2020
DOI: 10.3390/cells9092073
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Osteoblast-Osteoclast Communication and Bone Homeostasis

Abstract: Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through secretory proteins. A direct interaction between osteoblasts and osteoclasts allows bidirectional transduction of activation signals through EFNB2-EPHB4, FASL-FAS or SEMA3A-NRP1, regulating differentiation and survival of osteoblasts … Show more

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Cited by 705 publications
(571 citation statements)
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References 98 publications
(118 reference statements)
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“…Osteocytes secrete many signaling molecules that both positively and negatively affect bone remodeling. ( 18 ) They are a major source of RANKL promoting osteoclastogenesis, ( 19 ) as well as sclerostin and DKK1, which antagonize WNT signaling and inhibit osteoblast bone formation. ( 14 ) The bone marrow holds many cell types such as those of hematopoietic lineages including myeloid (osteoclast precursor), lymphoid, and erythroid cells, as well as marrow stromal cells and BMSCs that can differentiate into osteoblasts, adipocytes, and chondrocytes.…”
Section: Bone Remodeling and Agingmentioning
confidence: 99%
“…Osteocytes secrete many signaling molecules that both positively and negatively affect bone remodeling. ( 18 ) They are a major source of RANKL promoting osteoclastogenesis, ( 19 ) as well as sclerostin and DKK1, which antagonize WNT signaling and inhibit osteoblast bone formation. ( 14 ) The bone marrow holds many cell types such as those of hematopoietic lineages including myeloid (osteoclast precursor), lymphoid, and erythroid cells, as well as marrow stromal cells and BMSCs that can differentiate into osteoblasts, adipocytes, and chondrocytes.…”
Section: Bone Remodeling and Agingmentioning
confidence: 99%
“…This finding indicates that TXA does not directly affect osteoblasts or their precursors but mediates their effects through other cell types found within the bone marrow. Although we cannot provide direct experimental evidence, it could be possible that TXA modulates cell-to-cell communications between osteoblasts and other bone marrow cells present in these cultures [ 21 ]. Among others, these include macrophages and osteoclast precursors, which have been shown to be of crucial importance in regulating osteoblast differentiation and function through the alteration of membrane-bound and soluble factors [ 22 , 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…Osteocytes are one of the most abundant cell types in the bone tissue and contribute to sensing mechanical load [19], through their extensive network of lacuna-canalicular area amounting to 215m 2 [20]. Osteocytes may positively or negatively regulate bone remodeling [21], a dynamic which tilts to a negative regulation with aging during which the lacunar density declines [22].…”
Section: Biology Of Skeletal Agingmentioning
confidence: 99%