Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants

Habibović, Pamela; Gbureck, Uwe; Doillon, Charles J.; Bassett, D. C.; Blitterswijk, Clemens A. van; Barralet, Jake E.

doi:10.1016/j.biomaterials.2007.10.023

Cited by 315 publications

(252 citation statements)

References 38 publications

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“…Biomaterials have a range of properties, from osteoinductive and osteoconductive to immunomodulatory. Hydroxyapatite and calcium phosphate as well as their composites such as HA/poly(DL-lactic-co-glycolic acid) (PLGA), in the form of ceramics, cements and coatings have shown osteoinduction in animal models [60][61][62][63][64][65][66]. Various hybrid materials combined as co-polymers, polymer blends and polymer-ceramic blends have also shown efficacy [67][68][69][70][71][72][73].…”

Section: Biomaterialsmentioning

confidence: 99%

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić¹,

Dumić-Čule²,

Grčević³

et al. 2015

Bone

130

116

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Section: Biomaterialsmentioning

confidence: 99%

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić¹,

Dumić-Čule²,

Grčević³

et al. 2015

Bone

130

116

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“…While it is already deployed in practice [6,7,8], the current state of the technology still has many limitations. The price of commercial solutions, either the devices themselves or the custom made cartridges/bioinks, is still very high [9].…”

Section: Introductionmentioning

confidence: 99%

Development of an Extruder for Open Source 3D Bioprinting

Banović¹,

Vihar

2018

Journal of Open Hardware

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Bioprinting has gained significant traction in recent years due to it's implications for medicine and research with a growing spectrum of potential applications. The focus of this work lies on developing an open-source piston driven syringe extruder with thermo-regulation, that is compatible with various CNC systems but also provides broad control and functionality. The manuscript describes the construction and evaluation of the extruder, as well as extrusion parameters and tested fabrication capabilities.

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“…A computer can then reduce the model to slices or layers. The 3D objects are constructed layer-by-layer using rapid prototyping techniques such as fused deposition modeling [165,166], selective laser sintering [167][168][169], laser cladding [170], 3D printing [171][172][173][174][175][176][177][178][179][180], solid freeform fabrication [181][182][183][184][185] and/or stereo lithography [186][187][188][189]. Furthermore, a thermal printing process of melted calcium orthophosphates has been proposed as well [190].…”

Section: Forming and Shapingmentioning

confidence: 99%

“…Consequently, the osteoid is mineralized and the resulting new bone undergoes remodeling [606]. However, several reports have already shown osteoinductive properties of certain types of calcium orthophosphate bioceramics [177,459,504,[608][609][610][611][612][613][614][615][616][617][618][619][620][621]. Namely, bone formation was found to occur in dog muscle inside porous calcium orthophosphates with surface microporosity, while bone was not observed on the surface of dense bioceramics [616].…”

Section: Osteoinductionmentioning

confidence: 99%

“…The effect of a HA-based biomaterial on gene expression in osteoblast-like cells was reported as well [766]. To conclude this part, the excellent biocompatibility of calcium orthophosphate bioceramics, its possible osteoinductivity [177,459,504,[608][609][610][611][612][613][614][615][616][617][618][619][620][621] and a high affinity for drugs [767], proteins and cells [786] make them very functional for the tissue engineering applications. The feasible production of scaffolds with tailored structures and properties opens up a spectacular future for calcium orthophosphates [766][767][768][769][770][771][772][773][774].…”

Section: Bioceramic Scaffolds From Calcium Orthophosphatesmentioning

confidence: 99%

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Untitled

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants

Cited by 315 publications

References 38 publications

The rational use of animal models in the evaluation of novel bone regenerative therapies

The rational use of animal models in the evaluation of novel bone regenerative therapies

Development of an Extruder for Open Source 3D Bioprinting

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