Ossifying Fibromyxoid Tumor in the Mandibular Gingiva: Case Report and Review of the Literature

Nonaka, Cassiano Francisco Weege; Pacheco, Domingos F.S.; Nunes, Rodrigo P.A.; Freitas, Roseana de Almeida; Miguel, Márcia Cristina da Costa

doi:10.1902/jop.2009.080535

Cited by 21 publications

(13 citation statements)

References 19 publications

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“…The tumor is most commonly encountered in adults, males more often than females. The extremities and trunk are the most common locations, 1 however; other unusual locations like head and neck, [2][3][4][5][6][7][8][9] and subcutaneous 10 locations, have also been described. The majority of cases behave in a clinically benign fashion, however; a small percentage of tumors may locally recur or metastasize.…”

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Ossifying fibromyxoid tumor: Report of a case with cytomorphologic description

Ahmed

Qasem

Salih

2015

Diagnostic Cytopathology

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Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm with uncertain histogenesis. Most cases behave in a clinically benign fashion; however, a small percentage of tumors may locally recur or metastasize. Herein we present a case of a 56-year-old man who presented with an enlarging left groin mass, left inner thigh numbness, burning paresthesia and discomfort in his left groin. The mass sampled by fine- needle aspiration and needle core biopsy. Cytology showed bland-appearing epithelioid cells with round nuclei and fine chromatin, with fragments of fibromyxoid stroma in the background. Immunohistochemical stains performed on the core biopsy showed that the lesional cells were focally positive for S100 protein and negative for desmin, smooth muscle actin, CD34 and cytokeratin AE1/AE3. A benign neoplasm was favored with ossifying fibromyxoid tumor as the main entity in the differential diagnosis. A subsequent resection showed a well-circumscribed 5 cm mass with firm consistency and focal areas of calcifications. Histologically, the tumor had a nodular growth pattern with relatively bland spindle cells containing round to oval nuclei suspended in a variably collagenous to myxoid stroma. Significant ossification and bone formation was also noted. There was no significant atypia, necrosis or increased mitoses. Ossifying fibromyxoid tumors have distinct cytologic features and should be considered in the differential diagnosis of soft tissue tumors with prominent ossification.

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Ossifying fibromyxoid tumor: Report of a case with cytomorphologic description

Ahmed

Qasem

Salih

2015

Diagnostic Cytopathology

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“…In the maxillofacial region, OFMT has been reported in the tongue, mandibular gingiva, soft and hard palate, buccal mucosa, mandible, and vestibules. It was cranially reported in the ethmoid sinus in a newborn as well [5,6]. Malignant transformation was reported in the tongue [7].…”

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confidence: 99%

Ossifying Fibromyxoid Tumor of the Posterior Maxilla: A Rare Case Report and Literature Review

Ottoman¹

2015

ICPJL

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This paper reports a very unusual site of ossifying fibromyxoid tumor (OFMT) and review the medical literature. In the maxillofacial region, OFMT has been rarely reported. However, malignant OFMT was recently traced in the tongue. Clinicians and maxillofacial pathologists should pay a rapt attention to such an innocent looking lesion that can be easily confused with the ossifying fibrous epulis. This holds true when OFMT is encountered in the gnathions.Keywords: Ossifying Fibromyxoid Tumor; Gnathic Lesions; Fibro-Osseous Lesions and trabeculae of ovoid cells swimming in a fibromyxoid stroma. OFMT was classified as "typical" and "atypical". Histologically, the presence of high cellularity or high nuclear grade, with mitotic activity >2 mitotic figures per 50 high power fields revealed a statistically significant potential for a malignant behavior. This find is characteristic of the so-called "atypical" OFMT. It proved not to be only potentially malignant, but also revealed 60% local recurrence rate and 60% metastasis incidence. Even in typical OFMT cases, the recurrence and metastatic rates, 17% and 5%, respectively, make it a lesion of intermediate malignancy. There are no specific immunohistochemical markers for OFMT. It shows a positive reactivity, sometimes, for S-100 and other bone markers [8]. ConsentWritten informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editorin-Chief of this journal.

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“…neoplasm reported in the oral cavity, the ossifying fibromyxoid tumor, often present with a peripheral rim of calcification and may exhibit calcifications between the lobules of the lesion [31,32]. However, ossifying fibromyxoid tumors are typically lobular with a fibrous capsule or pseudo capsule and are characterized by cells arranged in cords and nests distributed in a myxoid background, a pattern not seen in leiomyoma [31,32].…”

Section: Discussionmentioning

confidence: 99%

“…However, ossifying fibromyxoid tumors are typically lobular with a fibrous capsule or pseudo capsule and are characterized by cells arranged in cords and nests distributed in a myxoid background, a pattern not seen in leiomyoma [31,32]. Osseous choristoma, also known as soft tissue osteomas, are composed of well circumscribed masses of bone, often with well-developed haversian canals and fatty or hematopoietic marrow spaces.…”

Section: Discussionmentioning

confidence: 99%

Extensively Ossifying Oral Leiomyoma: A Rare Histologic Finding

Montague

Fitzpatrick

Islam

et al. 2013

Head and Neck Pathol

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Oral leiomyoma are rare neoplasms of the oral cavity. Ossification within leiomyoma is not unusual but is mostly reported in leiomyoma of the deep soft tissue. Ossifying leiomyoma is extremely rare in the head and neck. We identified a total of three cases of extensively ossified leiomyoma in the head and neck in the literature including lesions in the lateral pterygoid muscle and orbit. To the best of our knowledge, only one case of extensively calcified leiomyoma has been reported in the oral cavity. We present two such rare cases of oral leiomyoma with extensive intratumoral calcifications and ossification. Ossified leiomyoma should be considered in the differential diagnosis of calcified or hard/firm soft tissue masses in the oral cavity.

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Ossifying Fibromyxoid Tumor in the Mandibular Gingiva: Case Report and Review of the Literature

Cited by 21 publications

References 19 publications

Ossifying fibromyxoid tumor: Report of a case with cytomorphologic description

Ossifying fibromyxoid tumor: Report of a case with cytomorphologic description

Ossifying Fibromyxoid Tumor of the Posterior Maxilla: A Rare Case Report and Literature Review

Extensively Ossifying Oral Leiomyoma: A Rare Histologic Finding

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