Osseoincorporation of Porous Tantalum Trabecular-Structured Metal: A Histologic and Histomorphometric Study in Humans

Arriba, Celia Clemente de; Gracia, M.A. Alobera; Coelho, Paulo G.; Neiva, Rodrigo; Tarnow, Dennis P.; Pingarrón, Mariano Del Canto; Aguado-Henche, Soledad

doi:10.11607/prd.3004

Cited by 18 publications

(9 citation statements)

References 28 publications

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“…This finding of mineralized and remodeled bone tissue at 2 weeks was consistent with samples retrieved from human subjects by Arriba et al. (). Nonetheless, a question has been raised as to whether the use of highly porous TM material in a dental implant design might pose an additional risk for peri‐implantitis compared to non‐porous implant designs (Bencharit et al., ).…”

Section: Discussionsupporting

confidence: 91%

“…The authors concluded that TM material promoted bone ingrowth for secondary implant stability and suggested that it may also possess a capacity to resist peri‐implant inflammation (Spinato et al., ). Although other research has suggested that bacterial adhesion rates are relatively similar between tantalum and titanium (Levon et al., ; Schildhauer, Robie, Muhr & Köller, ), progressive angiogenesis has been observed (Arriba et al., ) inside TM material retrieved from human subjects from 2 to 12 weeks, which may provide a pathway for delivering antibiotics to the internal network of pores inside TM material. Prospective clinical studies are needed, however, before any definitive conclusions can be reached.…”

Section: Discussionmentioning

confidence: 96%

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New bone formation and trabecular bone microarchitecture of highly porous tantalum compared to titanium implant threads: A pilot canine study

Lee

Wen

Gubbi

et al. 2017

Clinical Oral Implants Res

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AimThis study evaluated new bone formation activities and trabecular bone microarchitecture within the highly porous region of Trabecular Metal™ Dental Implants (TM) and between the threads of Tapered Screw‐Vent® Dental Implants (TSV) in fresh canine extraction sockets.Materials and methodsEight partially edentulated dogs received four implants (4.1 mmD × 13 mmL) bilaterally in mandibular fresh extraction sockets (32 TM, 32 TSV implants), and allowed to heal for 2, 4, 8, and 12 weeks. Calcein was administered to label mineralizing bone at 11 and 4 days before euthanasia for dogs undergoing all four healing periods. Biopsies taken at each time interval were examined histologically. Histomorphometric assay was conducted for 64 unstained and 64 stained slides at the region of interest (ROI) (6 mm long × 0.35 mm deep) in the midsections of the implants. Topographical and chemical analyses were also performed.ResultsHistomorphometry revealed significantly more new bone in the TM than in the TSV implants at each healing time (p = .0014, .0084, .0218, and .0251). Calcein‐labeled data showed more newly mineralized bone in the TM group than in the TSV group at 2, 8, and 12 weeks (p = .045, .028, .002, respectively) but not at 4 weeks (p = .081). Histologically TM implants exhibited more bone growth and dominant new immature woven bone at an earlier time point than TSV implants. The parameters representing trabecular bone microarchitecture corroborated faster new bone formation in the TM implants when compared to the TSV implants. TM exhibited an irregular faceted topography compared to a relatively uniform microtextured surface for TSV. Chemical analysis showed peaks associated with each implant's composition material, and TSV also showed peaks reflecting the elements of the calcium phosphate blasting media.Conclusions and clinical implicationsResults suggest that the healing pathway associated with the highly porous midsection of TM dental implant could enable faster and stronger secondary implant stability than conventional osseointegration alone; however, prospective clinical studies are needed to confirm these potential benefits in patients with low bone density, compromised healing, or prior implant failure.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 96%

New bone formation and trabecular bone microarchitecture of highly porous tantalum compared to titanium implant threads: A pilot canine study

Lee

Wen

Gubbi

et al. 2017

Clinical Oral Implants Res

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“…Therefore, the spongy bone like structure of porous Ta can be one explanation for its superior biological and mechanical property to many other metal materials in terms of rapid osseous ingrowth and bone-to-implant contact, both of which directly influence the survival rate of dental implants in the long run [162]. The histological and histomorphometric analysis has validated the osseoincorporation property of porous Ta implants derived from the rapid formation of vascularized bone tissues not only on the surface but also in the inner pores, which further reinforced the interlocking force between the implants and human jaws [163]. The canine model test revealed the porous Ta section could provide a more rapid new bone formation and stronger stability for the porous Ta enhanced titanium implants compared to its conventional screwed titanium counterparts [164].…”

Section: Dental Implantsmentioning

confidence: 86%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

Huang¹,

Pan²,

Qiu³

2021

Preprint

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone-implant stability in long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, low elastic modulus and high friction coefficient of porous Ta can effectively avoid stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta based implants or prostheses are mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta based implants or prostheses have shown their clinical value in the treatment of individual patient who need specially designed implant or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

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“…Previous studies have shown that Ta metal is a suitable bone substitute for clinical applications . However, the excessively high modulus of elasticity and the weight of the Ta metal itself hinder its widespread clinical application.…”

Section: Methodsmentioning

confidence: 99%

In Vitro and in Vivo Study of 3D-Printed Porous Tantalum Scaffolds for Repairing Bone Defects

Xie

Jiang

et al. 2018

ACS Biomater. Sci. Eng.

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Porous tantalum (Ta) scaffold is a novel implant material widely used in orthopedics including joint surgery, spinal surgery, bone tumor surgery, and trauma surgery. However, porous Ta scaffolds manufactured using the traditional method have many disadvantages. We used selective laser melting (SLM) technology to manufacture porous Ta scaffolds, and the pore size was controlled to 400 μm. The compressive strength and elastic modulus of the porous scaffolds were evaluated in vitro. To evaluate the osteogenesis and osseointegration of Ta scaffolds manufactured by SLM technology, cytocompatibility in vitro and osseointegration ability in vivo were evaluated. This porous Ta scaffold group showed superior cell adhesion and proliferation results of human bone mesenchymal stem cells (hBMSCs) compared with the control porous Ti6Al4V group. Moreover, the alkaline phosphatase (ALP) activity at day 7 and the semiquantitative analysis of Alizarin red staining at day 21 demonstrated that osteogenic differentiation of hBMSCs was enhanced in the Ta group. The porous Ta scaffold was implanted into a cylindrical bone defect with a height and diameter of 1 and 0.5 cm, respectively, in the lateral femoral condyle of New Zealand rabbits. Radiographic analysis showed that the new bone formation in Ta scaffolds was higher than that in Ti6Al4V scaffolds. Histological images indicated that compared with porous Ti6Al4V scaffolds, Ta scaffolds increased bone ingrowth and osseointegration. The porous Ta scaffold manufactured by SLM not only has a regular pore shape and connectivity but also has controllable elastic modulus and compressive strength. Moreover, the osteogenesis and osseointegration results in vitro and in vivo were improved compared with those of the porous Ti6Al4V scaffold manufactured using the same technology. These findings demonstrate that the porous Ta scaffold manufactured by SLM is potentially useful for orthopedic clinical application.

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Osseoincorporation of Porous Tantalum Trabecular-Structured Metal: A Histologic and Histomorphometric Study in Humans

Cited by 18 publications

References 28 publications

New bone formation and trabecular bone microarchitecture of highly porous tantalum compared to titanium implant threads: A pilot canine study

New bone formation and trabecular bone microarchitecture of highly porous tantalum compared to titanium implant threads: A pilot canine study

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

In Vitro and in Vivo Study of 3D-Printed Porous Tantalum Scaffolds for Repairing Bone Defects

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