Osteogenic effect of low-intensity pulsed ultrasound on peri-implant bone: A systematic review and meta-analysis

Abstract

This study aimed to evaluate the effect of low-intensity pulsed ultrasound (LIPUS) on promoting osseointegration around dental implants. Study selection: A comprehensive search was performed on two databases, including MEDLINE (PubMed) and Web of Science to identify relevant studies published before June 1, 2022. Randomized controlled trials that met the inclusion criteria were selected for the study. The year of publication, study design, animal species, number of animals, number of implants, implant position, implant size, intervention, follow-up time, bone volume ratio (BV/TV), bone-implant contact ratio (BIC), and implant removal torque value (RTV) measurements, including mean and SD, were extracted. Results: Ten randomized trials were included in this meta-analysis. The results showed that LIPUS significantly promoted osteogenesis around dental implants. Furthermore, in animal models of pre-existing diseases such as osteoporosis and diabetes, LIPUS had the same effect. The included data were divided into subgroups to explore the effects of different follow-up time, acoustic intensities, and frequencies. Results showed that higher acoustic intensities and frequencies significantly improve the osteogenic effects of LIPUS. There was some degree of heterogeneity owing to bias in the included studies. More high-quality randomized controlled trials are necessary in the future. Conclusions: LIPUS can promote bone healing around dental implants and is an attractive option for edentulous patients, especially those with pre-existing diseases. Further clinical trials on the use of LIPUS in implant dentistry are warranted. Furthermore, future studies must pay more attention to acoustic intensity and frequency.

LIPUS can promote osteogenesis of hPDLCs and inhibit the periodontal inflammatory response via TLR5

“…LIPUS has been found to enhance bone healing surrounding dental implants (Wang et al, 2023), promote alveolar bone regeneration in periodontal bone injury models, increase osteogenic activity, inhibit osteoclast-mediated bone resorption (Wu et al, 2021), and regulate the interaction between osteoblasts and osteoclasts, thereby promoting the balance of alveolar bone remodeling (Zhou et al, 2023). Additionally, LIPUS exhibits preventive and reparative effects on root resorption caused by orthodontic treatment and can expedite tooth movement (Adly et al, 2023).…”

Novel Nonthermal Atmospheric Plasma Irradiation of Titanium Implants Promotes Osteogenic Effect in Osteoporotic Conditions

“…The primary method of physical treatment targeting implantation sites is low-intensity pulsed ultrasound (LIPUS), which can promote bone trabecular reconstruction around the implant area in the early stage. However, due to the long treatment cycle and considerable cost of the LIPUS, its utilization is significantly restricted . Recently, titanium implant surface modification has emerged as a chief method for promoting osseointegration, including surface bioactive substances loading, hydrophilization, and so on. − Titanium was discovered in 1790 and has been extensively used in biomedicine since the latter half of the first century.…”

“…However, due to the long treatment cycle and considerable cost of the LIPUS, its utilization is significantly restricted. 17 Recently, titanium implant surface modification has emerged as a chief method for promoting osseointegration, including surface bioactive substances loading, hydrophilization, and so on. 18−21 Titanium was discovered in 1790 and has been extensively used in biomedicine since the latter half of the first century.…”