Ossifying fibroma of the jaws: Report of two cases and literature review

Gondivkar, Shailesh; Gadbail, Amol R.; Chole, Revant; Parikh, Rima V.; Balsaraf, Swati

doi:10.1016/j.oraloncology.2011.06.014

Cited by 49 publications

(87 citation statements)

References 42 publications

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“…The condition refers to a process in which normal bone is replaced with fibroblasts and collagen fibers containing varying amounts of mineralized material [2].…”

Section: Discussionmentioning

confidence: 99%

“…The juvenile OF is usually found in young patients (children and adolescents aged ≤ 15 years) and is known to be more aggressive, growing faster than OF with greater destructive power. This more aggressive variant is further subdivided into trabecular and psammomatoid juvenile OF -the first is associated with pediatric patients and usually involves the maxilla, while the second is associated with adolescents and adults and usually involves the orbit and paranasal sinuses [1][2][3]. True OF is relatively rare, since, for a long time, the lesions that were so diagnosed were in fact focal cemento-osseous dysplasias [1,2,4].…”

Section: Discussionmentioning

confidence: 99%

“…This benign fibroosseous tumor is most commonly found in the mandibular molar/premolar region and occurs predominantly in the third and fourth decades of life, affecting women more than men [1][2][3][4][5][6]. OF consists of intraosseous fibrous tissue that exhibits varying degrees of cellularity and contains mineralized material.…”

Section: Introductionmentioning

confidence: 99%

“…OF consists of intraosseous fibrous tissue that exhibits varying degrees of cellularity and contains mineralized material. It appears as a well-circumscribed lesion that may or may not be surrounded by a fibrous capsule [1,2,4].…”

Section: Introductionmentioning

confidence: 99%

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Ossifying fibroma – diagnosis, treatment, and follow-up: case report and literature review

Andriola

Zanettini

Barreiro

et al. 2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: This article presents a case of ossifying fibroma (OF), including its diagnosis, treatment, and 15-month clinical and radiographic follow-up as well as a review of the literature about this pathology. CASE REPORT: A routine panoramic radiograph of a 27-year-old, systemically healthy, white woman revealed a radiolucent lesion with well-defined sclerotic margins of approximately 3 × 2 cm in the mandible. The histopathological diagnosis revealed it was an OF. Lower Right Canine and Lower Right First Premolar teeth were endodontically treated for later surgical removal of the tumor. There was no history of trauma in the region. CONCLUSION: OF is a benign fibro-osseous tumor of the craniofacial bones commonly involving the jaws, especially the mandible. The diagnosis is based on a combination of clinical, radiographic and histologic criteria. Conservative treatment is an effective option that reduces morbidity and simplifies postoperative rehabilitation. We emphasize the importance of properly documenting individual cases and interpreting postoperative radiographic images along with the patients in order to avoid possible confusion between areas of bone repair and of potentially suspicious lesions in the future.Key words: Surgery, Oral; Pathology, Oral; Fibroma, Ossifying Fibroma ossificante -diagnóstico, tratamento e acompanhamento: relato de caso e revisão da literatura RESUMO OBJETIVO: Este artigo apresenta um caso de fibroma ossificante (OF), incluindo seu diagnóstico, tratamento e acompanhamento clínico e radiográfico de 15 meses, bem como uma revisão da literatura sobre esta patologia. RELATO DO CASO: Uma radiografia panorâmica de rotina de uma mulher branca de 27 anos, sistemicamente saudável, revelou uma lesão radiolúcida com margens escleróticas bem definidas de aproximadamente 3 × 2 cm na mandíbula. O diagnóstico histopatológico revelou que era um FO. O Canino Inferior Direito e o Pré-Molar Inferior Direito foram tratados endodonticamente para posterior remoção cirúrgica do tumor. Não havia história de trauma na região. CONCLUSãO: O FO é um tumor fibro-ósseo benigno dos ossos craniofaciais que comumente envolve os ossos maxilares, especialmente a mandíbula. O diagnóstico é baseado em uma combinação de critérios clínicos, radiográficos e histológicos. O tratamento conservador é uma opção eficaz que reduz a morbidade e simplifica a reabilitação pós-operatória. Ressaltamos a importância de uma adequada documentação dos casos, bem como do esclarecimento sobre a evolução das imagens radiográficas pós-operatórias junto aos pacientes, de modo a evitar possíveis confusões entre as áreas de reparo ósseo e suspeitas de novas lesões no futuro.

