Osteogenic differentiation of mesenchymal stem cells on random and aligned PAN/PPy nanofibrous scaffolds

Yardımcı, Atike Ince; Baskan, Oznur; Yılmaz, Selehattin; Meşe, Gülistan; Özçivici, Engin; Selamet, Yusuf

doi:10.1177/0885328219865068

Cited by 22 publications

(8 citation statements)

References 63 publications

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“…MSC differentiation into osteogenic tissue has been extensively investigated using scaffolds, such as Hap [51], nonwoven nano, and microfibrous scaffolds of polymers [52][53][54][55][56], and their composites. Factors affecting the osteogenic differentiation of MSCs are classified into two categories.…”

Section: Electrospun Silica Nonwoven Fabricsmentioning

confidence: 99%

Cell Scaffolds for Bone Tissue Engineering

Iijima

Otsuka

2020

Bioengineering

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Currently, well-known surgical procedures for bone defects are classified into four types: (1) autogenous bone graft transplantation, (2) allogeneic bone graft transplantation, (3) xenogeneic bone graft transplantation, and (4) artificial bone graft transplantation. However, they are often risky procedures and related to postoperative complications. As an alternative, tissue engineering to regenerate new bone often involves the use of mesenchymal stem cells (MSCs), derived from bone marrow, adipose tissues, and so on, which are cultured into three-dimensional (3D) scaffolds to regenerate bone tissue by osteoinductive signaling. In this manuscript, we provide an overview of recent treatment of bone defects and the studies on the creation of cell scaffolds for bone regeneration. Bone regeneration from bone marrow-derived mesenchymal stem cells using silica nonwoven fabric by the authors’ group were provided. Potential application and future direction of the present systems were also described.

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Section: Electrospun Silica Nonwoven Fabricsmentioning

confidence: 99%

Cell Scaffolds for Bone Tissue Engineering

Iijima

Otsuka

2020

Bioengineering

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“…Electrospun nanofibers (NFs) are important nanomaterials with their large high porosity, specific surface area, small pore size, and well-connected pore structure [2]. Some of the potential application areas of the electrospun NFs are filtration membranes [3], drug delivery [4], tissue engineering [5,6], catalysts [7], actuators [8], food packaging [9], etc.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and air permeability of electrospun PAN/PVDF nanofibrous membranes

Yardımcı¹,

Kayhan²,

Durmus³

et al. 2022

Res. Eng. Struct. Mater.

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Electrospun nanofibers present well-design membranes for filtration applications. In this study, the synthesis of polyacrylonitrile (PAN)/polyvinylidene fluoride (PVDF) bicomponent nanofibers was reported for air filtration application. Polymer concentration effect on the morphology of PAN/PVDF nanofibers was investigated and 10, 20, 30, and 40 wt% PVDF were examined. PVDF amount influences the morphology, diameter, and thermal stability of the fibers. Morphological results revealed that beadless PAN/PVDF nanofiber was obtained and the diameter of the PAN/PVDF nanofibers decreased with the increasing amount of PVDF. However, at 30 wt% beads formation on the fibers was begun to observe. Optimum conditions to obtain uniform and beadless PAN/PVDF nanofibers were determined as 20 wt% PVDF concentration. The air permeability tests of PAN/PVDF nanofibers containing 20 wt% PVDF indicated that these nanofibrous membranes are appropriate materials for air filtration applications.

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“…The electrospinning technique provides a convenient approach to producing continuous nano-scale fibers [9]. Electrospun nanofibers are important nanomaterials with their large high porosity, specific surface area, small pore size, and well-connected pore structure [10] and find use in many application areas; filtration membranes [11], drug delivery [12], tissue engineering [13,14], catalysts [15], actuators [16], food packaging [17], etc. Polyacrylonitrile (PAN) which is a synthetic polymer having a semi-crystalline structure, is thermally stable and degrades over 300 °C [18].…”

Section: Introductionmentioning

confidence: 99%

Polyacrylonitrile (Pan) Electrospun Nanofibers Coated 3d Printed Pla Materials With Different Infill Patterns and Their Tensile Properties

Yardımcı

2022

International Journal of 3D Printing Technologies and Digital Industry

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In this study, the mechanical properties of 3D printed PLA samples produced with FDM technology with five different infill patterns; trihexagon, triangle, line, gyroid, and grid, and these patterns were compared for their mechanical properties. In the second part of the study, PLA specimens with different infill patterns were covered with PAN nanofibers synthesized by the electrospinning method to enhance their PLA poor mechanical properties. In the tensile tests, among the infill patterns, gyroid showed the highest Young Modulus with 1108 MPa. SEM results showed that PAN electrospun nanofibers were beadless and ordered nanofibers with an average diameter of 165.7±33 nm. The results showed that after PAN nanofibers coating on PLA specimens, the mechanical properties of the samples for all infill patterns improved, and tensile strain values of all specimens increased. PAN nanofibers could significantly enhance the brittle behavior of 3D printed PLA materials.

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Osteogenic differentiation of mesenchymal stem cells on random and aligned PAN/PPy nanofibrous scaffolds

Cited by 22 publications

References 63 publications

Cell Scaffolds for Bone Tissue Engineering

Cell Scaffolds for Bone Tissue Engineering

Synthesis and air permeability of electrospun PAN/PVDF nanofibrous membranes

Polyacrylonitrile (Pan) Electrospun Nanofibers Coated 3d Printed Pla Materials With Different Infill Patterns and Their Tensile Properties

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