Oscillations in Cerebral Haemodynamics in Patients with Falciparum Malaria

Kolyva, Christina; Kingston, Hugh; Tachtsidis, Ilias; Mohanty, Sanjib; Mishra, Saroj K.; Patnaik, Rajya; Maude, Richard J.; Dondorp, Arjen M.; Elwell, Clare E.

doi:10.1007/978-1-4614-4989-8_15

Cited by 15 publications

(14 citation statements)

References 16 publications

(25 reference statements)

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“…Because of these modulation patterns, we are convinced that we measured physiological oscillations rather than non‐biological artefacts or systematic noise. In fact, different patterns of changing hemodynamic oscillations measured with NIRS have been widely reported by numerous studies from different groups in a vast population, including different species, healthy young and elderly populations, and patients with various pathological diseases (Obrig et al ., ; Schmidt‐Lucke et al ., ; Schroeter et al ., , ; Li et al ., , , ; Nasi et al ., ; van Beek et al ., ; Sassaroli et al ., ; Kolyva et al ., ; Cui et al ., ; Vermeij et al ., ). Our recent study showed that the cerebral hemodynamic oscillations in endothelial and neurogenic ranges measured with NIRS were enlarged by apnea events in patients with sleep apnea syndrome (SAS), and the increased oscillations induced by apnea events can be restored under positive airways pressure therapy (Zhang et al ., ).…”

Section: Discussionmentioning

confidence: 99%

“…Statistical analysis was performed on oscillations of HbO 2 , because spontaneous oscillations are most prominent in HbO 2 (Obrig et al ., ; Schroeter et al ., ; Li et al ., ; Kolyva et al ., ). In order to make valid comparisons of SDs and PSDs of different vasomotion components between different sleep stages, the SDs and PSDs of cerebral and muscular HbO 2 and SpO 2 were normalized to their mean values of the whole‐night measurements (Schroeter et al ., , ; Kolyva et al ., ). For example, normalization of the SDs of cerebral HbO 2 during LS was performed with the formula normalized‐SD LS = 3 × SD LS /(SD LS + SD SWS + SD REM ), where SD LS , SD SWS and SD REM were the SDs of cerebral HbO 2 during LS, SWS, and REM, respectively.…”

Section: Methodsmentioning

confidence: 97%

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Predominant endothelial vasomotor activity during human sleep: a near‐infrared spectroscopy study

Zhang

Khatami

2014

Eur J of Neuroscience

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Vasomotion is important in the study of vascular disorders, including stroke. Spontaneous low and very low hemodynamic oscillations (3-150 mHz) measured with near-infrared spectroscopy (NIRS) reflect the endothelial (3-20 mHz), neurogenic (20-40 mHz) and myogenic (40-150 mHz) components of vasomotion. We investigated sleep-specific patterns of vasomotion by characterizing hemodynamic oscillations with NIRS in healthy subjects, and tested the feasibility of NIRS as a bedside tool for monitoring vasomotion during whole-night sleep. To characterize local cerebral vasomotion, we compared cerebral NIRS measurements with muscular NIRS measurements and peripheral arterial oxygen saturation (SpO2 ) during different sleep stages in 14 healthy volunteers. Spectral powers of hemodynamic oscillations in the frequency range of endothelial vasomotion were systemically predominant in every sleep stage, and the powers of endothelial and neurogenic vasomotion decreased in deep sleep as compared with light sleep and rapid eye movement (REM) sleep in brain, muscle, and SpO2 . The decrease in the powers of myogenic vasomotion in deep sleep only occurred in brain, and not in muscle. These results point to a predominant role of endothelial function in regulating vasomotion during sleep. The decline in cerebral endothelial and neurogenic vasomotion during progression to deeper non-REM sleep suggests that deep sleep may play a protective role for vascular function. NIRS can be used to monitor endothelial control of vasomotion during nocturnal sleep, thus providing a promising non-invasive bedside tool with which to study the sleep-relevant pathological mechanisms in vascular diseases and stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 97%

Predominant endothelial vasomotor activity during human sleep: a near‐infrared spectroscopy study

