Osmotic capsules: A universal oral, controlled-release drug delivery dosage form

Waterman, Kenneth C.; Goeken, G. Scott; Konagurthu, Sanjay; Likar, M. D.; MacDonald, Bruce C.; Mahajan, Nidhi; Swaminathan, Vidya

doi:10.1016/j.jconrel.2011.02.001

Cited by 37 publications

(7 citation statements)

References 18 publications

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“…The use of a pH-sensitive hydrogel that will undergo swelling when transiting through the gastrointestinal tract from an acidic (gastric environment) to a mildly basic (small intestinal environment) condition has been a significant focal point for many researchers [1,2,3,4,5,6]. The small intestine is considered the most desirable location within the gastrointestinal tract for the delivery of gastric-sensitive bioactives [7,8,9,10,11,12]. However, traditional hydrogels are limited by the speed at which they can swell within a respective fluid, being a limiting factor for effective use of stimuli-responsive hydrogels for drug delivery applications [13].…”

Section: Introductionmentioning

confidence: 99%

Design of a Versatile pH-Responsive Hydrogel for Potential Oral Delivery of Gastric-Sensitive Bioactives

et al. 2017

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Abstract:A pH-responsive hydrogel system was prepared by free radical polymerization of acrylamide and methyl acrylic acid in the presence of N-N -methylene bisacrylamide. Sodium bicarbonate was further applied as a blowing agent, which afforded a porous hydrogel structure. The hydrogel system achieved a constant super swelling rate within simulated intestinal buffer (~4%/min) and remained relatively static within simulated gastric buffer (~0.8%/min). The hydrogel system was able to achieve matrix resilience greater than 30% under a relatively high strain of 40%. In addition, the hydrogel system demonstrated significant swelling properties in response to simulated intestinal environmental over 24 h, with contrasting characteristics in simulated gastric buffer. The hydrogel demonstrated type IV isotherm porosity characteristics, with remarkable MRI and SEM variations in gastric and intestinal simulated fluids. Drug loading was observed to be greater than 98% using theophylline as a prototype drug, evaluating its controlled release kinetics over 24 h. The hydrogel exhibited substantial pH-responsive activity, which could be used as a versatile platform for targeted release of gastric-sensitive therapeutics to the small intestine.

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Section: Introductionmentioning

confidence: 99%

Design of a Versatile pH-Responsive Hydrogel for Potential Oral Delivery of Gastric-Sensitive Bioactives

et al. 2017

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“…For example, simultaneously delivery of two or three drugs with different solubility was realized in a sandwiched osmotic pump tablet system, which consisted of a push layer and two attached drug layers on the opposite sides surrounded with a semi-membrane with two orifices on each side 11,12,13 . In another two examples, the co-delivery of metformin J U S T A C C E P T E D hydrochloride and glipizide were realized with a newly developed inlay osmotic pump tablet through including glipizide into HP-β-CD 14 and a modified push-pull osmotic system 15 , respectively.…”

Section: Introductionmentioning

confidence: 99%

Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology

Zhao¹,

Yu²,

Liu³

et al. 2016

Drug Development and Industrial Pharmacy

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The synchronous sustained-release of two drugs was desired urgently for patients needing combination therapy in long term. However, sophisticated technologies were used generally to realize the simultaneous delivery of two drugs especially those with different physico-chemical properties. The purpose of this study was to obtain the concurrent release of felodipine and metoprolol tartrate, two drugs with completely different solubilities, in a simple monolithic osmotic pump system (FMOP). Two types of blocking agents were used in monolithic osmotic pump tablets and the synchronous sustained-release of FMOP was acquired in vitro. The tablets were also administered to beagle dogs and the plasma levels of FMOP were determined by HPLC-MS/MS. The pharmacokinetic parameters were calculated using a non-compartmental model. Cmax of both felodipine and metoprolol from the osmotic pump tablets were lower, tmax and mean residence time of both felodipine and metoprolol from the osmotic pump tablets were longer significantly than those from immediate release tablets. These results verified prolonged release of felodipine and metoprolol tartrate from osmotic pump formulations. The similar absorption rate between felodipine and metoprolol in beagles was also obtained by this osmotic pump formulation. Therefore, it could be supposed that the accordant release of two drugs with completely different solubilities may be realized just by using monolithic osmotic pump technology.

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“…Asymmetric membrane capsules have been proven to be efficient gastroretentive systems carriers for osmotically regulated delivery of highly water-soluble drug, ranitidine hydrochloride, by a report published from our lab [ 4 ]. This concept is being extrapolated for a poorly water-soluble drug, acyclovir, based on the literature support of suitability of AMCs for delivery of poor water-soluble drug due to high water flux capability [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Cellulose Acetate 398-10 Asymmetric Membrane Capsules for Osmotically Regulated Delivery of Acyclovir

Sonkar

Kumar

Pathak

2016

Journal of Pharmaceutics

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The study was aimed at developing cellulose acetate asymmetric membrane capsules (AMCs) of acyclovir for its controlled delivery at the absorption site. The AMCs were prepared by phase inversion technique using wet process. A 23 full factorial design assessed the effect of independent variables (level(s) of polymer, pore former, and osmogen) on the cumulative drug release from AMCs. The buoyant optimized formulation F7 (low level of cellulose acetate; high levels of both glycerol and sodium lauryl sulphate) displayed maximum drug release of 97.88 ± 0.77% in 8 h that was independent of variation in agitational intensity and intentional defect on the cellulose acetate AMC. The in vitro data best fitted zero-order kinetics (r 2 = 0.9898). SEM micrograph of the transverse section confirmed the asymmetric nature of the cellulose acetate capsular membrane. Statistical analysis by Design Expert software indicated no interaction between the independent variables confirming the efficiency of the design in estimating the effects of variables on drug release. The optimized formulation F7 (desirability = 0.871) displayed sustenance of drug release over the drug packed in AMC in pure state proving the superiority of osmotically active formulation. Conclusively the AMCs have potential for controlled release of acyclovir at its absorption site.

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Osmotic capsules: A universal oral, controlled-release drug delivery dosage form

Cited by 37 publications

References 18 publications

Design of a Versatile pH-Responsive Hydrogel for Potential Oral Delivery of Gastric-Sensitive Bioactives

Design of a Versatile pH-Responsive Hydrogel for Potential Oral Delivery of Gastric-Sensitive Bioactives

Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology

Cellulose Acetate 398-10 Asymmetric Membrane Capsules for Osmotically Regulated Delivery of Acyclovir

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