Orthogonally Functionalizable Polyurethane with Subsequent Modification with Heparin and Endothelium-Inducing Peptide Aiming for Vascular Reconstruction

Fang, Jun; Zhang, Jialing; Du, Jun; Pan, Yanjun; Shi, Jiyun; Peng, Yongxuan; Chen, Wei-Ming; Liu, Yuan; Ye, Sang‐Ho; Wagner, William R.; Yin, Meng; Mo, Xiumei

doi:10.1021/acsami.6b04289

Cited by 50 publications

(32 citation statements)

References 41 publications

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“…[4][5][6] In addition to its well known antithrombin (AT) activity, 7,8 heparin has been shown to promote endothelialization 9 and inhibit smooth muscle cell (SMC) proliferation. 10,11 Therefore, heparinization of a surface may be expected to endow it with these diverse and desirable properties.…”

Section: Introductionmentioning

confidence: 99%

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

Chen

et al. 2017

J. Mater. Chem. B

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Blood compatible materials are required for a wide variety of medical devices. Despite many years of intensive effort, however, the blood compatibility problem, in particular the ability to prevent thrombosis, remains unsolved. Based on the knowledge that the vascular endothelium, the ultimate blood contacting surface, draws on several mechanisms to maintain blood fluidity, it seems reasonable that analogous multifunctionality should be the goal for blood compatible biomaterials.In the present work, a polyurethane surface was modified with the terpolymer poly(2-hydroxyethyl methacrylate-co-6amino-2-(2-methacylamido)-hexanoic acid-co-1-adamantan-1-yl methyl methacrylate) (poly(HEMA-co-LysMA-co-AdaMA)), referred to as PU-PHLA. Poly(HEMA) and poly(LysMA) were intended to provide, respectively, resistance to non-specific protein adsorption and the ability to lyse incipient clots. The heparin-like moiety, sulfonated β-cyclodextrin was immobilized on the PU-PHLA via host-guest interactions with the poly(AdaMA). This component is expected to inhibit coagulation and smooth muscle cell proliferation and to promote endothelialization. The resulting materials were shown to have multifunctionalities including fibrinolytic activity, anticoagulant activity and the ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion. This work provides a new strategy for the development of multifunctional, endothelial-mimicking, biomaterials for blood contacting applications.

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Section: Introductionmentioning

confidence: 99%

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

Chen

et al. 2017

J. Mater. Chem. B

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“…A similar approach was followed later by Mayor, Wöll and co‐workers, who reported an ultrathin 2D‐woven fabric . Using the well‐established SURMOF epitaxial growth, a reactive cross‐linkable layer was embedded in a non‐reactive MOF.…”

Section: Multi‐scale Controls Of Polymers Using Mofsmentioning

confidence: 94%

Polymer in MOF Nanospace: from Controlled Chain Assembly to New Functional Materials

Ouay

Uemura

2018

Israel Journal of Chemistry

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Preparation of composites by inclusion of polymers inside metal-organic frameworks (MOFs) is a very powerful strategy to prepare innovative functional materials. MOF's nanosized pores disrupt polymer chains natural coiling and constrain them in an extended conformation, bringing new properties. At the single nanochannel scale, polymerization reactions are significantly modified due to confinement, and control over the primary structure (sequence, tacticity or branching) can be achieved. Because of confinement and chain extension, physical and chemical properties can also be significantly improved compared to the bulk state. Inclusion is also useful to control organization at a higher scale, for instance for precise polymer positioning or by acting as scaffold for an accessible microporous polymer network. Furthermore, the MOF ordering can be maintained in pure polymer systems even after removal of the host.

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“…Our GDYNR provides the first example to achieve interwoven structures by self‐assembly of nanoribbons, which is a fascinating reaction in polymer chemistry, that is, self‐assembly of nanotextiles consisting of interwoven one‐ dimensional fibers of monomolecular thickness by a bottom‐up approach . This strategy would pave a novel way to construct well‐defined materials by weaving their subcomponents, such as protective coating of the electrodes.…”

Section: Figurementioning

confidence: 99%

Controllable Synthesis of Graphdiyne Nanoribbons

et al. 2020

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Graphdiyne nanoribbons with high chemical precision are of great significance for further understanding of the intrinsic properties of graphdiyne and the relationship between structure and properties. However, the reliable synthesis of graphdiyne nanoribbons with chemical precision remains a significant challenge. A facile method is now presented for fabrication of graphdiyne nanoribbons with uniform width through stepwise inter‐ and intramolecular Glaser–Hay coupling reaction of ethynyl groups. The synthetic ribbons were interwoven into nanotextiles by π–π stacking and were applied for protective coating of Li‐electrode in Li‐ion batteries, which efficiently suppressed the growth of the Li dendrites during cycling and prolonged the life span of Li‐metal batteries.

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Orthogonally Functionalizable Polyurethane with Subsequent Modification with Heparin and Endothelium-Inducing Peptide Aiming for Vascular Reconstruction

Cited by 50 publications

References 41 publications

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

Polymer in MOF Nanospace: from Controlled Chain Assembly to New Functional Materials

Controllable Synthesis of Graphdiyne Nanoribbons

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