Osteoblast function on nanophase alumina materials: Influence of chemistry, phase, and topography

Price, Rachel L.; Gutwein, Luke G.; Kaledin, Leonid A.; Tepper, F.; Webster, Thomas J.

doi:10.1002/jbm.a.20011

Cited by 131 publications

(95 citation statements)

References 27 publications

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“…The Ca/P composition ratio of the mineral-like tissue was 1.63 which corresponds well with the biological hydroxyapatite value (Figure 7b). These results show that mineralization was not affected by the ZnAl 2 O 4 composition of the films and the mineral deposition enhance was in concordance with previous studies of zinc-containing biomaterials that had shown an osteoconductive material for bone-related tissue engineering applications [40][41][42][43] .…”

Section: Resultssupporting

confidence: 92%

In vitro studies of osteoblasts response onto zinc aluminate ceramic films

et al. 2009

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Zinc based or doped ceramics have shown to be capable of increasing osteoblasts proliferation, biomineralization and bone formation. However, studies regarding the biological applications processes in ZnAl 2 O 4 ceramic films are very scarce. For this reason, the objective of this in vitro study was to investigate the response of osteoblasts cells cultured onto ZnAl 2 O 4 films. Our results showed a good biological response related to attachment and viability, with good cell morphology attached to the semi-spherical grains of the ceramic and the analysis of mineral-like tissue showed a high quantity of mineral deposited and organized as tiny spherical-like nodules attached to nanostructure surface of ZnAl 2 O 4 material films. Based in our results, ZnAl 2 O 4 films stimulated the bioactivity of osteoblasts cells and provide a microenvironment that favors cell differentiation and mineralization processes, suggesting their potential use as osteoconductive coating onto currently orthopedic and dental implants.

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Section: Resultssupporting

confidence: 92%

In vitro studies of osteoblasts response onto zinc aluminate ceramic films

et al. 2009

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“…Ball-like, bar-like, and plate-like α-Al 2 O 3 are widely used as heat-insulating materials and as reinforcements for composites [4]. Moreover, alumina is also used for dental materials or orthopedic devices because of its good biocompatibility [5][6]. Thus, the synthesis of boehmite with a given morphology has attracted considerable interest.…”

Section: Introductionmentioning

confidence: 99%

Precipitation of spherical boehmite from concentrated sodium aluminate solution by adding gibbsite as seed

Liu

et al. 2017

Int J Miner Metall Mater

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Abstract:The precipitation of spherical boehmite was studied by surface energy calculations, measurements of precipitation ratios, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The surface energy calculation results show that the (001) and (112) planes of gibbsite surfaces are remarkably stable because of their low surface energies. In addition, the (010) plane of boehmite grows preferentially during precipitation because of its low surface energy. Thus, we propose a method to precipitate spherical boehmite from a supersaturated sodium aluminate solution by adding gibbsite as seed in a heterogeneous system. In this method, gibbsite acts as the preliminary seed and saturation modifier. The results show that the fine boehmite first nucleates on the (001) and (112) planes of gibbsite and then grows vertically on the (001) and (112) basal planes of gibbsite via self-assembly, thereby forming spherical boehmite. Simultaneously, gibbsite is dissolved into the aluminate solution to maintain the saturation for the precipitation of boehmite. The precipitation ratio fluctuates (forming an M-shaped curve) because of gibbsite dissolution and boehmite precipitation. The mechanism of boehmite precipitation was further discussed on the basis of the differences in surface energy and solubility between gibbsite and boehmite. This study provides an environmentally friendly and economical method to prepare specific boehmite in a heterogeneous system.

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“…Later, tailoring the surface functionalities and the geometry of the scaffold garnered much attention in developing a scaffold that mimics the topography of the extracellular matrix. The integration of the nano-geometrical features and appropriate functional groups on the biomimetic scaffold produced better results when compared to the twodimensional cultures initially attempted [9,10,11]. This particular aspect continues to be the most investigated facet in tissue engineering at present.…”

Section: The Evolution Of Tissue Engineeringmentioning

confidence: 99%

The Integration of Nanotechnology and Biology for Cell Engineering: Promises and Challenges

Krishnan

Sethuraman

2013

Nanomaterials and Nanotechnology

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Introduction: Successful tissue engineering strategies leading to the regeneration of a tissue depend on many factors, starting from the choice of appropriate scaffold material, tailoring the surface functionalities and topography, providing the correct amount of chemical and mechanical stimuli at the appropriate time points, and ensuring the uniform and precise localization of cells. Further challenges arise when more than one cell type has to be employed for the effective regeneration of an organ. Importance: Though the use of nanomaterials has improved tissue engineering, many pitfalls still exist that present a roadblock in the translation of tissue engineering strategies to clinical practice. Apart from employing different materials with distinct surface functionalities and mechanical properties, various strategies have been employed to manipulate the surface topography and chemistry of scaffolds to create a biomimetic microenvironment for effective tissue regeneration. Conclusion: This review provides information about the factors influencing tissue engineering, namely geometry, chemistry, mechanics and cells, and the emerging concepts that may well represent the future of regenerative medicine. Electrospinning techniques and their variants, self-assembly, cell-printing techniques and cell sheet engineering, have all been elaborated in detail. These novel techniques may serve to overcome the challenges currently faced in tissue engineering.

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Osteoblast function on nanophase alumina materials: Influence of chemistry, phase, and topography

Cited by 131 publications

References 27 publications

In vitro studies of osteoblasts response onto zinc aluminate ceramic films

In vitro studies of osteoblasts response onto zinc aluminate ceramic films

Precipitation of spherical boehmite from concentrated sodium aluminate solution by adding gibbsite as seed

The Integration of Nanotechnology and Biology for Cell Engineering: Promises and Challenges

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