Osteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration (Adv. Mater. 36/2022)

Zhang, Jin; Tong, Dongmei; Song, Honghai; Ruan, Renjie; Sun, Yun-Yu; Lin, Yandai; Wang, Jun; Hou, Linxi; Dai, Jiayong; Ding, Jianxun; Yang, Huanghao

doi:10.1002/adma.202270257

Cited by 45 publications

(45 citation statements)

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“…To probe the function of MCPC composites on osteogenic differentiation and mineralization, the cell proliferation and adhesion, the alkaline phosphatase (ALP) and Alizarin red S (ARS) staining, and the expression of osteogenic specific marker genes of BMSCs were evaluated. [ 44 ] We found that the MCPC composites significantly promoted the proliferation and viability of BMSCs (Figure S2, Supporting Information). The morphology and adhesion ability of BMSCs onto the surface of MCPC composites could be observed visibly by the SEM in Figure A.…”

Section: Resultsmentioning

confidence: 99%

“…[ 55 ] Studies have revealed that promoting angiogenesis‐dependent bone formation is beneficial to osteoporosis treatment. [ 26,44 ] Therefore, to improve the pathologic microenvironment of osteoporosis and mimic the porous structure for angiogenesis and vessel ingrowth, HMSNs/GM microspheres with unique cross‐linking gradients were homogeneously dispersed in the MCPC matrix. As feeding time progressed to 6 and 12 weeks, the rats were euthanatized and related tissue samples were collected and analyzed by µ‐CT to assess the situation of bone healing (Figure 7D).…”

Section: Resultsmentioning

confidence: 99%

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Multifunctional Scaffold for Osteoporotic Pathophysiological Microenvironment Improvement and Vascularized Bone Defect Regeneration

Kang

Zhuang

et al. 2023

Adv Healthcare Materials

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Osteoporosis is a degenerative bone disease resulting from bone homeostasis imbalance regulated by osteoblasts and osteoclasts. Treating osteoporotic bone defects tends to be more difficult due to suppressed osteogenic differentiation, hyperactive osteoclastogenesis, and impaired angiogenesis. Hence, a drug carrier system composed of gelatin-coated hollow mesoporous silica nanoparticles (HMSNs/GM) loaded with pro-osteogenic parathyroid (PTH) and anti-osteoclastogenic alendronate (ALN) is constructed and compounded into calcium magnesium phosphate cement (MCPC). The spatial-temporal release of ions and drugs, controllable degradation rate, and abundant pore structure of MCPC composites enhance osteoporotic bone regeneration in ovariectomized rats by accelerating vascularization, promoting osteogenic differentiation and mineralization, and inhibiting osteoclastogenesis and bone resorption. The MCPC/HMSNs@ALN-PTH/GM demonstrates a synergistic threefold effect on osteogenesis, osteoclastogenesis, and angiogenesis. It improves the osteoporotic pathophysiological microenvironment and promotes osteoporotic vascularized bone defect regeneration, holding huge potential for other functional biomaterials design and clinical management.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Multifunctional Scaffold for Osteoporotic Pathophysiological Microenvironment Improvement and Vascularized Bone Defect Regeneration

Kang

Zhuang

et al. 2023

Adv Healthcare Materials

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“…During the bone remodeling process, manipulating anti‐infection, immunoregulation, and angiogenesis are essential prerequisites for augmenting osteogenesis (Figure 9K). [ 45 ] As compared to surface modifications, we incorporated Mg and Cu elements into the Zn matrix to achieve bio‐multifunctions, which can maintain biological functionality throughout the healing process. At the early stage of implantation, the prevention of implant‐related infection can avoid excessive inflammatory responses and resultant macrophage migration, which deteriorate endothelial dysfunction, vascularization, and related osteogenesis.…”

Section: Discussionmentioning

confidence: 99%

Material–Structure–Function Integrated Additive Manufacturing of Degradable Metallic Bone Implants for Load‐Bearing Applications

Zhao

Sun

et al. 2023

Adv Funct Materials

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The integration of bio-adaptable performance, elaborate structure, and biological functionality for degradable bone implants is crucial in harnessing the body's regenerative potential to remold load-bearing bone defects. Herein, material-structure-function integrated additive manufacturing (MSFI-AM) is deployed to innovate novel zinc-based bone implants, namely Zn-Mg-Cu alloy. In situ alloying of AM and boundary engineering strategy yield prominent mechanical properties, and the degradation products enable a mechanical self-strengthened effect, thus coordinating mechanical degeneration and promoting mechanical adaptability. In addition, MSFI-oriented Zn alloy implants successfully manifest in situ multifunctions of augmenting osteogenesis, immunoregulation, angiogenesis, and anti-infective activity in vitro and expediting bone ingrowth and regeneration in vivo through the sustained release of divalent metal cations and triply periodic minimal surface (TPMS) structure construction. Overall, MSFI-AMed Zn alloy implants signify promising clinical translation prospects for load-bearing applications, and an integrated approach is proposed to endow degradable bone implants with boosted bio-adaptable performance and in situ bio-multifunctions.

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“…For this purpose, various demineralized bone matrix (DBM) hybrid scaffolds or DBM particles and nanocoatings have been studied, ,− since DBM alone can only function as a filling material instead of a bone graft. In the aspect of promoting bone regeneration, most tissue engineers are inclined to incorporate tissue-growth factors, such as VEGF and BMP-2, or stem cells into scaffolds. − …”

Section: Tissue Engineering For Bone Fixation and Bone Regenerationmentioning

confidence: 99%

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

et al. 2023

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Bone fractures have always been a burden to patients due to their common occurrence and severe complications. Traditionally, operative treatments have been widely used in the clinic for implanting, despite the fact that they can only achieve bone fixation with limited stability and pose no effect on promoting tissue growth. In addition, the nondegradable implants usually need a secondary surgery for implant removal, otherwise they may block the regeneration of bones resulting in bone nonunion. To overcome the low degradability of implants and avoid multiple surgeries, tissue engineers have investigated various biodegradable materials for bone regeneration, whereas the significance of stability of long-term bone fixation tends to be neglected during this process. Combining the traditional orthopedic implantation surgeries and emerging tissue engineering, we believe that both bone fixation and bone regeneration are indispensable factors for a successful bone repair. Herein, we define such a novel idea as bone regenerative fixation (BRF), which should be the main future development trend of biodegradable materials.

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Osteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration (Adv. Mater. 36/2022)

Cited by 45 publications

References 0 publications

Multifunctional Scaffold for Osteoporotic Pathophysiological Microenvironment Improvement and Vascularized Bone Defect Regeneration

Multifunctional Scaffold for Osteoporotic Pathophysiological Microenvironment Improvement and Vascularized Bone Defect Regeneration

Material–Structure–Function Integrated Additive Manufacturing of Degradable Metallic Bone Implants for Load‐Bearing Applications

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

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