Osteodistrofia fibrosa em canino idoso secundário à doença renal crônica: Relato de caso

Freitas, Rosemar de Almeida; Porto, Aline Fernandes; Filho, Mário dos Santos; Paiva, Jonimar Pereira

doi:10.29374/2527-2179.bjvm013917

Cited by 4 publications

(17 citation statements)

References 11 publications

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“…Although increased jaw size is a common sign [1,9,11,18], this finding was not evidenced in the patient, indicating that is not Always observed in renal fibrous osteodystrophy [13]. In turn, bone flexibility in the maxillo-mandibular region is a common finding in dogs up to 4 years old, probably due to the still incomplete skeletal maturation [7], corroborating the age of [9].…”

Section: Discussionsupporting

confidence: 57%

“…This feature is mainly evidenced in the mandible and maxilla [1,9,13,18], as observed in the physical examination and radiographic images of the patient, and whose loss of bone support coincides with the literature [1,13,18]. The prognosis of fibrous osteodystrophy secondary to chronic kidney disease due to secondary hyperparathyroidism is unfavorable [1,9,13], leading to death or euthanasia request, as occurred in the animal. Although necropsy could not be performed on the patient, cases of this disorder in dogs often reveal gross anatomical appearance of the kidneys, with reduced size and nodular surface, and reduced cortex [18], similar to ultrasound findings, which the architecture tissue of the patient's kidneys were altered and with loss of cortico-medullary definition.…”

Section: Discussionmentioning

confidence: 78%

“…In turn, bone flexibility in the maxillo-mandibular region is a common finding in dogs up to 4 years old, probably due to the still incomplete skeletal maturation [7], corroborating the age of [9]. This feature is mainly evidenced in the mandible and maxilla [1,9,13,18], as observed in the physical examination and radiographic images of the patient, and whose loss of bone support coincides with the literature [1,13,18]. The prognosis of fibrous osteodystrophy secondary to chronic kidney disease due to secondary hyperparathyroidism is unfavorable [1,9,13], leading to death or euthanasia request, as occurred in the animal.…”

Section: Discussionmentioning

confidence: 83%

“…Early clinical signs of polyuria and polydipsia associated with gastrointestinal signs suggest a picture of chronic kidney disease [14,17], common signs in dogs with fibrous osteoarthritis, regardless of whether young [7] or elderly [1,9,13]. Although the development of chronic kidney disease is related to advanced age [2,17], the patient in question was young, and the possibility of an infectious cause due to visceral leishmaniasis was ruled out, because the patient was negative in the rapid serological test.…”

Section: Discussionmentioning

confidence: 99%

“…Aggravatingly, this scenario may imply the most dramatic consequence, which is renal fibrous osteodystrophy [7], characterized by intense proliferation of fibrous connective tissue [13], being uncommon in dogs [1,13,18]. Thus, this study aimed to report a case of fibrous osteodystrophy secondary to chronic kidney disease associated with hyperparathyroidism in a canine with "rubber jaw" facial deformity.…”

Section: Introductionmentioning

confidence: 99%

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Maxillomandibular Deformity in a Canine with Fibrous Osteodystrophy Secondary to Chronic Kidney Disease

Waller

Canuto

Costa

et al. 2019

Acta Scientiae. Vet.

