Osteocalcin and its forms respond similarly to exercise in males and females

Hiam, Danielle; Landen, Shanie; Michaux, Jacques; Voisin, Sarah; Alvarez-Romero, Javier; Byrnes, Elizabeth; Chubb, Paul; Levinger, Itamar; Eynon, Nir

doi:10.1016/j.bone.2020.115818

Cited by 29 publications

(20 citation statements)

References 87 publications

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“…Additionally, recent research revealed no sex differences concerning the response of osteocalcin and its forms to high-intensity interval training [ 44 ], whereby in this study, only a short-term increase in TOC and ucOC could be observed in both sexes. Consequently, the authors emphasized the importance of regular training [ 44 ]. In contrast to results from our study, we could only demonstrate the relation of weekly resistance training, MA, and TOC in male subjects.…”

Section: Discussioncontrasting

confidence: 64%

Investigation of the Relationship between the Mid_Thigh Adipose Tissue Distribution Measured by MRI and Serum Osteocalcin—A Sex-Based Approach

Hassler

Almer²,

Reishofer

et al. 2021

Nutrients

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Osteocalcin, in its non-carboxylated form, has a positive effect on glucose metabolism. Additionally, osteocalcin levels are related to body composition, especially muscle mass. The relation to the distribution of different adipose tissue types, such as subcutaneous, intermuscular, and visceral adipose tissue, is unclear. This study aimed to investigate associations between serum osteocalcin and the distribution of subcutaneous and intermuscular adipose tissue of the mid-thigh. Furthermore, the influence of different training methods on osteocalcin levels was investigated. We performed adipose tissue quantification of subcutaneous adipose tissue (SAT) and intramuscular adipose tissue (IMAT) using MRI measurements of the mid-thigh in 128 volunteers (63 male/65 female). Laboratory analysis included blood lipid panel, serum insulin, adiponectin, and osteocalcin measurements. The main observation was a significant correlation of total serum osteocalcin (TOC) and the distribution of adipose tissue of the mid-thigh (SAT/(SAT + IMAT)) (cc = −0.29/p-value = 0.002), as well as the cross-sectional muscle area (MA), increasing with the weekly resistance training duration in males. Additionally, TOC (p-value = 0.01) and MA (p-value = 0.03) were negatively related to serum insulin. The significant relationship between TOC and SAT/(SAT + IMAT) is a new finding and confirms the negative influence of IMAT on glucose metabolism in a sex-specific approach. We could substantiate this by the negative relation of TOC with serum insulin.

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Section: Discussioncontrasting

confidence: 64%

Investigation of the Relationship between the Mid_Thigh Adipose Tissue Distribution Measured by MRI and Serum Osteocalcin—A Sex-Based Approach

Hassler

Almer²,

Reishofer

et al. 2021

Nutrients

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show abstract

“…In addition, OC stimulates pancreatic β-cell proliferation in cultured human islets ( 30 ). In accordance with previous animal studies, two meta-analyses confirmed that lower OC levels were observed in patients with type 2 diabetes than in normal controls ( 7 , 31 ) and acknowledged that OC was negatively associated with fasting plasma glucose levels, HbA1c, insulin resistance and body mass index (BMI) but positively correlated with improved glycemic control, weight loss and regular exercise ( 11 , 12 ).…”

Section: Discussionsupporting

confidence: 85%

“…To date, almost human studies have supported the findings of animal studies. In humans, serum OC was reported to be decreased in patients with type 2 diabetes compared to the levels in nondiabetic controls; inversely associated with blood glucose levels, HbA1c, BMI and insulin resistance; and positively associated with insulin secretion and insulin sensitivity (7,11,12).…”

Section: Introductionmentioning

confidence: 99%

Consistently Low Levels of Osteocalcin From Late Pregnancy to Postpartum Are Related to Postpartum Abnormal Glucose Metabolism in GDM Patients

Gong

Lai

et al. 2022

Front. Endocrinol.

