Osteoblastic metastases in carcinoma of pancreas

Unusual Osteoblastic Metastases in the Spine Secondary to Adenocarcinoma of the Pancreas

“…It is well known that osteoblastic metastases are a valuable radiological sign for carcinomas of the prostate, breast, lung, and gastrointestine, but there are only very few isolated case reports of purely osteoblastic metastases secondary to adeno carcinoma of the pancreas (2,3). Pancreatic cancer has been reported to metastasize to bone in less than 15% of cases, most of which are mainly osteolytic (4,5).…”

Pancreatic cancer's initial presentation: back pain due to osteoblastic bone metastasis

“…A bone biopsy may be required to confirm or exclude the presence of metastasis and rule out other causes of sclerosis. From the different types of pancreatic cancer, it should be the ones of the tail or the body that should be considered, since the cancer of the head of the pancreas presents usually with obstructive jaundice (Gillison et al . 1970; Hatfield et al .…”

“…The mechanism that the pancreatic cancer metastasizes to the bones is still unclear (Gillison et al . 1970; Peavy et al .…”

“…A review of the literature indicates that bone metastases from pancreatic cancer are almost invariably osteolytic, with only rare exceptions of osteoblastic metastases (Gillison et al . 1970; Joffe & Antonioli 1978; Simon & Bartucci 1986; Mao et al .…”