Osteoarthritis: a common disease that should be avoided in the athletic horse’s life

Baccarin, Raquel Yvonne Arantes; Seidel, Sarah Raphaela Torquato; Michelacci, Yára M.; Tokawa, Paula Keiko Anadão; Oliveira, Tiago Marcelo

doi:10.1093/af/vfac026

Cited by 14 publications

(13 citation statements)

References 65 publications

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“…Osteoarthritis is a common arthritis in veterinary medicine and poses considerable challenges to animal welfare. OA is well recognized as a significant clinical problem causing pain and disability in cats, dogs and horses [ 18 , 19 , 20 ]. In addition, equine OA is a significant cause of lameness and premature elimination of racehorses [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Combined detection of serum CTX‐II and C2C in a rat model of ACLT‐induced osteoarthritis

Bai

Zhang

et al. 2023

FEBS Open Bio

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Osteoarthritis (OA) is a chronic degenerative bone and joint disease that often occurs in aging animals. Currently, there are still no biomarkers that can effectively diagnose OA in the early stage. To identify possible biomarkers, here we examined changes in the expression of C‐telopeptide fragments of type II collagen (CTX‐II) and collagenase generated carboxy‐terminal neoepitope of type II collagen (C2C) in serum at different time points in an anterior cruciate ligament transection (ACLT)‐induced rat OA model. The serum levels of CTX‐II and C2C, and the OARSI score in the ACLT group were increased from week two until the end of the experiment. The AUC of the combined biomarkers was higher than that of CTX‐II or C2C alone. Moreover, serum levels of CTX‐II and C2C were positively correlated with the OARSI score. The results suggest that the combined detection of serum CTX‐II and C2C concentrations may have potential for assessing and diagnosing OA at early stages.

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Section: Discussionmentioning

confidence: 99%

Combined detection of serum CTX‐II and C2C in a rat model of ACLT‐induced osteoarthritis

Bai

Zhang

et al. 2023

FEBS Open Bio

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“…It causes pain, stiffness, swelling, and difficulty moving the affected joints. There are different types of arthritis, such as traumatic arthritis and septic arthritis (SA) [ 9 ]. Additionally, the inflammation of the tendon or peritendinous tissue, such as tendinitis or tenosynovitis, is of special interest.…”

Section: Introductionmentioning

confidence: 99%

“…Tendinitis is the inflammation of a tendon, which may predispose horses to future fiber ruptures with associated hemorrhages and oedemas. It is more common in horses performing high-impact and high-speed work, such as racehorses, as factors like excessive fatigue, tendon overextension, poor physical conditioning, poor racetrack conditions, improper shoeing, or joint malformations can predispose them to tendinitis [ 9 ]. Finally, tenosynovitis is the inflammation of the tendon sheath, which consists of a synovial membrane and a fibrous layer.…”

Section: Introductionmentioning

confidence: 99%

Regenerative Medicine Applied to Musculoskeletal Diseases in Equines: A Systematic Review

Pérez Fraile,

González-Cubero,

Martínez-Flórez

et al. 2023

Veterinary Sciences

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Musculoskeletal injuries in horses have a great economic impact, predominantly affecting tendons, ligaments, and cartilage, which have limited natural regeneration. Cell therapy, which uses mesenchymal stem cells due to their tissue differentiation properties and anti-inflammatory and immunoregulatory effects, aims to restore damaged tissue. In this manuscript, we performed a systematic review using the Parsifal tool, searching the PubMed and Web of Science databases for articles on regenerative medicine for equine musculoskeletal injuries. Our review covers 17 experimental clinical studies categorized by the therapeutic approach used: platelet-rich plasma, conditioned autologous serum, mesenchymal stem cells, and secretome. These therapies reduce healing time, promote regeneration of fibrocartilaginous tissue, improve cellular organization, and improve joint functionality and sustainability. In conclusion, regenerative therapies using platelet-rich plasma, conditioned autologous serum, equine mesenchymal stem cells, and the emerging field of the secretome represent a promising and highly effective approach for the treatment of joint pathologies in horses, implying a valuable advance in equine healthcare.

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“…In joint space, the mainly present cartilage is of the hyaline type; the latter is characterized by a low number of chondrocytes (CCs) immersed in an abundant extracellular matrix (ECM) and due to its poor vascularization, it has limited repair capacity [ 1 ]. Defects in joint cartilage can induce debilitating degenerative joint diseases such as osteoarthritis (OA), which represent one of the most common causes of lameness and can compromise the quality of life and performance of animals, particularly sport horses [ 2 , 3 , 4 ]. Joint cartilage injuries that exceed a dimension of 15 mm 2 turn out to be particularly critical because they cannot heal spontaneously [ 5 ] and can quickly evolve into a type of degenerative arthritis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Articular Cartilage Regeneration by Hyaline Chondrocytes: A Case Study in Equine Model and Outcomes

Canonici¹,

Cocumelli

Cersini

et al. 2023

Biomedicines

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Cartilage injury defects in animals and humans result in the development of osteoarthritis and the progression of joint deterioration. Cell isolation from equine hyaline cartilage and evaluation of their ability to repair equine joint cartilage injuries establish a new experimental protocol for an alternative approach to osteochondral lesions treatment. Chondrocytes (CCs), isolated from the autologous cartilage of the trachea, grown in the laboratory, and subsequently arthroscopically implanted into the lesion site, were used to regenerate a chondral lesion of the carpal joint of a horse. Biopsies of the treated cartilage taken after 8 and 13 months of implantation for histological and immunohistochemical evaluation of the tissue demonstrate that the tissue was still immature 8 months after implantation, while at 13 months it was organized almost similarly to the original hyaline cartilage. Finally, a tissue perfectly comparable to native articular cartilage was detected 24 months after implantation. Histological investigations demonstrate the progressive maturation of the hyaline cartilage at the site of the lesion. The hyaline type of tracheal cartilage, used as a source of CCs, allows for the repair of joint cartilage injuries through the neosynthesis of hyaline cartilage that presents characteristics identical to the articular cartilage of the original tissue.

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Osteoarthritis: a common disease that should be avoided in the athletic horse’s life

Cited by 14 publications

References 65 publications

Combined detection of serum CTX‐II and C2C in a rat model of ACLT‐induced osteoarthritis

Combined detection of serum CTX‐II and C2C in a rat model of ACLT‐induced osteoarthritis

Regenerative Medicine Applied to Musculoskeletal Diseases in Equines: A Systematic Review

Articular Cartilage Regeneration by Hyaline Chondrocytes: A Case Study in Equine Model and Outcomes

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