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ObjectiveIncreasing evidence suggests that osteocalcin (OC), a marker of bone formation, plays an important role in glucose homoeostasis. Few studies have investigated the relationship between OC levels in gestational diabetes mellitus (GDM) patients and their postpartum glucose metabolism. This study evaluated the relationship between OC levels in late pregnancy, their longitudinal changes, and postpartum glucose metabolism among GDM patients.MeasuresSerum OC was measured in late pregnancy and the postpartum period for 721 GDM patients. All patients underwent a 75-g oral glucose tolerance test (OGTT) at 6–8 weeks postpartum. According to postpartum OGTT outcomes, patients were categorized into abnormal glucose metabolism (AGM) (n=255) and normal glucose tolerance (NGT) groups (n=466). Glucose metabolism-related indices were measured and calculated. Logistic regression analysis and linear mixed-effects model were used to assess the association between OC and postpartum AGM.ResultsIn late pregnancy, OC levels were lower in the AGM group than in the NGT group (13.93 ± 6.90 vs 15.33 ± 7.63 ng/ml, P=0.015). After delivery, OC levels increased in both groups. However, OC levels remained lower in the AGM group than in the NGT group (23.48 ± 7.84 vs 25.65 ± 8.37 ng/ml, P=0.001). Higher OC levels in late pregnancy were associated with decreased risk of progressing to postpartum AGM (OR:0.96, 95%CI:0.94–0.99). Linear mixed-effects analysis showed that postpartum AGM patients exhibited consistently lower OC levels than NGT group from late pregnancy to the postpartum period after adjustment for cofactors (β=-1.70, 95% CI: -2.78– -0.62). ConclusionsIn GDM patients, consistently low levels of OC from late pregnancy to postpartum were associated with increased postpartum AGM risk. The increase in serum OC may act as a protective factor to curb the progression of AGM at postpartum for GDM patients.

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“…The circulating level of OCN will increase with exercise. The level of OCN increases in high-intensity intermittent exercise ( Hiam et al, 2021 ). Changing regulation of glucose to mobilize bones, finally complete exercises.…”

Section: The Effect Of Mechanical Stimulation On Bone-derived Secreted Proteinmentioning

confidence: 99%

Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation

Zhang

Wang

et al. 2021

Front. Cell Dev. Biol.

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Bone serves as the support for body and provide attachment points for the muscles. The musculoskeletal system is the basis for the human body to complete exercise. Studies believe that bone is not only the basis for constructing structures, but also participates in the regulation of organs outside bone. The realization of this function is closely related to the protein secreted by bone. Whether bone can realize their positions in the human body is also related to their secretion. Bone-derived proteins provide a medium for the targeted regulation of bones on organs, making the role of bone in human body more profound and concrete. Mechanical stimulation effects the extra-skeletal organs by causing quantitative changes in bone-derived factors. When bone receives mechanical stimulation, the nichle of bone responds, and the secretion of various factors changes. However, whether the proteins secreted by bone can interfere with disease requires more research. In this review article, we will first introduce the important reasons and significance of the in-depth study on bone-derived secretory proteins, and summarize the locations, structures and functions of these proteins. These functions will not only focus on the bone metabolism process, but also be reflected in the cross-organ regulation. We specifically explain the role of typical bone-derived secretory factors such as osteocalcin (OCN), osteopontin (OPN), sclerostin (SOST) and fibroblast growth factor 23 (FGF23) in different organs and metabolic processes, then establishing the relationship between them and diseases. Finally, we will discuss whether exercise or mechanical stimulation can have a definite effect on bone-derived secretory factors. Understanding their important role in cross-organ regulation is of great significance for the treatment of diseases, especially for the elderly people with more than one basic disease.

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Osteocalcin and its forms respond similarly to exercise in males and females

Cited by 29 publications

References 87 publications

Investigation of the Relationship between the Mid_Thigh Adipose Tissue Distribution Measured by MRI and Serum Osteocalcin—A Sex-Based Approach

Investigation of the Relationship between the Mid_Thigh Adipose Tissue Distribution Measured by MRI and Serum Osteocalcin—A Sex-Based Approach

Consistently Low Levels of Osteocalcin From Late Pregnancy to Postpartum Are Related to Postpartum Abnormal Glucose Metabolism in GDM Patients

Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation

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