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Background: Cases of renal fibrous osteodystrophy are usually associated with nutritional causes, which of renal causes are considered uncommon in dogs. This disorder is characterized by the intense proliferation of fibrous connective tissue in bones, impairing bone stiffness. The aim of this study was to report a case of fibrous osteodystrophy secondary to chronic kidney disease in a canine with a "rubber jaw" facial deformity. Case: A 4-year-old male unneutered mongrel dog weighing 5.2 kg had a history of apathy, progressive weight loss and vomiting for one month, and polyuria and polydipsia for more than three months. In addition, the owner complained about the deformed appearance in the muzzle region of the animal, which was evidenced flexibility of the same, with a displacement of the mandible and maxilla on physical examination, similar to the "rubber jaw". Blood tests revealed macrocytic anemia, elevated total plasma proteins, and lymphopenia-associated neutrophilia, as well as hyperphosphatemia (24 mg/ dL), uremia (283.6 mg/dL) and increased creatinine (8.6 mg/dL), ALT (143.2 UI/L) and alkaline phosphatase (3222.2 UI/L), while calcium (8.8 mg/dL) and albumin (1.9 g/dL) were decreased. A serological test for visceral leishmaniasis was also performed, which was negative. Abdominal ultrasound imaging revealed kidneys with alterations in tissue architecture, increased thickness and complete loss of cortico-medullary relationship, while the parathyroid gland was enlarged and spindle-shaped. Cranial radiography showed marked radiopacity of the bilateral maxillary bones, with destruction of the nasal, turbinate and frontal bones, as well as loosening of the teeth and destruction of the mandibular bone matrix, characterizing an aspect of "rubber jaw". Based on the history, history and evidence of azotemia, hyperphosphatemia and loss of facial bone density, the diagnosis of fibrous osteodystrophy secondary to chronic kidney disease associated with hyperparathyroidism was concluded. Discussion: The clinical and laboratory findings reported in the present study were similar to those described in dogs with renal fibrous osteodystrophy associated with hyperparathyroidism. In the presence of azotemia, the patient was in stage 4 of chronic kidney disease which, despite investigating the infectious etiology, which was negative, remained unknown. Along with chronic kidney disease, the observation of hyperphosphatemia associated with hypokalemia contributed to the clinical investigation, whose pathophysiological mechanisms of this disorder were discussed in this study. The organic alterations observed in the patient's imaging examination coincided with the pathophysiological processes of renal fibrous osteodystrophy. The findings of renal and parathyroid alterations on ultrasound, as well as the damage to the bone matrix, maxillomandibular deformity and loss of bone support evidenced on cranial radiography, led to the conclusion of the diagnosis of renal fibrous osteodystrophy secondary to hyperparathyroidism. Despite the ...

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maxillomandibular Deformity in a Canine with Fibrous Osteodystrophy Secondary to Chronic Kidney Disease

Waller

Canuto

Costa

et al. 2019

Acta Scientiae. Vet.

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>b<Plataforma de ensino em anatomia animal:>/b< conteúdos didáticos para o ambiente virtual de aprendizagem e impressão 3D como técnica anatômica

Massari¹

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Fibrous osteodystrophy due to secondary renal hyperparathyroidism in a senile dog

Rossi

Sousa

Rocha

et al. 2022

Arq. Bras. Med. Vet. Zootec.

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Renal hyperparathyroidism stands out among the complications of kidney disease in dogs due to phosphorus retention with a predisposition to hypocalcemia, parathyroid hormone stimulation with mobilization of calcium from the bones, characterizing fibrous osteodystrophy, unusual in the elderly. The objective was to report it in 12-year-old Labrador with polyuria, polydipsia, and emesis for five months due to maxillary and mandibular volume increase, followed by loosely fixed teeth, and facial deformity. Blood tests showed anemia, thrombocytosis, azotemia, hypoalbuminemia and hyperphosphatemia and urinalysis showed low density, glycosuria, proteinuria, and moderate caudate and transitional epithelial cells. Oral x-rays showed loss of dental bone support and decreased bone radiopacity. Chest radiographs showed decreased density in the ribs and costochondral junction; on the other hand, organs of the cardiorespiratory system showed no changes. The electrocardiogram and echocardiogram did not show impairment. Abdominal ultrasound revealed kidneys with asymmetry, increased echogenicity of the cortical and poorly preserved cortico-medullary definition. Oral histopathology showed intense fibroplasia associated with bone reabsorption. Support therapy was instituted, but the patient died ten days after consultation. Thus, although uncommon in the elderly, fibrous osteodystrophy should be investigated in dogs with advanced-stage chronic kidney disease and, even with conservative therapies, the prognosis is unfavorable.

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Osteodistrofia fibrosa em canino idoso secundário à doença renal crônica: Relato de caso

Cited by 4 publications

References 11 publications

Maxillomandibular Deformity in a Canine with Fibrous Osteodystrophy Secondary to Chronic Kidney Disease

Maxillomandibular Deformity in a Canine with Fibrous Osteodystrophy Secondary to Chronic Kidney Disease

>b<Plataforma de ensino em anatomia animal:>/b< conteúdos didáticos para o ambiente virtual de aprendizagem e impressão 3D como técnica anatômica

Fibrous osteodystrophy due to secondary renal hyperparathyroidism in a senile dog

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