Osteogenic potential of a novel microarc oxidized coating formed on Ti6Al4V alloys

Wang, Yaping; Jin, Lihua; Zeng, Lilan; Xiang, Junhuai; Zhang, Shufang; Wang, Jun; Xiong, Fucheng; Li, Chenglin; Zhao, Ying; Zhang, Rongfa

doi:10.1016/j.apsusc.2017.03.191

Cited by 42 publications

(20 citation statements)

References 25 publications

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“…It has been reported that MAO treatment greatly promotes osteogenic differentiation at the initial stage of bone formation due to the morphology and crystalline phases of the MAO treated surfaces, leading to an excellent cytocompatibility in viability, adhesion, proliferation and differentiation of MC3T3‐E1 preosteoblast . As in accordance with the studies on the dense surfaces, bio‐functionalized highly porous samples exhibited well attached and spread cells (Figure ).…”

Section: Discussionsupporting

confidence: 80%

“…Additionally, it is possible by MAO to obtain the formation of TiO 2 in the form of anatase and rutile . Some authors had stated that TiO 2 with structures of anatase and rutile induced the apatite formation in vitro . Kunzler et al developed a surface modification process to develop roughness gradients ranging from 1.0 to 5.7 μm on Ti surfaces.…”

Section: Discussionmentioning

confidence: 99%

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Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

et al. 2018

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Highly porous Ti implant materials are being used in order to overcome the stress shielding effect on orthopedic implants. However, the lack of bioactivity on Ti surfaces is still a major concern regarding the osseointegration process. It is known that the rapid recruitment of osteoblasts in bone defects is an essential prerequisite for efficient bone repair. Conventionally, osteoblast recruitment to bone defects and subsequent bone repair has been achieved using growth factors. Thus, in this study highly porous Ti samples were processed by powder metallurgy using space holder technique followed by the bio-functionalization through microarc oxidation using a Ca- and P-rich electrolyte. The biological response in terms of early cell response, namely, adhesion, spreading, viability, and proliferation of the novel biofunctionalized highly porous Ti was carried out with NIH/3T3 fibroblasts and MC3T3-E1 preosteoblasts in terms of viability, adhesion, proliferation, and alkaline phosphatase activity. Results showed that bio-functionalization did not affect the cell viability. However, bio-functionalized highly porous Ti (22% porosity) enhanced the cell proliferation and activity. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

et al. 2018

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“…TiP 2 O 7 is deemed to have good bioactivity due to its hydrolysis into HPO 4 2− ions according to Equation (5) [ 30 ] Apatite is only precipitated on bony tissue under normal conditions because the energy barrier for apatite nucleation is very high and is lowered only at the bony tissue site [ 12 ]. Therefore, this regularly arranged rutile-type titania with nanoscale pores provided more chemically active sites due to larger specific surface area.…”

Section: Resultsmentioning

confidence: 99%

Effects of Pre-Treatments on Bioactivity of High-Purity Titanium

Wang

Lü

et al. 2018

Materials

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Titanium and its alloys are frequently employed in medical and dental clinics due to their good tissue compatibility, including commercially available pure Ti, Ti6A4V, or Ti-15Zr-4Ta-4Nb. Yet, they may behave very differently when in contact with our plasma because of their own chemical composition. The present study was designed to compare the in vitro behavior of highly pure Ti (>99.99%; hpTi) with those of the above titanium specimens when they were subjected to heating in air (HT), H2O2 and heating (CHT), and heating in air after forming grooves on the surface (GT). Since one of the measures of material-tissue compatibility has been in vitro apatite formation in artificial plasma, like simulated body fluid (SBF) of the Kokubo recipe, the apatite deposition in SBF on their surface and in their grooves were examined in terms of the X-ray diffraction, scanning electron microscopy, and energy dispersion X-ray analysis. The results showed that hpTi was as active in in vitro apatite deposition as the other reference titanium samples mentioned above. Moreover, GT specimens of hpTi induced apatite deposition on the platform of the grooves as well as in the grooves. Therefore, hpTi was concluded to have better activity, and to be clinically applicable.

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“…Under the instantaneous high temperature on the anode, phytic acid radicals adjacent to the anode are hydrolyzed into inorganic phosphates, as shown in Figure 8 . During MAO, the following reactions on the anode may take place [ 10 ]: Ti − 4e − = Ti 4+ H 2 O = 2H + + O 2− Ti 4+ + 2O 2− = TiO 2 H 3 PO 4 = 3H + + PO 4 3 − 3Zn 2+ + 2PO 4 3− = Zn 3 (PO 4 ) 2 …”

Section: Discussionmentioning

confidence: 99%

“…Therefore, inorganic phosphorus-containing electrolytes, for example, H 3 PO 4 , glycerophosphate disodium salt pentahydrate, NaH 2 PO 4 , and (NaPO 3 ) 6 are widely used in MAO on titanium alloys [ 5 , 6 , 7 , 8 , 9 ]. As a natural and nontoxic organic macromolecule, phytic acid, also known as inositol hexakisphosphate (C 6 H 6 (PO 4 ) 6 H 12 , as shown in Figure 1 ), is recently used as a novel phosphorus-containing electrolyte on titanium alloys and the fabricated MAO coatings show good biocompatibility [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Zinc and Phosphorus Elements Incorporated into Micro-Arc Oxidation Coatings Developed on Ti-6Al-4V Alloys

et al. 2018

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In order to clarify the mechanism that zinc and phosphorus elements entering the micro-arc oxidation (MAO) coatings developed on Ti-6Al-4V alloys, anodic coatings containing different zinc and phosphorus were fabricated using an orthogonal experiment of four factors with three levels in an electrolyte containing EDTA-ZnNa2, KOH, and phytic acid. Surface morphology, element composition, chemical state and phase structure of MAO coatings were characterized by scanning electron microscope (SEM), energy dispersive X-ray spectrometer (EDS), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). The concentrations of zinc and phosphorus in the electrolyte were analyzed by an inductively coupled plasma optical emission spectrometry (ICP-OES). The results show that zinc and phosphorus elements in MAO coatings exist in the form of Zn3(PO4)2. Phytic acid is the most important factor on both zinc and phosphorus contents of MAO coatings. With the increase of phytic acid concentration or the decrease of KOH concentration, the contents of zinc and phosphorus in MAO coatings present a similarly increasing tendency. Our results indicate that phosphorus takes part in coating formation mainly by diffusion, while zinc enters into MAO coatings with phosphorus from phytic acid.

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Osteogenic potential of a novel microarc oxidized coating formed on Ti6Al4V alloys

Cited by 42 publications

References 25 publications

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

Effects of Pre-Treatments on Bioactivity of High-Purity Titanium

Investigation of Zinc and Phosphorus Elements Incorporated into Micro-Arc Oxidation Coatings Developed on Ti-6Al-4V Alloys

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