Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts

Zupan, Janja; Jeras, Matjaž; Marc, Janja

doi:10.11613/bm.2013.007

Cited by 161 publications

(148 citation statements)

References 212 publications

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“…It also contributed to 3.27% (C group), 5.42% (AN group), and 8.92% (C + AN group) of OPG/sRANKL ratio variability. These results are suggestive of a relationship between TGF-β1 and OC, OPG/sRANKL ratio in our study subjects and seem to confirm the hypothesis generated from in vitro studies, namely that TGF-β1 might play a role in the regulation of bone remodelling in girls with AN with concurrent involvement of the RANKL/RANK/OPG system [2,4,6,8]. The concept of desynchronisation between bone metabolism and the RANKL/RANK/OPG system in girls with AN seems to be lent support by a negative and significant correlation between CTx and sRANKL observed along with a positive correlation between bone markers and the OPG/sRANKL ratio.…”

Section: Prace Oryginalnesupporting

confidence: 90%

“…Pomeroy et al [38] found significant elevation of TGF-β, while Corcos et al [39] found a significant decrease of TGF-β2, in young women with AN compared to the control participants. All these data [2,7,8,36], along with our previous results [25][26][27][28][29][30][31], indicate that the abnormal TGF-β concentrations in women with AN demonstrated by several authors [38,39] might promote the development of osteoporosis in these patients, possibly through OPG and/or RANKL. To the best of our knowledge, the relationship between potential changes in TGF-β1 concentrations and bone markers in girls with AN has not been studied so far.…”

Section: Prace Oryginalnesupporting

confidence: 61%

“…Considering the fact that TGF-β1, a ubiquitous growth factor, is not a pro-but an anti-inflammatory cytokine that controls both osteoblast and osteoclast differentiation, and therefore balances between bone formation and resorption [2,7,8], it might be expected that possible disturbances in its production could have some role in the mechanism leading to the development of osteoporosis in adolescents with AN. Raymond et al [37] investigated spontaneous or mitogen-induced secretion of TGF-β1 from peripheral blood mononuclear cells in patients with AN.…”

Section: Prace Oryginalnementioning

confidence: 99%

“…TGF-β1, TGF-β2, and TGF-β3; however, TGF-β1 constitutes the largest source of TGF-β in bone [1][2][3][4][5]. Numerous investigations, and especially in vitro studies, indicate that TGF-β1 may act as an important regulator of bone remodelling by influencing both bone formation and bone resorption as well as the production of certain pro-inflammatory cytokines [2,[5][6][7][8]. A role of TGF-β1 in coupling bone resorption with formation was also suggested [4].…”

Section: Introductionmentioning

confidence: 99%

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TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

Ostrowska

Ziora

Oświęcimska

et al. 2016

Endokrynologia Polska

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Introduction: Numerous investigations, and especially in vitro studies, indicate that TGF-β1 may act as an important regulator of bone remodelling. Thus, it could be expected that disturbances of this cytokine production observed by several researchers might play a role in the mechanism leading to the development of osteoporosis in girls with anorexia nervosa (AN). The aim of the study was to determine whether 1) girls with AN exhibited a relationship between TGF-β1 and bone metabolism (as assessed based on serum OC and CTx concentrations) and 2) whether OPG and sRANKL might modify the possible relationship between TGF-β1 and bone metabolism. Material and methods: Serum concentrations of TGF-β, OC, CTx, OPG, and its soluble ligand sRANKL were determined by ELISA in 60 girls with AN and in 20 healthy controls (C). All study participants were aged 13 to 17 years. Results: Body weight, BMI, BMI-SDS and the Cole index, serum TGF-β1, OC, CTx, and the OPG/sRANKL ratio were significantly reduced, while OPG and sRANKL levels were significantly increased, in girls with AN compared to healthy participants. BMI and the Cole index correlated negatively and significantly with serum CTx and OPG (AN group) or CTx only (groups C and C + AN). Girls with AN showed a positive and significant correlation between the Cole index and serum TGF-β1. The combination group (C + AN) showed a positive and significant correlation between BMI, the Cole index, and the OPG/sRANKL ratio and TGF-β1 concentration, while TGF-β1 correlated positively and significantly with OC concentrations and the OPG/sRANKL ratio. The Cole index and BMI were identified to be significant and independent predictors of CTx (C, AN, and C+AN groups) and OPG (AN group); the Cole index, BMI, and TGF-β1 independently predicted the OPG/sRANKL ratio (C, AN, and C + AN groups); TGF-β1 was found to be an independent predictor of OC (C + AN group). Conclusions: Changes in bone markers, OPG, and/or OPG/sRANKL ratio observed in girls with AN are associated with changes in serum TGF-β1 concentrations. TGF-β1 suppression in girls with AN might lead to disturbances in the relationship between bone metabolism and the OPG/sRANKL system, which, in turn, might compromise the mechanism compensating for bone remodelling disturbances. (Endokrynol Pol 2016; 67 (5): 493-500)

