Orthogonally Dual-Clickable Janus Nanoparticles via a Cyclic Templating Strategy

Abstract

Synthetic asymmetrical systems, Janus particles and patchy particles, are capable of undergoing hierarchical assembly processes that mimic those of Nature, to serve as switchable devices, optical probes, phase-transfer catalysts and multi-functional drug carriers, each of which benefits from opposing surface patterns behaving differently. Production of nanometer-sized Janus particles that are equipped with efficient chemistries remains a challenge. A robust Janus-faced polymer nanoparticle framework that presents two orthogonally click-reactive surface chemistries, has been generated by a recyclable strategy that involves reactive functional group transfer by templating against gold nanoparticle substrates. This anisotropic functionalization approach is compatible with a wide range of soft materials, providing Janus nanoparticles for the construction of dual-functionalized devices by accurately controlling chemical functionality at the nanoscopic level.

Facile Synthesis of Clickable, Water-Soluble, and Degradable Polyphosphoesters

“…36 GPC traces of the PEGylated copolymer 7 and its precursor 6 (Fig. 4) demonstrated that the grafting of PEG in water was successful.…”

Metallic Janus and Patchy Particles

“…Copyright 2012, Royal Society of Chemistry. Panel (F) reproduced with permission 36. Copyright 2011, American Chemical Society.…”

“…Masking techniques involve the protection of one part of a preformed particle to selectively functionalize the exposed face. Protection can be carried out by adsorption over flat substrates35 or particles,36 by microcontact printing methods37 and with Pickering emulsions 19. As an example, Eriksson et al recently reported the electrochemical oxidation of thiolated non‐conductive magnetic beads 35.…”

Synthesis, Characterization, and Directional Binding of Anisotropic Biohybrid Microparticles for Multiplexed Biosensing

“…Furthermore, another bioconjugation reaction between maleimides and thiols is also efficient because the reaction can be performed under physiologically relevant solvents and form a stable covalent linkage . Therefore, consecutive bioconjugation reactions executed by a maleimide‐thiol coupling reaction and Huisgen 1,3‐dipolar cycloaddition could be employed to prepare anisotropic biohybrid microparticles (MPs) with two different biomolecules spatio‐selectively conjugated on each compartment for multiplexing biodetection applications …”