continued development of 5-day old tooth-germs transplanted to syngeneic hamster (Mesocricetus auratus) cheek pouch

Al-Talabani, Nazar G.; Smith, Colin J.

doi:10.1016/0003-9969(78)90110-3

Cited by 9 publications

(2 citation statements)

References 19 publications

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“…The periodontium, consisting of cementum, periodontal ligament and alveolar bone, is not only a functional unit attaching the tooth to the jawbone, but also a developmental unit. This has been shown in a number of experiments in which teeth transplanted to various ectopic positions have developed periodontal ligament as well as alveolar bone (16–21). The results of the present studies are in agreement with those previous investigations.…”

Section: Discussionmentioning

confidence: 86%

Effects and distribution of the enamel matrix derivative Emdogain^® in the periodontal tissues of rat molars transplanted to the abdominal wall

Hamamoto

Kawasaki

Jarnbring

et al. 2002

Dental Traumatology

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The enamel matrix derivative Emdogain (EMD) has been found to promote regeneration of lost periodontal tissues. We have studied the effects and distribution of EMD in the periodontal tissues of maxillary rat molars transplanted to a subcutaneous position in the abdominal wall. The molars were transplanted with or without EMD either immediately after extraction or after drying for 30 min. After 2 days, 1, 2 or 4 weeks the rats were killed and the teeth were examined by means of light microscopy and immunohistochemistry with anti-amelogenin antibodies. Teeth transplanted immediately after extraction showed formation of alveolar bone separated from the dental roots by a periodontal space, regardless of the use of EMD. Among the teeth that were transplanted with EMD after drying for 30 min, new alveolar bone was formed in five out of eight teeth after 2 and 4 weeks. None of the teeth that were dried for 30 min and transplanted without EMD showed alveolar bone formation. Only one tooth transplanted with EMD showed root resorption after drying, while resorption was noted in all teeth transplanted without EMD. All teeth that were transplanted with EMD and none of the teeth that were transplanted without EMD showed an immunohistochemical reaction for amelogenin. After 2 days, amelogenin was precipitated on all surfaces exposed at the transplantation procedure. Later, the immunoreactive material was redistributed to cells at the root surface, where it was still demonstrable after 4 weeks. In conclusion, EMD is accumulated in cells at the root surface and promotes regeneration of the periodontal tissues of the transplanted teeth. It also seems to promote healing of root resorption.

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Section: Discussionmentioning

confidence: 86%

Effects and distribution of the enamel matrix derivative Emdogain^® in the periodontal tissues of rat molars transplanted to the abdominal wall

Hamamoto

Kawasaki

Jarnbring

et al. 2002

Dental Traumatology

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“…Many researchers have observed that alveolar bone formation occurs around bone graft materials as a result of experiments on animals [43][44][45][46][47]. Chung registered the patent for the technology of extracting proteins from teeth in 2002 and 2004; this carries an important, serving as evidence that teeth contain bone morphogenic protein [48,49].…”

Section: Osteoinduction Of Autobtmentioning

confidence: 99%

Healing Mechanism and Clinical Application of Autogenous Tooth Bone Graft Material

Kim¹,

Lee²,

Kim³

et al. 2013

Advances in Biomaterials Science and Biomedical Applications

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A histological study of the effect of developmental stage of tooth-germ on transplantation to hamster cheek pouch

Al-Talabani

Smith

1979

Archives of Oral Biology

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continued development of 5-day old tooth-germs transplanted to syngeneic hamster (Mesocricetus auratus) cheek pouch

Cited by 9 publications

References 19 publications

Effects and distribution of the enamel matrix derivative Emdogain^® in the periodontal tissues of rat molars transplanted to the abdominal wall

Effects and distribution of the enamel matrix derivative Emdogain^® in the periodontal tissues of rat molars transplanted to the abdominal wall

Healing Mechanism and Clinical Application of Autogenous Tooth Bone Graft Material

A histological study of the effect of developmental stage of tooth-germ on transplantation to hamster cheek pouch

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continued development of 5-day old tooth-germs transplanted to syngeneic hamster (Mesocricetus auratus) cheek pouch

Cited by 9 publications

References 19 publications

Effects and distribution of the enamel matrix derivative Emdogain® in the periodontal tissues of rat molars transplanted to the abdominal wall

Effects and distribution of the enamel matrix derivative Emdogain® in the periodontal tissues of rat molars transplanted to the abdominal wall

Healing Mechanism and Clinical Application of Autogenous Tooth Bone Graft Material

A histological study of the effect of developmental stage of tooth-germ on transplantation to hamster cheek pouch

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Effects and distribution of the enamel matrix derivative Emdogain^® in the periodontal tissues of rat molars transplanted to the abdominal wall

Effects and distribution of the enamel matrix derivative Emdogain^® in the periodontal tissues of rat molars transplanted to the abdominal wall