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Section: Prace Oryginalnesupporting

confidence: 90%

Section: Prace Oryginalnesupporting

confidence: 61%

Section: Prace Oryginalnementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

Ostrowska

Ziora

Oświęcimska

et al. 2016

Endokrynologia Polska

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“…It has been shown that even a small rise in the level of systemic inflammation can precipitate osteodestruction [2,21,62].…”

Section: Effect Of Arthritic Mediators On Osteoclast Progenitorsmentioning

confidence: 99%

Induction of osteoclast progenitors in inflammatory conditions: key to bone destruction in arthritis

Šućur

Katavić

Kelava

et al. 2014

International Orthopaedics (SICOT)

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The inflammatory milieu favors recruitment and activation of osteoclasts, and leads to bone destruction as a serious complication associated with arthritis and with other inflammatory processes.The frequency and activity of osteoclast progenitors (OCPs) correspond to arthritis severity, and may be used to monitor disease progression and bone resorption, indicating the need for detailed characterization of the discrete OCP subpopulations. Collectively, current studies suggest that the most potent murine bone marrow OCP population can be identified among lymphoid negative population within the immature myeloid lineage cells, as B220 -CD3 -CD11b -/lo CD115 + CD117 + CX3CR1 + and possibly also Ter119 -CD11c -CD135 lo Ly6C + RANK -. In the peripheral blood OCP population bears the monocytoid phenotype B220 -CD3 -NK1.1 -CD11b + Ly-6C hi CD115 + CX3CR1 + , presumably expressing RANK in committed OCPs. Much less is known about human OCPs and their regulation in arthritis, but the circulating OCP subset is, most probably, comprised among the lymphoid negative population (CD3 -CD19 -CD56 -), within immature monocyte subset (CD11b + CD14 + CD16 -), expressing receptors for M-CSF and RANKL (CD115 + RANK + ). Our preliminary data confirmed positive association between the proportion of peripheral blood OCPs, defined as CD3 -CD19 -CD56 -CD11b + CD14 + , and the disease activity score (DAS28) in the follow-up samples from patient with psoriatic arthritis receiving anti-TNF therapy. In addition, we reviewed cytokines and chemokines which, directly or indirectly, activate OCPs and enhance their differentiation potential, thus mediating osteoresorption.Control of the activity and migratory behavior of OCPs as well as the identification of crucial bone/joint chemotactic mediators represent promising therapeutic targets in arthritis.Keyword: osteoclast progenitors, arthritis, inflammation, cytokines, chemokines, osteoresorption 3 Inflammation induced bone lossBone is a highly dynamic tissue important for its mechanical and metabolic functions, and characterized by rapid response to numerous physical, endocrine and paracrine stimuli in physiological and pathological conditions. Among others signals, osteoresorptive mediators (such as interleukin (IL)-1, IL-6, IL-15, IL-17, IL, 21, IL-33, tumor necrosis factor (TNF)-α and receptor activator of nuclear factor-κB ligand (RANKL), CCL2, CXCL12) produced by inflammatory/immune cells create conditions that promote maturation and function of osteoclasts [1][2][3][4]. Bone resorption and osteolysis are the prominent features and causes of substantial morbidity in inflammatory processes associated with arthritis as well as with localized bacterial infections of bone and adjacent tissues, peri-prosthetic loosening, vasculitis, connective tissue diseases, chronic viral infections and inflammatory bowel diseases [5][6][7][8]. Bone resorption in arthritisInflammatory arthritides comprise a heterogeneous group of joint disorders that are characterized by chronic inflammatory response as we...

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A Truncated IL‐17RC Peptide Ameliorates Synovitis and Bone Destruction of Arthritic Mice

Tong

Mei

et al. 2016

Adv Healthcare Materials

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Peptide-based therapy, such as modified peptides, has attracted increased attention. IL-17 is a promising therapeutic target for autoimmune diseases, and levels of circulating bioactive IL-17 are associated with rheumatoid arthritis severity. In this study, a modified truncated IL-17RC is generated to ameliorate inflammation and bone destruction in arthritis. The truncated IL-17RC binds to both IL-17A and IL-17F with higher binding capacity compared to nonmodified IL-17RC. In addition, the truncated IL-17RC reduces the secretion of inflammatory and osteoclastogenic factors induced by IL-17A/F in vitro. Moreover, the administration of truncated IL-17RC dramatically improves symptoms of inflammation and inhibited bone destruction in collagen-induced arthritis mice. Collectively, these data demonstrate that modified truncated IL-17RC peptide may be a more effective treatment strategy in the simultaneous inhibition of both IL-17A and IL-17F signaling, whereas the existing agents neutralize IL-17A or IL-17F alone. These suggest that the truncated IL-17RC may be a potential candidate in the treatment of inflammatory associated bone diseases.

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Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts

Cited by 161 publications

References 212 publications

TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

Induction of osteoclast progenitors in inflammatory conditions: key to bone destruction in arthritis

A Truncated IL‐17RC Peptide Ameliorates Synovitis and Bone Destruction of Arthritic Mice

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