Zhang

Khatami

2014

Eur J of Neuroscience

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“…These large oscillations, with amplitudes comparable to the hemodynamic response to sensory stimulus, are sporadic, but have been shown to occur in the rat (Golanov et al, 1994; Grosberg et al, 2012; Majeed et al, 2009; Mayhew et al, 1996; Saka et al, 2010), cat (Spitzer et al, 2001), awake rabbit (Hundley et al, 1988) and non-invasively in humans using near-infrared spectroscopy (Elwell et al, 1999; Kolyva et al, 2013; Näsi et al, 2011; Obrig et al, 2000; Sassaroli et al, 2012; Schroeter et al, 2005), and fMRI BOLD (Mitra et al, 1997). In some cases the appearance of SSHOs in the brain has been linked to distinct physiological conditions or states of arousal (Näsi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Direct, intraoperative observation of ~ 0.1 Hz hemodynamic oscillations in awake human cortex: Implications for fMRI

et al. 2014

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An almost sinusoidal, large amplitude ∼0.1 Hz oscillation in cortical hemodynamics has been repeatedly observed in species ranging from mice to humans. However, the occurrence of ‘slow sinusoidal hemodynamic oscillations’ (SSHOs) in human functional magnetic resonance imaging (fMRI) studies is rarely noted or considered. As a result, little investigation into the cause of SSHOs has been undertaken, and their potential to confound fMRI analysis, as well as their possible value as a functional biomarker has been largely overlooked. Here, we report direct observation of large-amplitude, sinusoidal ∼0.1 Hz hemodynamic oscillations in the cortex of an awake human undergoing surgical resection of a brain tumor. Intraoperative multispectral optical intrinsic signal imaging (MS-OISI) revealed that SSHOs were spatially localized to distinct regions of the cortex, exhibited wave-like propagation, and involved oscillations in the diameter of specific pial arterioles, confirming that the effect was not the result of systemic blood pressure oscillations. fMRI data collected from the same subject 4 days prior to surgery demonstrates that ∼0.1 Hz oscillations in the BOLD signal can be detected around the same region. Intraoperative optical imaging data from a patient undergoing epilepsy surgery, in whom sinusoidal oscillations were not observed, is shown for comparison. This direct observation of the ‘0.1 Hz wave’ in the awake human brain, using both intraoperative imaging and pre-operative fMRI, confirms that SSHOs occur in the human brain, and can be detected by fMRI. We discuss the possible physiological basis of this oscillation and its potential link to brain pathologies, highlighting its relevance to resting-state fMRI and its potential as a novel target for functional diagnosis and delineation of neurological disease.

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“…[28][29][30][31][32][33][34][35] The spontaneous low frequency oscillation (4-150 MHz) in these hemodynamic parameters further re°ects vasomotion in cerebral tissue. 16,[36][37][38] As a totally non-invasive and non-radioactive optical method, NIRS has sub-second temporal resolution and less motion restriction, 39,40 making it a powerful tool for all night sleep study. Although several studies with NIRS repeatedly reported an impairment of cerebral oxygenation in the patients with sleep apnea, [41][42][43][44][45] we still lack knowledge about the changes of cerebral autoregulation mechanism under CPAP therapy.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study

Zhang

Schneider

Fritschi

et al. 2014

J. Innov. Opt. Health Sci.

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In obstructive sleep apnea syndrome (OSA) the periodic reduction or cessation of breathing due to narrowing or occlusion of the upper airway during sleep leads to an impaired cerebral vascular autoregulation that is associated with an increased cardiovascular risk, including stroke. Continuous positive airways pressure (CPAP) therapy at night is the most e®ective treatment for OSA and has been shown to reduce the cardiovascular risk in OSA patients. However, there is no suitable bedside monitoring method evaluating the recovery of cerebral hemodynamics during CPAP therapy. Near-infrared spectroscopy (NIRS) is ideally suited for non-invasive monitoring the cerebral hemodynamics during sleep due to its properties of local measurement, totally safe application and good tolerance to motion. In this pilot study, we monitored cerebral hemodynamics during standard CPAP therapy at night in three patients with severe OSA using NIRS. We found periodic oscillations in HbO 2 , HHb, tissue oxygenation index (TOI) and blood volume (BV) associated with periodic apnea events without CPAP in all OSA patients. These oscillations were eliminated under the optimal CPAP pressures in all patients. These results suggested that the recovery of cerebral hemodynamics impaired by apnea events can be evaluated by bedside NIRS measurements in real time during all night CPAP therapy. NIRS is a useful bedside monitoring tool to evaluate the treatment e±cacy of CPAP therapy in patients with OSA.

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Oscillations in Cerebral Haemodynamics in Patients with Falciparum Malaria

Cited by 15 publications

References 16 publications

Predominant endothelial vasomotor activity during human sleep: a near‐infrared spectroscopy study

Predominant endothelial vasomotor activity during human sleep: a near‐infrared spectroscopy study

Direct, intraoperative observation of ~ 0.1 Hz hemodynamic oscillations in awake human cortex: Implications for fMRI

Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study

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