Osteoimmunology: cytokines and the skeletal system

Lee, Seoung‐Hoon; Kim, Taesoo; Choi, Yongwon; Lorenzo, Joseph

doi:10.5483/bmbrep.2008.41.7.495

Cited by 96 publications

(87 citation statements)

References 189 publications

(225 reference statements)

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“…RANKL is the key osteoclastogenic molecule expressed by osteoclastogenesis-supporting cells like activated CD4 + T cells, osteoblasts, and synoviocytes (28,29), and it binds to its single receptor RANK, and thereby mediates osteoclastogenesis that leads to bone destruction. To examine the effect of ATRA on osteoclast formation, we performed TRAP staining on the tissue sections from the joints from mice treated with ATRA or vehicle.…”

Section: Atra Inhibits Osteoclastogenesis In Cia Micementioning

confidence: 99%

Retinoic Acid Attenuates Rheumatoid Inflammation in Mice

Kwok

Park

Cho

et al. 2012

The Journal of Immunology

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Retinoic acid is the active vitamin A derivative and is well-known to have diverse immunomodulatory actions. In this study, we investigated the impact of all-trans retinoic acid (ATRA), a biologic key metabolite of vitamin A, on the development of arthritis and the pathophysiologic mechanisms by which ATRA might have antiarthritic effects in animal model of rheumatoid arthritis (RA; collagen-induced arthritis [CIA] in DBA/1J mice). We showed that treatment with ATRA markedly suppressed the clinical and histologic signs of arthritis in the CIA mice. It reduced the expression of IL-17 in the arthritic joints. Interestingly, Foxp3+ regulatory T cells were markedly increased and IL-17–producing CD4+ T cells (Th17 cells) were decreased in the spleens of ATRA-treated mice. In vitro treatment with ATRA induced the expression of Foxp3 and repressed the IL-17 expression in the CD4+ T cells in mice. ATRA suppressed the production of total IgG and IgG2a in splenocytes that were stimulated by LPS. It also reduced serum levels of total IgG and IgG2 anti-collagen Abs and germinal center formation in CIA mice. In addition, the ATRA-treated mice showed decreased osteoclast formation in arthritic joints. Moreover, ATRA downregulated the expression of receptor activator of NF-κB ligand, the leading player of osteoclastogenesis, in the CD4+ T cells and fibroblast-like synoviocytes from patients with RA. Furthermore, ATRA prevented both human monocytes and mice bone marrow-derived monocytes/macrophage cells from differentiating into osteoclasts. These data suggest ATRA might be an effective treatment modality for RA patients.

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Section: Atra Inhibits Osteoclastogenesis In Cia Micementioning

confidence: 99%

Retinoic Acid Attenuates Rheumatoid Inflammation in Mice

Kwok

Park

Cho

et al. 2012

The Journal of Immunology

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“…The increased recognition of the interactions between the cells of the immune and skeletal system has led to the seeking of a variety of regulatory molecules that play a role in the progression of periodontal disease [25][26][27]. In previous studies, the bestknown markers of the bone turnover have been widely investigated in GCF samples of patients with different periodontal diseases and implicated to be associated with the progression of periodontal diseases [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

et al. 2011

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Abstract. Aim:The aim of the present study was to investigate gingival crevicular fluid (GCF) calprotectin, osteocalcin and cross-linked N-terminal telopeptide (NTx) levels in health along with different periodontal diseases. Material and methods: Twenty chronic periodontitis (CP), 20 generalized aggressive periodontitis (G-AgP), 20 gingivitis and 20 healthy subjects were included. Probing depth, clinical attachment level, plaque index and papillary bleeding index was recorded. GCF calprotectin, osteocalcin and NTx levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: CP, G-AgP and gingivitis groups had higher GCF calprotectin total amount compared to healthy subjects (p < 0.008). CP and G-AgP groups had similar, but higher levels compared to gingivitis groups (p < 0.008). CP and G-AgP groups had lower GCF osteocalcin total amount compared to gingivitis and healthy groups (p < 0.008). CP group had higher GCF NTx but lower osteocalcin total amount and osteocalcin/NTx ratio than the G-AgP group (p < 0.008). Conclusions: Our results suggest that elevated GCF calprotectin levels play a role as a reliable inflammatory marker in the pathogenesis of periodontal disease. Fluctuating GCF levels of osteocalcin and NTx might point out to the abnormal bone turnover in periodontitis. Our data document for the first time the role of NTx in the pathogenesis of different periodontal diseases.

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“…microenvironment of inflamed RA joints, local production of proinflammatory cytokines (interleukin-1 [IL-1], tumor necrosis factor ␣ [TNF␣], IL-6, and IL-17) as well as RANKL provided by activated CD4ϩ T cells and synoviocytes leads to stimulation of osteoclastogenesis and bone destruction (8,9).…”

mentioning

confidence: 99%

Interleukin‐21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen‐induced arthritis

Kwok

Cho

Park

et al. 2012

Arthritis & Rheumatism

106

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Objective. Bone destruction is a critical pathology involved in the functional disability caused by rheumatoid arthritis (RA). Osteoclasts, which are specialized bone-resorbing cells regulated by cytokines such as RANKL, are implicated in bone destruction in RA. The aim of this study was to determine whether interleukin-21 (IL-21), a potent immunomodulatory 4-␣-helical bundle type 1 cytokine, has osteoclastogenic activity in patients with RA and in mice with collageninduced arthritis (CIA).Methods. The expression of IL-21 in synovial tissue was examined using immunohistochemistry. The concentrations of IL-21 in serum and synovial fluid were determined by enzyme-linked immunosorbent assay.

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Osteoimmunology: cytokines and the skeletal system

Cited by 96 publications

References 189 publications

Retinoic Acid Attenuates Rheumatoid Inflammation in Mice

Retinoic Acid Attenuates Rheumatoid Inflammation in Mice

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

Interleukin‐21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen‐induced arthritis

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