Ossifying Fibromyxoid Tumor of Soft Parts

Enzinger, Franz M.; Weiss, Sharon W.; Liang, Chang Y.

doi:10.1097/00000478-198910000-00001

Cited by 254 publications

(31 citation statements)

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“…in 1989, in which, approximately 70% of the examined cases showed the subcutaneous tissue involvement in the lower or upper limbs, whereas OFMT in the head and neck region only accounted for about 13% of those cases [1]. Involvement in the oral cavity is extremely rare, with only 7 cases have reported in the soft palate, buccal mucosa, vestibule, lip, and gingiva (Table 2) [3,4,7-9].…”

Section: Discussionmentioning

confidence: 99%

“…Ossifying fibromyxoid tumor (OFMT) is an uncommon soft tissue neoplasm of uncertain origin, that is composed of relatively uniform round to ovoid cells often arranged in a corded or trabecular pattern and embedded in a fibromyxoid matrix [1-3]. In addition, a band of dense collagen with spicules of metaplastic bone is commonly encountered at the tumor periphery [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, a band of dense collagen with spicules of metaplastic bone is commonly encountered at the tumor periphery [1,2]. …”

Section: Introductionmentioning

confidence: 99%

“…OFMT mostly arises in subcutaneous tissue or skeletal muscle of the extremities, while it has been reported at other sites, such as the trunk, head and neck, mediastinum and retroperitoneum at low frequency [1,2,4-6]. However, this tumor located in the oral cavity is extremely rare [2-4,7-9], with no cases of OFMT arising in the tongue previously reported.…”

Section: Introductionmentioning

confidence: 99%

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Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature

Ohta¹,

Taki²,

Ogawa

et al. 2013

Head Face Med

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Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal neoplasm that arises in subcutaneous tissue, with that in the oral cavity extremely rare. We present a case of malignant OFMT in the tongue. A 26-year-old male noticed a painless mass in the tongue, which was extracted at a general hospital. Four years later, the tumor recurred and was resected at our department. Histologically, the recurrent tumor was composed of the closely packed cells positive for vimentin and S-100 proliferating in a nodular fashion. It showed high cellularity and mitotic activity. In the primary tumor, some tumor cells were arranged in a diffuse or cord-like manner within an abundant fibromyxoid matrix, along with a small amount of metaplastic ossification, corresponding with the histopathological characteristic of OFMT. Accordingly, a diagnosis of malignant OFMT arising in typical OFMT was established. This is the first reported case of malignant OFMT in the tongue. Long-term follow-up is needed for confirmation of prognosis and biological behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In addition, a band of dense collagen with spicules of metaplastic bone is commonly encountered at the tumor periphery [1,2]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature

Ohta¹,

Taki²,

Ogawa

et al. 2013

Head Face Med

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show abstract

“…5,30,37 Other soft tissue lesions resembling glomus tumor include leiomyoblastoma and the newly described fibromyxoid tumor of soft parts. 13 That tumor consistently comprises glomoid elements. 42 Most of these lesions express, however, S-100 protein, distinctly different from its consistent absence in glomus cells.…”

Section: Discussionmentioning

confidence: 99%