Osteoarthritis complications and the recent therapeutic approaches

Abdel-Aziz, Manal A; Ahmed, Helmy; El‐Nekeety, Aziza A.; Abdel-Wahhab, Mosaad A.

doi:10.1007/s10787-021-00888-7

Cited by 16 publications

(9 citation statements)

References 149 publications

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“…The antimicrobial activity of the test agent was determined by measuring the diameter of zone of inhibition expressed in millimeter (mm). The experiment was carried out more than once and mean of reading was recorded [16][17][18][19]. The micro-organisms were obtained from Northern Utilization Research and Development Division, United State Department of Agriculture, Peoria, Illinois, USA.…”

Section: Antimicrobial Activity Evaluationmentioning

confidence: 99%

“…, and ellagic acid (9), coumaric acid (10), vanillin (11), ferulic acid (12), naringenin (13), taxifolin (14), cinnamic acid (15), kaempferol (16) were used in this study…”

Section: Free Radical Antioxidant Activity (2 2-diphenyl-1picrylhydra...mentioning

confidence: 99%

“…Figure 9: High performance liquid chromatography chromatogram of 16 standard phenolic compounds; ; gallic ac id (1), chlorogenic acid (2), catechin (3), methyl gallate (4), coeffic acid (5), syringic acid (6), pyrocatechol(7), rutin(8), and ellagic acid (9), coumaric acid(10), vanillin(11), ferulic acid(12), naringenin (13), taxifolin(14), cinnamic acid(15), kaempferol(16) …”

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confidence: 99%

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High‑Performance Liquid Chromatography‑Fingerprint Analyses, In vitro Cytotoxicity, Antimicrobial and Antioxidant Activities of the Extracts of Ceiba speciosa Growing in Egypt

et al. 2021

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Background: Cancer diseases and microbial resistance are serious health diseases related to oxidative stress and infectious diseases. The risk can be reduced by using plants rich in polyphenols. Methodology: Different solvent extracts from leaves of Ceiba speciosa (C.s) were evaluated for their biological and chemical activities. Also, the chemical profiles were investigated via high-performance liquid-chromatography (HPLC) -fingerprint analyses. Results: the leaves from Ceiba speciosa collected from the Zoo garden in Egypt, showed a moderate cytotoxicity against HepG2 in extracts; petroleum ether, ethyl acetate, dichloromethane, while weak-cytotoxicity in butanol, methanol extracts and non-cytotoxicity in water extract. Moreover, high antimicrobial activities were showed within dichloromethane, petroleum ether extracts, while a moderate antimicrobial activities were showed in methanol, ethyl acetate extracts, and low antimicrobial activities were showed in both of butanol and water extracts. On the other side, a strong antioxidant activities were recorded within extracts; dichloromethane and methanol while the least antioxidant activity was recorded within water extract. High-performance liquid-chromatography (HPLC) -fingerprint analyses is done for all fractions, this finding provides an insight into the usage of the tested species as a source of naturally occurring cytotoxic, antimicrobial and antioxidant agents

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Section: Antimicrobial Activity Evaluationmentioning

confidence: 99%

“…, and ellagic acid (9), coumaric acid (10), vanillin (11), ferulic acid (12), naringenin (13), taxifolin (14), cinnamic acid (15), kaempferol (16) were used in this study…”

Section: Free Radical Antioxidant Activity (2 2-diphenyl-1picrylhydra...mentioning

confidence: 99%

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confidence: 99%

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High‑Performance Liquid Chromatography‑Fingerprint Analyses, In vitro Cytotoxicity, Antimicrobial and Antioxidant Activities of the Extracts of Ceiba speciosa Growing in Egypt

et al. 2021

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase-2 inhibitors and acetaminophen are used clinically for symptomatic relief. However, they cannot effectively prevent the progression of OA ( Abdel-Aziz et al, 2021 ; Zhang et al, 2021b ). Patients with severe OA eventually require arthroplasty.…”

Section: Introductionmentioning

confidence: 99%

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo

Jiang

Lü

et al. 2022

Front. Pharmacol.

