Osteogenic growth peptide (OGP)-loaded amphiphilic peptide (NapFFY) supramolecular hydrogel promotes osteogenesis and bone tissue reconstruction

Zuo, Yi; Xiong, Qing; Li, Qiwen; Zhao, Bin; Xue, Fei; Shen, Luxuan; Li, Hanwen; Yuan, Quan; Cao, Shuqin

doi:10.1016/j.ijbiomac.2021.12.028

Cited by 19 publications

(9 citation statements)

References 30 publications

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“…This illustrated that the role of OGP peptides in osteogenesis could not be ignored, which has been mentioned in previous studies. [ 34 ] OGP peptide promotes the expression of osteogenic factors in BMSCs by regulating the BMP signaling pathway. [ 17a ] In addition, we believe that the regulation of osteogenic genes by AL‐PLGA NPs is related to AL.…”

Section: Resultsmentioning

confidence: 99%

A Bone Targeting Nanoparticle Loaded OGP to Restore Bone Homeostasis for Osteoporosis Therapy

et al. 2023

Adv Healthcare Materials

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Restoring bone homeostasis is the key to the treatment of osteoporosis. How to increase osteogenic ability or inhibit osteoclast activity has always been a topic of great concern. In recent years, short peptides with biological activity have received great attention in bone repair. However, the application of short peptides is still limited due to the lack of a stable and targeted delivery system. We designed poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles modified by alendronate (AL) to transport osteogenic peptides (OGP) (AL‐PLGA@P NPs). Benefiting from the high affinity of AL for hydroxyapatite, AL‐PLGA@P NPs have the ability to target bone. In this delivery system, OGP that promotes osteogenesis synergizes with AL, which inhibits osteoclasts, to regulate bone homeostasis, which gives them more advantages in the treatment of osteoporosis. Our data showed that nanoparticles could selectively deliver peptides to the bone surface without systemic toxicity. Moreover, nanoparticles could upregulate osteogenesis‐related factors (ALP, Runx‐2, BMP2) and downregulate osteoclast‐related factors (TRAP, CTSK) in vitro. With AL‐PLGA@P NPs, bone microarchitecture and bone mass were improved in ovariectomized osteoporosis rats. Therefore, this study proposes a novel osteoporosis‐based drug system that effectively improves bone density.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

A Bone Targeting Nanoparticle Loaded OGP to Restore Bone Homeostasis for Osteoporosis Therapy

et al. 2023

Adv Healthcare Materials

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“…[182] Zuo et al used a well-studied amphiphilic peptide, NapFFY (Nap-Phe-Phe-Tyr), to coassemble with osteogenic growth peptide (OGP) for enhanced bone defect regeneration. [183] In addition to biomolecules, hydrogels serve as suitable carriers for delivering stem cells such as bone mesenchymal stem cells (BMSCs), adipose-derived stem cells (ADSCs), and dental stem cells (DSCs) to a defect area while maintaining their bioactivity. [12,184] Lisignoli et al seeded BMSCs into an HA-based hydrogel scaffold, which was then transplanted into a rat model with large segmental radius defects, resulting in defect mineralization and healing.…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…used a well‐studied amphiphilic peptide, NapFFY (Nap‐Phe‐Phe‐Tyr), to coassemble with osteogenic growth peptide (OGP) for enhanced bone defect regeneration. [ 183 ]…”

Section: General Biomedical Applicationsmentioning

confidence: 99%

Hydrogels in Dental Medicine

Chen

Zhang

Peng

et al. 2023

Advanced Therapeutics

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Oral diseases are a prevalent global health problem that are primarily characterized by microbial infections, inflammation, and destruction of oral tissues. Maintaining good oral health is essential for a high quality of life, but the effective treatment of oral diseases and the regeneration of lost dental tissues remain challenging. Hydrogels have emerged as promising biomaterials in modern dental medicine. Their 3D network structures, high water content, good biocompatibility, and various bioactivities enable them to serve as drug delivery platforms, antimicrobial materials, tissue regeneration scaffolds, and biosensors. This review provides an overview of the formation mechanisms, structures, and functions of hydrogels, and highlights their latest applications in treating oral and maxillofacial diseases, such as periodontal diseases, caries, pulp diseases, oral cancer, and mucosal diseases.

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“…It has been shown that the introduction of the osteogenic grow factor (OGP) peptide, and bone morphogenetic protein 2 (BMP-2) signal peptide, induced the differentiation of the mesenchymal stem cells into osteoblasts and enhanced bone regeneration. 24,25 Moreover, the low cost of the peptides and the ability to easily design and decorate the building blocks make them good candidates to serve as scaffolds in tissue engineering applications. [26][27][28] The Fluorenylmethoxycarbonyl diphenylalanine (Fmoc-FF) dipeptide is a low molecular weight gelator that can form hydrogels composed of a fibrillary nanometric network.…”

Section: Introductionmentioning

confidence: 99%

Stabilizing gelatin-based bioinks under physiological conditions by incorporation of ethylene-glycol-conjugated Fmoc-FF peptides

et al. 2022

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Osteogenic growth peptide (OGP)-loaded amphiphilic peptide (NapFFY) supramolecular hydrogel promotes osteogenesis and bone tissue reconstruction

Cited by 19 publications

References 30 publications

A Bone Targeting Nanoparticle Loaded OGP to Restore Bone Homeostasis for Osteoporosis Therapy

A Bone Targeting Nanoparticle Loaded OGP to Restore Bone Homeostasis for Osteoporosis Therapy

Hydrogels in Dental Medicine

Stabilizing gelatin-based bioinks under physiological conditions by incorporation of ethylene-glycol-conjugated Fmoc-FF peptides

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