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“…The condition refers to a process in which normal bone is replaced with fibroblasts and collagen fibers containing varying amounts of mineralized material [2].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ossifying fibroma – diagnosis, treatment, and follow-up: case report and literature review

Andriola

Zanettini

Barreiro

et al. 2017

Rev. Odonto Ciênc. (Online)

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“…The clinical course of the tumor varies from indolent to aggressive progression. 3 Generally, it is slow-growing and incidentally diagnosed by routine dental examinations, but in some instances, it can be destructive, causing facial deformity, sinus obstruction, proptosis, infection and intracranial complications, as a result of which complete surgical removal is needed. 4 Fibrous dysplasia is a benign dysplastic disease of the bone, which occurs in three forms: monostotic fibrous dysplasia, which involves one bone; polyostotic fibrous dysplasia, which affects multiple bones; and McCune-Albright syndrome, in which polyostotic fibrous dysplasia is accompanied by cafe-au-lait spots or hyperfunctioning endocrinopathies.…”

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confidence: 99%

GNAS mutational analysis in differentiating fibrous dysplasia and ossifying fibroma of the jaw

Shi

Zhang

et al. 2013

Modern Pathology

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Differential diagnosis of fibrous dysplasia and ossifying fibroma may often pose problems for pathologists. The purpose of this study was to evaluate the value of mutational analysis of the GNAS gene in differentiating these two conditions. DNA samples from patients with fibrous dysplasia (n ¼ 30) and ossifying fibroma (n ¼ 21) were collected to analyze the presence of GNAS mutations at exons 8 and 9, the two previously reported hotspot regions, using polymerase chain reaction and direct sequencing. In all, 90% (27/30) of cases with fibrous dysplasia showed missense mutations of codon 201 at exon 8, with a predilection of arginine-to-histidine substitution (p.R201H, 70%) as opposed to arginine-to-cysteine substitution (p.R201C, 30%), whereas no mutation was detected at exon 9. No mutation was found in all 21 cases with ossifying fibroma. In addition, a meta-analysis of previously published reports on GNAS mutations in fibrous dysplasia and ossifying fibroma was performed to substantiate our findings. A total of 24 reports including 307 cases of fibrous dysplasia and 23 cases of ossifying fibroma were reviewed. The overall incidence of GNAS mutations in fibrous dysplasia was 86% (264/307), and the major types of mutations were also R201H (53%) and R201C (45%). No GNAS mutation was detected in all patients with ossifying fibroma. We also reported one case with uncertain diagnosis due to overlapping clinicopathological features of fibrous dysplasia and ossifying fibroma. An R201H mutation was detected in this case, thus confirming a diagnosis of fibrous dysplasia. Taken together, our findings indicate that mutational analysis of GNAS gene is a reliable adjunct to differentiate ossifying fibroma and fibrous dysplasia of the jaws.

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Fast Growing Bony Hard Lump: Cemento-ossifying Fibroma

Kallarakkal

Ngeow

2023

Clinicopathological Correlation of Oral Diseases

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Ossifying fibroma of the jaws: Report of two cases and literature review

Cited by 49 publications

References 42 publications

Ossifying fibroma – diagnosis, treatment, and follow-up: case report and literature review

Ossifying fibroma – diagnosis, treatment, and follow-up: case report and literature review

GNAS mutational analysis in differentiating fibrous dysplasia and ossifying fibroma of the jaw

Fast Growing Bony Hard Lump: Cemento-ossifying Fibroma

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