Orthogonal experimental design of titanium dioxide—Poly(methyl methacrylate) electrospun nanocomposite membranes for photocatalytic applications

Vild, Andrew; Teixeira, Sara; Kühn, Klaus; Cuniberti, Gianaurelio; Sencadas, Vítor

doi:10.1016/j.jece.2016.06.029

Cited by 42 publications

(20 citation statements)

References 30 publications

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“…The scores of the nine composite membranes were calculated according to the proportions. All performance scores were added to get the total score; according to the factors, the total scores were averaged to obtain K. According to the factors, the scores of a certain performance were added and arranged in sequence, and the degree of the influence of the factors on the performance can be judged [31]. Because the composite film is intended for food packaging applications, it is required to have high strength and ductility.…”

Section: Results Of Orthogonal Experimentsmentioning

confidence: 99%

“…Moreover, since food packaging often comes into contact with water and oils, the lower the water absorption, oil permeability coefficient, and moisture permeability coefficient, the better the composite film. In addition, the film should have high light transmittance so that the packaging contents can be clearly visible [31,32]. Table 3 shows the results of the orthogonal experimental design.…”

Section: Results Of Orthogonal Experimentsmentioning

confidence: 99%

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Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

2018

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A sodium alginate/chitosan solution was prepared by dissolving sodium alginate, chitosan, and glycerol in an acetic acid solution. This solution was then combined with a sodium carboxymethyl cellulose solution and the mixture was cast onto a glass plate and dried at a constant temperature of 60 • C. Then, a carboxymethyl cellulose/sodium alginate/chitosan composite film was obtained by immersing the film in a solution of a cross-linking agent, CaCl 2 , and air-drying the resulting material. First, the most advantageous contents of the three precursors in the casting solution were determined by a completely random design test method. Thereafter, a comprehensive orthogonal experimental design was applied to select the optimal mass ratio of the three precursors. The composite film obtained with sodium alginate, sodium carboxymethyl cellulose, and chitosan contents of 1.5%, 0.5%, and 1.5%, respectively, in the casting solution displayed excellent tensile strength, water vapor transmission rate, and elongation after fracture. Moreover, the presence of chitosan successfully inhibited the growth and reproduction of microorganisms. The composite film exhibited antibacterial rates of 95.7% ± 5.4% and 93.4% ± 4.7% against Escherichia coli and Staphylococcus aureus, respectively. Therefore, the composite film is promising for antibacterial food packaging applications.

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Section: Results Of Orthogonal Experimentsmentioning

confidence: 99%

Section: Results Of Orthogonal Experimentsmentioning

confidence: 99%

Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

2018

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“…In this sense, the expensive and time‐consuming step for photocatalysts recovery becomes unnecessary . Several substrates, such as glass, stainless steel, polymers, zeolites, silica and magnetic particles, among others, have been used in the immobilization of photocatalytic materials.…”

Section: Introductionmentioning

confidence: 99%

Reusable Photocatalytic Optical Fibers for Underground, Deep‐Sea, and Turbid Water Remediation

et al. 2018

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An approach for underground, deep, and turbid water remediation is presented based on optical fibers with a photocatalytic coating. Thus, photocatalytic TiO 2 P25 nanoparticles immobilized in a poly(vinylidene difluoride) (PVDF) matrix are coated on polymeric optical fibers (POFs) and the photocatalytic performance of the system is assessed under artificial sunlight. To the best of our knowledge, poly(methyl methacrylate)‐POF coated with TiO 2 /PVDF and the reusability of any type of POF for photocatalytic applications are not previously reported. The photocatalytic efficiency of the hybrid material in the degradation of ciprofloxacin (CIP) and its reusability are evaluated here. It is shown that 50 w/w% of TiO 2 P25 achieves a degradation of 95% after 72 h under artificial sunlight and a reusability of three times leads to a loss of activity inferior to 11%. The efficient removal of ciprofloxacin and the stability of the POF coated with TiO 2 P25 successfully demonstrate its suitability in the degradation of pollutants with potential application in regions with low light illumination, as in underground and deep water.

