Orthogonally combined motion‐ and diffusion‐sensitized driven equilibrium (OC‐MDSDE) preparation for vessel signal suppression in 3D turbo spin echo imaging of peripheral nerves in the extremities

Cervantes, Barbara; Kirschke, Jan S.; Klupp, Elizabeth; Kooijman, Hendrik; Börnert, Peter; Haase, Axel; Rummeny, Ernst J.; Karampinos, Dimitrios C.

doi:10.1002/mrm.26660

Cited by 16 publications

(9 citation statements)

References 36 publications

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“…This can be the result of magnetic field inhomogeneity at air–tissue interfaces. Methods to possibly limit B 0 and B 1 inhomogeneity include using adiabatic refocusing pulses 21 or double refocusing pulses 21,30 …”

Section: Discussionmentioning

confidence: 99%

Near‐Silent and Distortion‐Free Diffusion MRI in Pediatric Musculoskeletal Disorders: Comparison With Echo Planar Imaging Diffusion

Sandberg

Young

Syed

et al. 2020

Magnetic Resonance Imaging

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BackgroundDiffusion‐weighted imaging (DWI) is common for evaluating pediatric musculoskeletal lesions, but suffers from geometric distortion and intense acoustic noise.PurposeTo investigate the performance of a near‐silent and distortion‐free DWI sequence (DW‐SD) relative to standard echo‐planar DWI (DW‐EPI) in pediatric extremity MRI.Study TypeProspective validation study.SubjectsThirty‐nine children referred for extremity MRI.Field Strength/SequenceDW‐EPI and DW‐SD, based on a rotating ultrafast sequence modified with sinusoidal diffusion preparation gradients, at 3T.AssessmentDW‐SD image quality (Sanat) was assessed from 0 (nondiagnostic) to 5 (outstanding) and comparative image quality (Scomp) (from –2 = DW‐EPI more delineated to +2 = DW‐SD more delineated, 0 = same). ADC measured by DW‐SD and DW‐EPI were compared in bone marrow, muscle, and lesions.Statistical TestsWilcoxon rank‐sum test and confidence interval of proportions (CIOP) were calculated for Scomp, Student's t‐test, coefficient of variation (COV), and Bland–Altman analysis for ADC values, and intraclass correlation coefficient (ICC) for interreader agreement.ResultsDW‐SD and DW‐EPI ADC values for bone marrow, muscle, and lesions were not significantly different (P = 0.3, P = 0.2, and P = 0.27, respectively) and had an overall ADC COV of 14.8% (95% confidence interval: 12.3%, 16.9%) and no significant proportional bias on Bland–Altman analysis. Sanat CIOP was rated diagnostic or better (score of 3, 4, or 5) in 72–98% of cases for bone marrow, muscle, and soft tissues. DW‐SD was equivalent to or preferred over DW‐EPI in muscles and soft tissues, with CIOP 86–93% and 93%, respectively. Lesions were equally visualized on DW‐SD and DW‐EPI in 40–51%, with DW‐SD preferred in 44–56% of cases. DW‐SD was rated significantly better than DW‐EPI across all comparative variables that included bone marrow, muscle, soft tissue, cartilage, and lesions (P < 0.05). Readers had moderate to near‐perfect (ICC range = 0.45–0.85).Data ConclusionDW‐SD of the extremities provided similar ADC values and improved image quality compared with conventional DW‐EPI.Level of Evidence 2Technical Efficacy Stage 2J. MAGN. RESON. IMAGING 2021;53:504–513.

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Section: Discussionmentioning

confidence: 99%

Near‐Silent and Distortion‐Free Diffusion MRI in Pediatric Musculoskeletal Disorders: Comparison With Echo Planar Imaging Diffusion

Sandberg

Young

Syed

et al. 2020

Magnetic Resonance Imaging

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“…This may be due to the field inhomogeneity near the tissue boundaries. Future work should explore using adiabatic refocusing pulses or double refocusing pulses to improve the robustness to B 0 and B 1 inhomogeneity.…”

