Osteodistraction of mandibles with a small bone defect at the planned osteotomy site: A histological pilot study in dogs

Zandi, Mohammad; Dehghan, Arash; Saleh, Majid; Hoseini, Seyed Rohallah Seyed

doi:10.1016/j.jcms.2013.08.008

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…10 Compared with the conventional techniques for bone reconstruction, DO is a simpler procedure that has a shorter operation time, less blood loss, a shorter duration of hospitalisation, lower cost and risk of complications. 11-13 The DO procedure involves three sequential phases: latency; active distraction or lengthening; and consolidation. 14,15 It stimulates new bone formation through the controlled separation of two osteogenic fronts and also promotes the regeneration of the surrounding soft tissue.…”

Section: Introductionmentioning

confidence: 99%

Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis

Yang

Lin

Wang

et al. 2017

Bone & Joint Research

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ObjectivesDistraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results.MethodsWe hereby review the published literature on the use of MSCs in promoting bone consolidation during DO.ResultsStudies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods.ConclusionThe majority of studies reported that the transplantation of MSCs enhanced bone consolidation or formation in DO. Many questions relating to animal model, DO protocol and cell transplantation regime remain to be further investigated. Clinical trials are needed to test and confirm these findings from animal studies.Cite this article: Y. Yang, S. Lin, B. Wang, W. Gu, G. Li. Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies. Bone Joint Res 2017;6:385–390. DOI: 10.1302/2046-3758.66.BJR-2017-0023.

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