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“…where and represents the mean and range values, respectively, for a factor at the level [28,29]. The impact of the three factors (gel concentration, feed rate and inlet temperature) on the average particle diameter was evaluated by investigating the influence of different levels of each factor [28].…”

Section: A C C E P T E Dmentioning

confidence: 99%

“…Results of average particle diameter, coefficient of variation and orthogonal indexes are presented in table 2, for the experimental runs from A to I (table 1). The larger the parameter, the more influence of the factor on the process, reflecting either valuable or detrimental effects [28,29,35,36]. For the processing of gel microparticles by spray-drying, gelatin concentration is the most important factor followed by the feed rate and the inlet temperature ( > > ).…”

Section: Optimization Of Gelatin Microparticlesmentioning

confidence: 99%

Development and optimization of ciprofloxacin-loaded gelatin microparticles by single-step spray-drying technique

et al. 2018

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Polymeric particles are a versatile class of local or systemic drug delivery systems, used to improve drugs pharmacokinetics and pharmacodynamics along with patient compliance. Herein, we report a rapid, scalable, and optimized method to encapsulate ciprofloxacin (CP x ), a poor water soluble antimicrobial agent, in gelatin microparticles by single step processing via spray-drying of an aqueous solution. The developed particles show mainly a wrinkle morphology with a unimodal distribution, with mean diameters ranging between 2 and 4 μm, depending on the processing conditions. The encapsulation of 1, 2 and 5 wt% CPx narrows the size distribution (1-3 μm). In vitro release experiments showed that up to 80% of encapsulated drug is released during the first 6 h, and the release kinetics was best fitted with the Korsmeyer-Peppas model, explained by the superimposition of drug diffusion and polymer chain relaxation. The minimal inhibitory concentrations against S. aureus and E. coli, obtained from pure and encapsulated ciprofloxacin, demonstrated that the spray-drying process does not inhibit the drug's bioactivity or the process feasibility. Thus, spray-drying of protein-drug particle systems is an advantageous method to produce microparticles with potential to lung delivery systems. Smith, M. L. & Sencadas, V. (2018). Development and optimization of ciprofloxacin-loaded gelatin microparticles by single-step spray-drying technique. Powder Technology, 330 201-209. Abstract:Polymeric particles are a versatile class of local or systemic drug delivery systems, used to improve drugs pharmacokinetics and pharmacodynamics along with patient compliance. Herein, we report a rapid, scalable, and optimized method to encapsulate ciprofloxacin (CPx), a poor water soluble antimicrobial agent, in gelatin microparticles by single step processing via spray-drying of an aqueous solution. The developed particles show mainly a wrinkle morphology with a unimodal distribution, with mean diameters ranging between 2 and 4 , depending on the processing conditions. The encapsulation of 1, 2 and 5 wt% CPx narrows the size distribution (1-3 m). In vitro release experiments showed that up to 80% of encapsulated drug is released during the first 6 hours, and the release kinetics was best fitted with the Korsmeyer-Peppas model, explained by the superimposition of drug diffusion and polymer chain relaxation. The minimal inhibitory concentrations against S. aureus and E. coli, obtained from pure and encapsulated ciprofloxacin, demonstrated that the spraydrying process does not inhibit the drug`s bioactivity or the process feasibility. Thus, spray-drying of protein-drug particle systems is an advantageous method to produce microparticles with potential to lung delivery systems.

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Orthogonal experimental design of titanium dioxide—Poly(methyl methacrylate) electrospun nanocomposite membranes for photocatalytic applications

Cited by 42 publications

References 30 publications

Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

Reusable Photocatalytic Optical Fibers for Underground, Deep‐Sea, and Turbid Water Remediation

Development and optimization of ciprofloxacin-loaded gelatin microparticles by single-step spray-drying technique

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