Section: Discussionmentioning

confidence: 99%

Near‐silent distortionless DWI using magnetization‐prepared RUFIS

Yuan

Menini³

et al. 2019

Magnetic Resonance in Med

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Purpose To develop a near‐silent and distortionless DWI (sd‐DWI) sequence using magnetization‐prepared rotating ultrafast imaging sequence. Methods A rotating ultrafast imaging sequence was modified with driven‐equilibrium diffusion preparation, including eddy‐current compensation methods. To compensate for the T1 recovery during readout, a phase‐cycling method was used. Both compensation methods were validated in phantoms. The optimized sequence was compared with an EPI diffusion sequence for image distortion, contrast, ADC, and acoustic noise level in phantoms. The sequence was evaluated in 1 brain volunteer, 5 prostate volunteers, and 10 pediatric patients with joint diseases. Results Combination of several eddy‐current compensation methods reduced the artifact to an acceptable level. Phase cycling reduced T1 recovery contamination during readout. In phantom scans, the optimized sequence generated similar image contrast to the EPI diffusion sequence, and ADC maps between the sequences were comparable; sd‐DWI had significantly lower acoustic noise (P < .05). In vivo brain scan showed reduced image distortion in sd‐DWI compared with the EPI diffusion, although residual motion artifact remains due to brain pulsation. The prostate scans showed that sd‐DWI can provide similar ADC compared with EPI diffusion, with no image distortion. Patient scans showed that the sequence can clearly depict joint lesions. Conclusion An sd‐DWI sequence was developed and optimized. Compared with conventional EPI diffusion, sd‐DWI provided similar diffusion contrast, accurate ADC measurement, improved image quality, and minimal ambient scanning noise. The sequence showed the ability to obtain in vivo diffusion contrast in relatively motion‐free body regions, such as prostate and joint.

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“…Finally, the present T2 preparation did not use flow or diffusion encoding gradients, thus giving rise to potential signal contamination by surrounding CSF and vessels. The T2 preparation modules with flow or diffusion encoding gradients could be used in the future to remove CSF and vessel signal contamination [5,7,21].…”

Section: Discussionmentioning

confidence: 99%

High Isotropic Resolution T2 Mapping of the Lumbosacral Plexus with T2-Prepared 3D Turbo Spin Echo

et al. 2018

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Purpose Isotropic high-resolution three-dimensional (3D) magnetic resonance neurography (MRN) is increasingly used to depict even small and highly oblique nerves of the lumbosacral plexus (LSP). The present study introduces a T2 mapping sequence (T2-prepared 3D turbo spin echo) that is B1-insensitive and enables quantitative assessment of LSP nerves. Methods In this study 15 healthy subjects (mean age 28.5 ± 3.8 years) underwent 3 T MRN of the LSP area three times. The T2 values were calculated offline on a voxel-by-voxel basis and measured at three segments (preganglionic, ganglionic, postganglionic) of three LSP nerves (S1, L5, L4) by two independent investigators (experienced and novice). Normative data for the different nerves were extracted and intraclass correlation coefficients (ICCs) were calculated to assess reproducibility and interobserver reliability of T2 measurements. Results The T2 mapping showed excellent reproducibility with ICCs ranging between 0.99 (S1 preganglionic) and 0.89 (L5 postganglionic). Interobserver reliability was less robust with ICCs ranging between 0.78 (S1 preganglionic) and 0.44 (L5 postganglionic) for S1 and L5. A mean T2 value of 74.6 ± 4.7 ms was registered for preganglionic segments, 84.7 ± 4.1 ms for ganglionic and 65.4 ± 2.5 ms for postganglionic segments, respectively. There was a statistically significant variation of T2 values across the nerve (preganglionic vs ganglionic vs postganglionic) for S1, L5, and L4. Conclusion Our approach enables isotropic high-resolution and B1-insensitive T2 mapping of LSP nerves with excellent reproducibility. It might reflect a robust and clinically useful method for future diagnostics of LSP pathologies.

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Orthogonally combined motion‐ and diffusion‐sensitized driven equilibrium (OC‐MDSDE) preparation for vessel signal suppression in 3D turbo spin echo imaging of peripheral nerves in the extremities

Cited by 16 publications

References 36 publications

Near‐Silent and Distortion‐Free Diffusion MRI in Pediatric Musculoskeletal Disorders: Comparison With Echo Planar Imaging Diffusion

Near‐Silent and Distortion‐Free Diffusion MRI in Pediatric Musculoskeletal Disorders: Comparison With Echo Planar Imaging Diffusion

Near‐silent distortionless DWI using magnetization‐prepared RUFIS

High Isotropic Resolution T2 Mapping of the Lumbosacral Plexus with T2-Prepared 3D Turbo Spin Echo

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