Osmotically Controlled Drug Delivery System with Associated Drugs

Abstract

-Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain molecules may have low oral bioavailability because of solubility or permeability limitations. Development of an extended release dosage form also requires reasonable absorption throughout the gastro-intestinal tract (GIT). Among the available techniques to improve the bioavailability of these drugs fabrication of osmotic drug delivery system is the most appropriate one. Osmotic drug delivery systems release the drug with the zero order kinetics which does not depend on the initial concentration and the physiological factors of GIT. This review brings out new technologies, fabrication and recent clinical research in osmotic drug delivery. __________________________________________________________________________________________

Design and Pharmacodynamic Evaluation of Optimized Microporous Osmotic Tablets of Venlafaxine Hydrochloride

“…This causes ingress of water into the core compartment from the surrounding environment across the membrane and causes dissolution of the drug. This will subsequently lead to faster release of the drug [34] . Increase in concentration of pore former resulted in an obvious increase in number of pores and pore size, causing the drug to diffuse out easily.…”

“…These systems can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system is governed by various formulation factors such as the solubility and the osmotic pressure of the core components, nature of the rate controlling membrane [4] . Drugs can be delivered in a controlled pattern over a long period of time by the process of osmosis.…”

“Colon Targeted Delivery System (Codestm): Propitious Approach in Targeting Colon”

“…[5,6] Other applications for delivery of drug in colon include chronotherapy [7] , colon cancer prophylaxis and nicotine addiction treatment. [8,9] Many colon specific drug delivery systems (CSDDS) have been evaluated not only for treatment of colonic diseases, but also to enhance the bioavailability of drugs. Different approaches employing GI-transit time of different formulations, pH change, concentration of bacteria and GI-tract pressure have been documented to achieve CSDDS.…”

Diltiazem Hcl: Evaluation of Its Presence in Bangladesh

“…Locust bean gum (LB), also known as galactomanna, is obtained from the seed of Locust bean plant and is composed of a 1, 4-linked β-D mannan backbone with a 1, 6-linked α D-galactose side group. It is a non-ionic molecule consisting of 2000 residues; the ratio of mannose to galactose in the molecule is 4:1 32 . The in-vitro dissolution studies showed the release of 13-26 % for khaya formulation but at the end of 12 h, the value rose to between 50-81 % indicating that the tablets extended release for more than 12 h. For matrix tablet formulated with KLB (Khaya and Locust Bean Gum) polymer blend in 1:1 ratio, the initial release in the 1 st hour ranged from 18-83 %.…”