Orthotopic Transplantation of Tooth Buds Among Histoincompatible Mice

Gr, Riviere; Wh, Hildemann

doi:10.1097/00007890-197312000-00018

Cited by 9 publications

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“…This has been confirmed by Riviere et al (1971). Further work by Riviere & Hildemann (1973) has established that teeth apparently undergo repair once the reaction stimulated by multiple weak differences subsides.…”

Section: Immunogenetical Studies Of Transplanted Teethmentioning

confidence: 74%

Histopathological and immunological aspects of tooth transplantation

Atkinson

1978

J Oral Pathology Medicine

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Histopathological studies of teeth transplanted between genetically identical animals and to animals in which the immune response is suppressed or enhanced show that autografts and isografts degenerate but then are repaired, whereas allografts show a bewildering array of changes from almost total destruction to total repair. Some explanations for the repair of teeth in an immunologically hostile environment are put forward.The immunological aspects of tooth transplantation are also reviewed. Transplanted teeth stimulate an immune response from the host and are subject to the same rules of genetic relationship which apply to other tissues. Most components of the teeth are antigenic in isolation but only the pulp and periodontal ligament have so far been demonstrated to possess these properties //; vivo. Transplanted teeth also elicit antibody formation but the importance of antibodies in the rejection process is still disputed.It is concluded that teeth are not immunologically privileged tissues but will elicit cell mediated responses from allogeneic hosts and are subject to the same invasive destructive lesions as a result. The peculiar observations of repair of allogeneic teeth and delayed immune responses can be explained by considering the histopathology of transplanted teeth and their capacity for repair.Finally, the use of transplanted teeth to study odontogenesis and pathological entities such as odontogenic cysts and reparative dentin formation are briefly reviewed.

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Section: Immunogenetical Studies Of Transplanted Teethmentioning

confidence: 74%

Histopathological and immunological aspects of tooth transplantation

Atkinson

1978

J Oral Pathology Medicine

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“…First-set and second-set five-mm-diameter donor-strain skin grafts, obtained from the body wall, were transplanted as previously described. 10 First-set skin transplants were re-bandaged after seven days, and second-set skin transplants after five days. Each graft was observed daily until it was completely rejected.10 Median survival times (MST), their 95% confidence limits, and the significance of differences between MST values were calculated by the nomographic method of Litchfield.…”

Section: Methodsmentioning

confidence: 99%

Skin Graft Rejection After Allogeneic Tooth Transplants in Mice

Riviere

1984

J Dent Res

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Three strain combinations of in-bred mice representing strong and moderate histocompatibility barriers were used to determine if tooth allotransplants evoked strong or weak immunologic memory as measured by the second-set donor-strain skin graft technique. At issue was whether the anatomic site of engraftment could influence the outcome of these experiments. Recipients received either 5-mm-diameter skin grafts or one or four adult teeth. Experimental transplants were placed in subcutaneous pouches or in ear pouches. Control mice received only orthotopic skin grafts. Second-set orthotopic skin grafts were placed either one mo, six mo, or 11 mo after primary transplants. Skin grafts were observed daily until rejection occurred. We found that skin provoked strong memory in subcutaneous tissues, but that teeth generated very weak memory in subcutaneous tissues. Conversely, teeth placed in ear pouches were able to generate strong immunologic memory. This occurred whether donor and recipient shared H-2 allo-antigens, or whether one tooth or four teeth were grafted, and the difference persisted for at least six mo. We conclude that teeth are not weak antigens, nor is the subcutaneous site privileged regarding immunologic memory. Rather, there seems to be some critical interaction between teeth and the immune system draining subcutaneous tissues that results in a failure to generate strong anamnestic immunity. Perhaps definition of the processes involved will be of advantage in future human applications.

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continued development of 5-day old tooth-germs transplanted to syngeneic hamster (Mesocricetus auratus) cheek pouch

Al-Talabani

Smith

1978

Archives of Oral Biology

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Orthotopic Transplantation of Tooth Buds Among Histoincompatible Mice

Cited by 9 publications

References 0 publications

Histopathological and immunological aspects of tooth transplantation

Histopathological and immunological aspects of tooth transplantation

Skin Graft Rejection After Allogeneic Tooth Transplants in Mice

continued development of 5-day old tooth-germs transplanted to syngeneic hamster (Mesocricetus auratus) cheek pouch

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