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Osteoarthritis (OA) is a common degenerative joint disease. Effective drugs that can halt or decelerate osteoarthritis progression are still lacking. Omaveloxolone is a semisynthetic oleanane triterpenoid exerting antioxidative and anti-inflammatory effects. The present study aims to determine whether omaveloxolone has a therapeutic effect on OA. Chondrocytes were treated with interleukin (IL)-1β to establish an OA cell model in vitro. Indicators of cell viability, oxidative stress, inflammation, cell apoptosis and extracellular matrix (ECM) degradation were investigated. Proteins related to the Nuclear factor erythroid derived-2-related factor 2 (Nrf2)/antioxidant response element (ARE) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling pathways were assessed using Western blotting. A destabilized medial meniscus surgery-induced OA rat model was used in vivo. Gait analysis, microcomputed tomography analysis, and histopathological and immunohistochemical analyses were performed to determine the therapeutic effect of omaveloxolone on attenuating osteoarthritis in vivo. The results showed that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signalling pathway and inhibition of the NF-κB signalling pathway in chondrocytes in vitro and attenuates OA progression in vivo, suggesting that omaveloxolone may be a potential therapeutic agent for OA.

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“…The main clinical manifestations are joint pain, short-term morning stiffness, and limited range of motion. [ 1 ] Due to the prolonged life expectancy of human beings, the incidence of OA and the burden of OA have been increasing. [ 2 ] It is common in adults > 65 years old and is the main cause of global disability.…”

Section: Introductionmentioning

confidence: 99%

Efficacy, residual effectiveness and safety of diacerein in the treatment of knee osteoarthritis: A meta-analysis of randomized placebo-controlled trials

Zhang

et al. 2022

Medicine

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Background: Osteoarthritis (OA) is the leading cause of disability in the elderly. Prevention and treatment of OA have become an urgent global demand. The pharmacologic role of diacerein in the treatment of osteoarthritis is controversial. We systematically reviewed the efficacy, safety, and residual effectiveness of diacerein.Objectives: To estimate the symptomatic efficacy, residual effect and safety of diacerein in the treatment of knee osteoarthritis, using a meta-analysis of published randomized controlled trials (RCTs).Methods: On December 1, 2021, we searched PubMed Medline, Web of Science, Cochrane Library databases, Wan Fang Medical Database, and National Knowledge Infrastructure. This study followed the inclusion criteria of the principle P(Population), I(Intervention), C(Comparison), O(Outcome), S (Study design) principle. All studies were randomized controlled trials of knee osteoarthritis. Cochrane bias risk assessment tool was used to assess the risk of bias. Meta-analyses were performed using a random-effects model. To explore sources of heterogeneity, subgroup analysis, sensitivity analysis, regression analysis and publication bias analysis were performed. Drug side effects with complete data were extracted from the included articles and then a combined analysis of these data was performed.Results: Eight studies were eligible and were included in our analysis (N = 1277 participants). All studies were randomized controlled trials of knee osteoarthritis. There was no significant difference in reduction of joint pain and improvement of function between diacerein and the control group. However, subgroup analysis suggested, compared with the placebo group, diacerein treatment yielded an improved mean reduction in visual analogue scale score of-0.44% (95% confidence interval [CI]-0.79 to 0.09), an improved the western Ontario and McMaster universities (physical function) score of -0.44% (95% CI-0.72 to -0.12). Follow-up analysis after discontinuation showed that diacerein treatment had a significant residual effect (95% CI-0.81 to-0.24). Data on drug side effects described in the included articles were extracted for statistical analysis. There was an increased risk of diarrhea with diacerein (Risk Ratio [RR] = 1.95 [1.03 to 2.47]) and withdrawal event from therapy (RR = 0.93 [0.75 to 1.15]).Conclusion: Diacerein might be considered an effective drug for the treatment of patients with KOA, showing short-term residual effectiveness. Although it is associated with an increased risk of diarrhea, the adverse event is mostly tolerable.Abbreviations: CI = confidence interval, NSAIDs = Non-steroidal anti-inflammatory drugs, OA = osteoarthritis, RCT = randomized controlled trial, RR = Risk Ratio, SMD = standardized mean difference, VAS = visual analogue scale, WOMAC = the western Ontario and McMaster universities.

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Osteoarthritis complications and the recent therapeutic approaches

Cited by 16 publications

References 149 publications

High‑Performance Liquid Chromatography‑Fingerprint Analyses, In vitro Cytotoxicity, Antimicrobial and Antioxidant Activities of the Extracts of Ceiba speciosa Growing in Egypt

High‑Performance Liquid Chromatography‑Fingerprint Analyses, In vitro Cytotoxicity, Antimicrobial and Antioxidant Activities of the Extracts of Ceiba speciosa Growing in Egypt

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo

Efficacy, residual effectiveness and safety of diacerein in the treatment of knee osteoarthritis: A meta-analysis of randomized placebo-controlled trials

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