Osseous metaplasia in an ulcerating tubular adenoma of the colon: a case report

Abstract

Introduction: Heterotopic bone is rarely found in the gastrointestinal tract. Here we report a rare case of metaplastic ossification within a benign ulcerating adenoma and review the literature concerning the aetiology.

Osseous Metaplasia in an Inflammatory Polyp of the Rectum: A Case Report and Review of the Literature

“…Seventeen cases have been reported in the reviewed literature ( Table 1 ).Of the previous cases, eight have been reported in polyps with low grade dysplasia; specifically three in tubular adenomas [ 1 - 3 ], four in tubulovillous adenomas [ 4 - 8 ], and one in a serrated adenoma [ 9 ]. One of the tubular adenomas occurred in the sigmoid colon [ 1 ], one was found in the transverse colon [ 2 ], and one was from an undisclosed site [ 3 ]. One of the tubulovillous adenomas was seen in the cecum [ 4 ], one was in the sigmoid [ 5 ], and one was in the rectum [ 6 , 7 ].…”

Ossification within an adenomatous polyp

“…The presence of ossification and heterotopic bone formation in adenomatous polyps has been reported previously in only eight cases [1,[6][7][8][9][10][11][12] (Table 1). Other benign polyps have included juvenile polyps [7,[13][14][15][16] (N = 9), inflammatory polyps [17,18] (N = 2), as well as in granulation tissue [19] (N = 1) and a hyperplastic polyp [20] (N = 1; Table 2).…”

Traditional serrated adenoma of the sigmoid colon with osseous metaplasia: a case report

“…One possible mechanism includes the production of bone morphogenetic proteins (BMP)-5 and BMP-6 by epithelial cells and BMP-2 and BMP-4 by adjacent fibroblasts [9-11,13,15,16]. …”