Osteoarthritis 2012 year in review: rehabilitation and outcomes

Roos, Ewa M.; Juhl, Carsten Bogh

doi:10.1016/j.joca.2012.08.028

Cited by 80 publications

(70 citation statements)

References 44 publications

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“…Much of OA disease progression is mediated by aberrant physiological interaction of the components of the musculoskeletal system, such as aberrant biomechanical forces or a pathologic response to these forces [49]. Many interventions, such as exercise and walking aids, are designed to correct abnormal physiology [50]. The physiologic aspect of disease is therefore an integral and important descriptor of OA.…”

Section: The Diseasementioning

confidence: 99%

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use

Kraus

Blanco

Englund

et al. 2015

Osteoarthritis and Cartilage

499

345

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Osteoarthritis is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for osteoarthritis (OA) that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of ROAD (Risk of Osteoarthritis Development) and ROAP (Risk of Osteoarthritis Progression) tools analogous to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages -- REDI (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for OA could spur development of disease modifying therapies for this entity that has proved so recalcitrant to date. We fully acknowledge that as we move forward, we expect to develop more sophisticated definitions, terminology and tools.

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Section: The Diseasementioning

confidence: 99%

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use

Kraus

Blanco

Englund

et al. 2015

Osteoarthritis and Cartilage

499

345

View full text Add to dashboard Cite

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“…Analgesics are frequently prescribed in combination with other non-pharmacological therapies to decrease the dependency on analgesics [1, 2, 5]. These therapies include exercise [8, 12], weight reduction [2, 5, 8] and other complimentary/alternative therapies [2, 5, 13]. …”

Section: Introductionmentioning

confidence: 99%

Pain management with acupuncture in osteoarthritis: a systematic review and meta-analysis

Manyanga

Froese

Zarychanski

et al. 2014

BMC Complement Altern Med

117

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BackgroundThe utility of acupuncture in managing osteoarthritis symptoms is uncertain. Trial results are conflicting and previous systematic reviews may have overestimated the benefits of acupuncture.MethodsTwo reviewers independently identified randomized controlled trials (up to May 2014) from multiple electronic sources (including PubMed/Medline, EMBASE, and CENTRAL) and reference lists of relevant articles, extracted data and assessed risk of bias (Cochrane’s Risk of Bias tool). Pooled data are expressed as mean differences (MD), with 95% confidence intervals (CI) (random-effects model).ResultsWe included 12 trials (1763 participants) comparing acupuncture to sham acupuncture, no treatment or usual care. We adjudicated most trials to be unclear (64%) or high (9%) risk of bias. Acupuncture use was associated with significant reductions in pain intensity (MD -0.29, 95% CI -0.55 to -0.02, I2 0%, 10 trials, 1699 participants), functional mobility (standardized MD -0.34, 95% CI -0.55 to -0.14, I2 70%, 9 trials, 1543 participants), health-related quality of life (standardized MD -0.36, 95% CI -0.58 to -0.14, I2 50%, 3 trials, 958 participants). Subgroup analysis of pain intensity by intervention duration suggested greater pain intensity reduction with intervention periods greater than 4 weeks (MD -0.38, 95% CI -0.69 to -0.06, I2 0%, 6 trials, 1239 participants).ConclusionsThe use of acupuncture is associated with significant reductions in pain intensity, improvement in functional mobility and quality of life. While the differences are not as great as shown by other reviews, current evidence supports the use of acupuncture as an alternative for traditional analgesics in patients with osteoarthritis.Systematic review registrationCRD42013005405.Electronic supplementary materialThe online version of this article (doi:10.1186/1472-6882-14-312) contains supplementary material, which is available to authorized users.

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“…Nowadays, various treatment options are available for the management of this condition. They include: nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management;4 bisphosphonates to decrease pain and improve functionality preserving the structural integrity of subchondral bone;5 therapeutic exercise;6 viscosupplementation with hyaluronic acid alone or in combination with bisphosphonates or NSAIDs to improve pain and functional activity7–9 since hyaluronic acid improves articular cartilage degeneration and decreases osteophyte formation, as showed by experimental studies using OA models 10,11. These treatment modalities are effective in reducing pain and inflammation, but their long-term administration is associated with a high incidence of side effects or may not be applicable to the elderly 12.…”

Section: Introductionmentioning

confidence: 99%

Pulsed electromagnetic field therapy for management of osteoarthritis-related pain, stiffness and physical function: clinical experience in the elderly

Iannitti¹,

Fistetto²,

Esposito³

et al. 2013

CIA

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BackgroundPulsed electromagnetic field (PEMF) therapy has shown promising therapeutic effectiveness on bone- and cartilage-related pathologies, being also safe for management of knee osteoarthritis.AimThe aim of this study was to investigate the clinical efficacy of a PEMF device for management of knee osteoarthritis in elderly patients.Materials and methodsA total of 33 patients were screened, and 28 patients, aged between 60 and 83 and affected by bilateral knee osteoarthritis, were enrolled in this study. They received PEMF therapy on the right leg for a total of three 30-minute sessions per week for a period of 6 weeks, while the left leg did not receive any treatment and served as control. An intravenous drip containing ketoprofen, sodium clodronate, glucosamine sulfate, calcitonin, and ascorbic acid, for a total volume of 500 mL, was administered during PEMF therapy. At baseline and 3 months post-PEMF therapy, Visual Analog Scale (VAS) was used to assess knee pain and Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) was used to measure knee pain, stiffness and physical function.ResultsChanges in VAS and WOMAC scores were calculated for both knees as baseline minus post-treatment. A two sample Student’s t-test, comparing change in knee-related VAS pain for PEMF-treated leg (49.8 ± 2.03) vs control leg (11 ± 1.1), showed a significant difference in favor of PEMF therapy (P < 0.001). A two sample Student’s t-test comparing change in knee-related WOMAC pain, stiffness, and physical function for PEMF-treated leg (8.5 ± 0.4, 3.5 ± 0.2, 38.5 ± 2.08, respectively) vs control leg (2.6 ± 0.2; 1.6 ± 0.1; 4.5 ± 0.5 respectively), also showed a significant difference in favor of PEMF therapy (P < 0.001). No adverse reactions to therapy were observed.ConclusionThe present study shows that PEMF therapy improves pain, stiffness and physical function in elderly patients affected by knee osteoarthritis.

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Osteoarthritis 2012 year in review: rehabilitation and outcomes

Cited by 80 publications

References 44 publications

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use

Pain management with acupuncture in osteoarthritis: a systematic review and meta-analysis

Pulsed electromagnetic field therapy for management of osteoarthritis-related pain, stiffness and physical function: clinical experience in the elderly

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