In this paper, we first consider difference equations with several delays in the neutral term of the form ⎛study various cases of coefficients in the neutral term and obtain the asymptotic behavior for non-oscillatory solution of ( * ) under some hypotheses. Moreover, we consider reaction-diffusion difference equations with several delays in the neutral term of the formr j u n−ρ j ,m ⎞ ⎠ + q n,m u n−τ,m = a 2 2 2 u n+1,m−1 for (n, m) ∈ Z + (0) × , study various cases of coefficients in the neutral term and obtain the asymptotic behavior for non-oscillatory solution under some hypotheses.