Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

Cannata, Francesca; Vadalà, Gianluca; Ambrosio, Luigi; Napoli, Nicola; Papalia, Rocco; Denaro, Vincenzo; Pozzilli, Paolo

doi:10.1002/dmrr.3254

Cited by 35 publications

(34 citation statements)

References 120 publications

(215 reference statements)

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“…Predominant features are articular cartilage damage and thinning, which are associated with chondrocyte hypertrophy, tissue inflammation, and extracellular matrix (ECM) degradation [3][4][5][6][7]. Major risk factors for OA include genetic predisposition, female gender, joint injury, and obesity [8].…”

Section: Introductionmentioning

confidence: 99%

Irisin Recovers Osteoarthritic Chondrocytes In Vitro

Vadalà

Giacomo

Ambrosio

et al. 2020

Cells

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Physical exercise favors weight loss and ameliorates articular pain and function in patients suffering from osteoarthritis. Irisin, a myokine released upon muscle contraction, has demonstrated to yield anabolic effects on different cell types. This study aimed to investigate the effect of irisin on human osteoarthritic chondrocytes (hOAC) in vitro. Our hypothesis was that irisin would improve hOAC metabolism and proliferation. Cells were cultured in growing media and then exposed to either phosphate-buffered saline (control group) or human recombinant irisin (experimental group). Cell proliferation, glycosaminoglycan content, type II/X collagen gene expression and protein quantification as well as p38/extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK), protein kinase B (Akt), c-Jun N-terminal kinase (JNK), and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) involvement were evaluated. Furthermore, gene expression of interleukin (IL)-1 and -6, matrix metalloproteinase (MMP)-1 and -13, inducible nitric oxide synthase (iNOS), and tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -3 were investigated following irisin exposure. Irisin increased hOAC cell content and both type II collagen gene expression and protein levels, while decreased type X collagen gene expression and protein levels. Moreover, irisin decreased IL-1, IL-6, MMP-1, MMP-13 and iNOS gene expression, while increased TIMP-1 and TIMP-3 levels. These effects seemed to be mediated by inhibition of p38, Akt, JNK and NFκB signaling pathways. The present study suggested that irisin may stimulate hOAC proliferation and anabolism inhibiting catabolism through p38, Akt, JNK, and NFκB inactivation in vitro, demonstrating the existence of a cross-talk between muscle and cartilage.

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Section: Introductionmentioning

confidence: 99%

Irisin Recovers Osteoarthritic Chondrocytes In Vitro

Vadalà

Giacomo

Ambrosio

et al. 2020

Cells

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“…The physical fitness term, refers to a series of attributes that can be achieved by training, such as endurance and strength, abilities that are closely related to PA [5]. However, PA in overweight or obese individuals with diabetes often represents an insurmountable problem since these subjects suffer of several musculoskeletal disorders such as osteoarthritis [10], chronic low back pain due to intervertebral disc degeneration [11], and other musculoskeletal disorders [12,13].…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Physical Activity in Diabetic Patients

Cannata

Vadalà

Russo

et al. 2020

JFMK

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One of the main goals of diabetic therapy is to achieve the best metabolic control to prevent the development and progression of potential complications. A multidisciplinary approach characterized by the combination of diet, physical activity (PA) and drug therapy with oral and injectable (non-insulin) pharmacological agents, is desirable to optimize metabolic control. The aim of this review is to explain the contribution of PA and its beneficial effects on patients affected by type 1 (T1D) and type 2 diabetes (T2D). We provide an overview of evidence on the effects of PA for the main two types of diabetes mellitus (DM) to identify the right level of PA to be recommended. We discuss the physiological and clinical role of PA in people with DM. It can be concluded that the objective of antidiabetic therapy should be the achievement and optimization of metabolic control through a multidisciplinary approach involving non-pharmacological therapy such as diet and PA, which has a crucial role.

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“…11,17,20,22 Fasting glucose was used as a measuring parameter in most studies. 11,[15][16][17][18][19][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Three out of the thirteen studies measured OGTT as a parameter. 11,18,19 In order to determine insulin resistance, eight studies performed fasting insulin test as a secondary outcome.…”

Section: Sample Size and Characteristicsmentioning

confidence: 99%

The Effect of Glucosamine With or Without Chondroitin Sulphate on Glucose Monitoring Parameters in Humans – A Systematic Review

Menon¹,

Hashim²,

Zainal³

et al. 2021

JYP

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Musculoskeletal diseases that included OA was the second greatest contributor to disability as measured by years lived with disability. The goals of OA treatment are to reduce pain, improve function and quality of life and decrease disability. The objective of this systematic review is to summarise the findings of the effect of glucosamine with or without chondroitin sulphate on glucose monitoring parameters in humans. An English language literature search of electronic bibliographic databases such as Medline, Web of Science, Science Direct, Scopus and Cochrane since inception to June 2020 was conducted. Two reviewers independently analysed the studies for quality and content using the Downs and Black Checklist. The thirteen studies that were included in the review consists of randomised control trials (n=7), non-randomised control trials (n=3), prospective cohort studies (n=2) and pre-post studies (n=1). Five studies detected the effect of glucosamine on glucose parameters. Studies that recruited patients with baseline impaired glucose tolerance or insulin resistance were more likely to detect an effect on glucose metabolism. Patients taking glucosamine have a higher risk of diabetes especially those who have high baseline glucose levels or have diabetes or have impaired glucose tolerance. Only two studies investigated the effect of glucosamine on glucose parameters in patients having osteoarthritis.

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Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

Cited by 35 publications

References 120 publications

Irisin Recovers Osteoarthritic Chondrocytes In Vitro

Irisin Recovers Osteoarthritic Chondrocytes In Vitro

Beneficial Effects of Physical Activity in Diabetic Patients

The Effect of Glucosamine With or Without Chondroitin Sulphate on Glucose Monitoring Parameters in Humans – A Systematic Review

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