression, development and survival. Understanding these interactions may provide insights to more effective therapeutic interventions for photoreceptor diseases.

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“…Otd expression begins at the end of PR recruitment and is expressed in all PRs throughout development (Vandendries et al, 1996). (E-G) Larval (E), 50% pupal (F) and adult (G) eye co-staining with Otd (purple) and Sens (green).…”

Section: Research Articlementioning

confidence: 99%

Senseless functions as a molecular switch for color photoreceptor differentiation inDrosophila

et al. 2007

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A major question in development is how different specialized cell types arise from a common progenitor. In the adult Drosophila compound eye, color discrimination is achieved by UV-, blue-and green-sensitive photoreceptors (PRs). These different PR subsets arise from neuronal precursors called R7 and R8 cells. Recent studies have demonstrated that R7-based UV-sensitive PRs require the repression of R8-based blue/green-sensitive PR characteristics to properly develop. This repression is mediated by the transcription factor Prospero (Pros). Here, we report that Senseless (Sens), a Drosophila ortholog of the vertebrate Gfi1 transcription factor, plays an opposing role to Pros by both negatively regulating R7-based features and positively enforcing R8-based features during terminal differentiation. In addition, we demonstrate that Pros and Sens function together with the transcription factor Orthodenticle (Otd) to oppositely regulate R7 and R8 PR Rhodopsin gene expression in vitro. These data show that sens, previously shown to be essential for neuronal specification, also controls differentiation of specific neuronal subtypes in the retina. Interestingly, Pros has recently been shown to function as a tumor suppressor, whereas Gfi1 is a well-characterized oncogene. Thus, we propose that sens/pros antagonism is important for regulating many biological processes.

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orthodenticleIs Required for Photoreceptor Cell Development in theDrosophilaEye

Cited by 104 publications

References 0 publications

Mutation of the photoreceptor specific homeodomain genePph13results in defects in phototransduction and rhabdomere morphogenesis

Mutation of the photoreceptor specific homeodomain genePph13results in defects in phototransduction and rhabdomere morphogenesis

Regulation of photoreceptor gene expression by Crx-associated transcription factor network

Senseless functions as a molecular switch for color photoreceptor differentiation inDrosophila

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