Osteogenesis with coral is increased by BMP and BMC in a rat cranioplasty

Arnaud, Éric; Pollak, Cindy de; Meunier, Alain; Sedel, L.; Damien, Christopher; Petite, Hervé

doi:10.1016/s0142-9612(99)00090-3

Cited by 53 publications

(23 citation statements)

References 33 publications

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“…Enhanced resorption was noted with a BMP-like mixture in rabbits, 15 and recently, reduced resorption was observed with BMP mixed with NC granules in rat calvaria. 14 It has been suggested that the main factor in the resorption process is carbonic anhydrase, an enzyme abundant in osteoclasts. 35 TGF-␤ inhibits both the formation of osteoclast-like cells in long-term human marrow cultures 36 and osteoclast differentiation 37 and osteoclastic bone resorption in vitro.…”

Section: Discussionmentioning

confidence: 99%

Transforming growth factor β released from natural coral implant enhances bone growth at calvarium of mature rat

Vuola

Böhling

Göransson

et al. 2001

J. Biomed. Mater. Res.

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Earlier studies have shown that transforming growth factor beta (TGF-beta) has the capability of enhancing bone formation after a single application to an orthotopic site. We investigated whether 1, 5, or 25 microg of recombinant human TGF-beta1 added to porous natural coral (NC) blocks could promote bone ingrowth in a critical size defect (CSD) model in nongrowing rats. A 6-mm CSD in the parietal bone of Wistar rats was filled with NC disks, which were retrieved at 3 and 8 weeks. We prepared undecalcified sections for microscopy and histomorphometry to study bone formation in the implants. The differences in the means of the measured variables were compared with a one-way analysis of variance and Tukey's Student range test, and p values smaller than 0.05 were considered statistically significant. Bone formation was enhanced in all the TGF-beta1-treated implants at 8 weeks in comparison with the controls, but none of the implants showed complete bridging across the defect. The number of macrophages and giant cells was reduced in the TGF-beta1 implants, which showed less resorption and more intact structure than the coral controls. Void areas without any fibrous tissue ingrowth were found only in the TGF-beta1-treated implants, which may partly explain the reduced resorption. The data suggested that TGF-beta1 induced enhanced but limited bone formation in mature rats and prevented resorption of the coral calcium carbonate matrix, possibly by hindering reactive cell formation and fibrous tissue ingrowth.

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Section: Discussionmentioning

confidence: 99%

Transforming growth factor β released from natural coral implant enhances bone growth at calvarium of mature rat

Vuola

Böhling

Göransson

et al. 2001

J. Biomed. Mater. Res.

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“…[44][45][46][47][48][49][50][51][52] Combinations of coral graft, BMPs and osteoprogenitor cells have shown potent bone healing potential which was comparable to the autologous bone grafting. 44,45,46,48,49 The cellular component of the composite graft originate in the vast majority from bone marrow. However, osteogenically induced adipose tissue stem cells have been utilized with favorable results.…”

Section: Animal Studiesmentioning

confidence: 99%

Is there a role of coral bone substitutes in bone repair?

Pountos

Giannoudis

2016

Injury

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Xenogeneic bone graft materials are an alternative to autologous bone grafting. Among such implants, coralline-derived bone grafts substitutes have a long track record as safe, biocompatible and osteoconductive graft materials. In this review, we present the available literature surrounding their use with special focus on the commercially available graft materials. Corals thanks to their chemical and structural characteristics similar to those of the human cancellous bone have shown great potential but clinical data presented to date is ambiguous with both positive and negative outcomes reported.Correct formulation and design of the graft to ensure adequate osteo-activity and resorption appears intrinsic to a successful outcome.

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“…Calcium carbonates of biological origin (nacre and coral) and their derivatives have been used as biocompatible and bioactive bone substitutes in the form of powder, porous ceramic or associated with organic gels for more than 20 years [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

Combes

Bareille

Rey

2006

J Biomedical Materials Res

116

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The feasibility of making calcium carbonate-calcium phosphate (CaCO 3 -CaP) mixed cements, comprising at least 40 % (w/w) CaCO 3 in the dry powder ingredients, has been demonstrated.Several original cement compositions were obtained by mixing metastable crystalline calcium carbonate phases with metastable amorphous or crystalline calcium phosphate powders in aqueous medium. The cements set within at most 1 hour at 37°C in atmosphere saturated with water. The hardened cement is microporous and exhibits weak compressive strength. The setting reaction appeared to be essentially related to the formation of a highly carbonated nanocrystalline apatite phase by reaction of the mestastable CaP phase with part or almost all of the metastable CaCO 3 phase. The recrystallization of metastable CaP varieties led to a final cement consisting of a highly carbonated poorly crystalline apatite (PCA) analogous to bone mineral associated with various amounts of vaterite and/or aragonite. The presence of controlled amounts of CaCO 3 with a higher solubility than the apatite formed in the welldeveloped calcium phosphate cements might be of interest to increase resorption rates in biomedical cement and favor its replacement by bone tissue. Cytotoxicity testing revealed excellent cytocompatibility of CaCO 3 -CaP mixed cement compositions.

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Osteogenesis with coral is increased by BMP and BMC in a rat cranioplasty

Cited by 53 publications

References 33 publications

Transforming growth factor β released from natural coral implant enhances bone growth at calvarium of mature rat

Transforming growth factor β released from natural coral implant enhances bone growth at calvarium of mature rat

Is there a role of coral bone substitutes in bone repair?

Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction

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