Orthotopic bone induction at sites of Moloney murine sarcoma virus inoculation in mice

Włodarski, K; Kobus, M; Łuczak, M.

doi:10.1038/281386a0

Cited by 14 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Periosteal bone induction is initiated by cells residing in the periosteal membrane, which are activated by growth factors that are released during immune-mediated spontaneous regression of the tumor MSV-induced [1,28], or by lesions elicited by the T cell mitogen Concanavalin A [29]. …”

Section: Discussionmentioning

confidence: 99%

“…Thus, the process of periosteal bone formation recapitulates both endochondral and intramembranous osteogenesis, the last type dominating. The newly formed bone collar is firmly attached to maternal bone and is very slowly resorbed by osteoclasts, so in some cases an increment of bone mass, sometimes exceeding 100% of the original mass, persists for several months post sarcoma development [1]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Time of Initial Exposure to MSV Sarcoma on Bone Induction by Dentine Matrix Implants and on Orthotopic Femora

Włodarski

Galus

et al. 2010

IJMS

View full text Add to dashboard Cite

HCl-demineralized murine lower incisors were implanted intramuscularly into syngeneic BALB/c mice to induce heterotopic osteogenesis. Implants were exposed at the early, preosteogenic stage (4), or at the later, osteogenic stage (12) to the Moloney sarcoma virus (MSV), which within 3–4 days results in a sarcoma. The yield of bone induction was determined by weight of dry bone mass following NaOH hydrolysis of soft tissues. To verify the effect of this sarcoma on orthotopic local femoral bone, the dry mass of the tumor-exposed femora was measured and compared with the weight of MSV-unexposed contralateral controls. MSV-sarcoma or cells involved with their spontaneous rejection have a stimulatory effect on the periosteal membrane of the tumor-adjacent femoral bones, increasing their dry mass on average by 18%. No stimulatory effect on heterotopic bone induction was observed when the MSV sarcoma grew during the early, preosteogenic stage (4 onward), but when the tooth matrix had been exposed to such tumor at the already bone-forming stage, (12 onward), the yield of bone induction was enhanced. Thus, it is postulated that lesions induced by MSV during the early, preosteogenic stage inhibit recruitment of osteoprogenitor cells or degrade Bone Morphogenetic Proteins (BMPs) released by matrix resorbing inflammatory cells, whereas when acting on already existing bone they have a stimulatory effect.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Time of Initial Exposure to MSV Sarcoma on Bone Induction by Dentine Matrix Implants and on Orthotopic Femora

Włodarski

Galus

et al. 2010

IJMS

View full text Add to dashboard Cite

show abstract

“…The Department, the largest among similar Departments in the remaining Polish Medical Schools, has also conferred the highest number of Doctor of Medicine degrees and Professor titles. The scientific interests of the Department have concentrated, among other subjects, on in vitro induction of osteogenesis by various tissues, Maloney sarcoma virus and factors stimulating secretion of cytokines (Wlodarski, 1969;Wlodarski et al, 1979), and on various aspects of structure and organisation of skeletal tissues (Ostrowski et al, 1991(Ostrowski et al, , 1993. The group headed by Professor Moskalewski studied histogenesis of cartilage in vivo and in vitro and showed that individual chondrocytes are able to reconstitute the cartilage when transplanted into a recipient (Moskalewski, 1965;Moskalewski and Kawiak, 1965;Moskalewski et al, 1975Moskalewski et al, ,1983.…”

Section: Warszawamentioning

confidence: 99%

History and status of embryology and developmental biology at Polish Medical Faculties and Schools

Bartel¹

2008

Int. J. Dev. Biol.

View full text Add to dashboard Cite

In Poland, medical embryology (both scientific research and teaching of the subject) has traditionally involved Chairs of Histology and Embryology rather than Obstetrics and Gynecology. Before World War II, the most buoyant centers for embryological research among the five universities at the time (in Warsaw, Krakow, Poznan, Lvov and Vilnius), were the Chairs of Embryology and Histology at Medical Faculties of the Jagiellonian University in Krakow and the University of Vilnius. After World War II, eleven Medical Academies (Universities of Medicine) came into being (Warsaw, Krakow, Poznan, Lodz, Gdansk, Bialystok, Bydgoszcz, Szczecin, Wroclaw, Katowice and Lublin). They conduct scientific research on normal development of the human embryo as well as teratology studies. In the XX century, eminent medicine-related embryologist included professors

show abstract

“…Some factors, such as certain viruses or transforming growth factor-~ promote orthtopic periosteal bone formation (12)(13)(14). Osteogenic reaction in these factors results exclusively in cell proliferation in the cambium layer of the periosteum.…”

Section: ( 152 )mentioning

confidence: 99%

Histological study of effect of bone morphogenetic protein derived from bovine tooth on periosteum in rats

et al. 1990

View full text Add to dashboard Cite

SUMMARYIn this study, we examined histologically the effect of a bone morphogenetic protein (BMP) derived from bovine tooth on the periosteum. Supraperiosteal injection of crude BMP into femurs of Wistar rats (28 day old) resulted in periosteal cell proliferation with subsequent bone and cartilage formation. Moreover, proliferating periosteal cells migrated into injected BMP, and formed both cartilage and bone. These observations show that exogenous BMP stimulates mesenchymal cells of the periosteum to proliferate and differentiate into osteoblasts, and therefore BMP may be one of factors which are involved in differentiation of osteoblasts in the periosteum. Bone Periosteum

show abstract

Orthotopic bone induction at sites of Moloney murine sarcoma virus inoculation in mice

Cited by 14 publications

References 7 publications

Effects of Time of Initial Exposure to MSV Sarcoma on Bone Induction by Dentine Matrix Implants and on Orthotopic Femora

Effects of Time of Initial Exposure to MSV Sarcoma on Bone Induction by Dentine Matrix Implants and on Orthotopic Femora

History and status of embryology and developmental biology at Polish Medical Faculties and Schools

Histological study of effect of bone morphogenetic protein derived from bovine tooth on periosteum in rats

Contact Info

Product

Resources

About