Osteoimmunomodulation mediating improved osteointegration by OGP-loaded cobalt-metal organic framework on titanium implants with antibacterial property

Tao, Bailong; Lin, Changjian; Yuan, Zhangfu; Chen, Maowen; Xu, Ke; Li, Kai; Guo, Ai; Cai, Kaiyong; Chen, Lixue

doi:10.1016/j.cej.2021.130176

Cited by 57 publications

(41 citation statements)

References 56 publications

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“…[37] It should also be noted that LDH after calcination has elevated pH, which may also contribute to its antimicrobial property. [38][39][40] However, as we showed in Figure S9 (Supporting Information), only calcined V-LDH array kills bacteria, while randomly coated calcined LDH surface does not have antimicrobial properties in our testing conditions. In addition, although the as-prepared (uncalcined) V-LDH did not show antimicrobial properties, it became antimicrobial after surface modification and transformation to super-hydrophilicity.…”

Section: −mentioning

confidence: 67%

Surface Antimicrobial Treatment by Biocompatible, Vertically Aligned Layered Double Hydroxide Array

Gao

et al. 2022

Adv Materials Inter

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TiO 2 , [6][7][8] and others [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] have been prepared and reported to have structurebased antibacterial properties. However, most of the methods used for fabricating surface nanopatterns require special equipment [3,5,18] and expensive starting materials, [3][4][5] and are only applicable to certain substrates. [3][4][6][7][8]19,24] It would be desirable to have a simple and scalable method for creating biocidal nanostructures on commonly used substrates for practical applications. [9,20] There is also an urgent need for biocompatible nanostructured surface coating technology for biomedical applications. Layered double hydroxides (LDHs) or anionic clays are wellstudied biocompatible materials that have attracted our attention. LDH itself is made from common elements, and it exists in nature (hydrotalcite) and are nontoxic. [25] They have a gen-, where M 2+ = Mg, Zn, Cu, Ni or Co, M 3+ = Al, Fe or Cr, and X n− = intercalating anion. M 2+ to M 3+ ratio is between 1 and 5. [26] Herein, we report a method of growing vertically aligned Mg-Al-LDH on various substrates. The as-prepared vertically aligned LDH (V-LDH) array showed very weak antibacterial properties against E. coli. However, after further modification, it demonstrated greatly enhanced antibacterial properties against Gram negative bacteria, Gram positive bacteria and fungi. The relationships between the antimicrobial properties and the surface sharpness, surface potential and hydrophilicity were investigated. We found that hydrophilicity has the greatest influence to the antibacterial properties of V-LDH. The inherent antibacterial property, intercalation capability and facile synthesis of V-LDH provide the potential for broad applications of this new antimicrobial material.

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Section: −mentioning

confidence: 67%

Surface Antimicrobial Treatment by Biocompatible, Vertically Aligned Layered Double Hydroxide Array

Gao

et al. 2022

Adv Materials Inter

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“…This study suggested that the synergistic antimicrobial and bone immunomodulatory effects of TNT-ZIF-67@OGP open up a promising strategy for bone regeneration, particularly for the treatment of infected bone defects in orthopaedic implants. 118 Post-operative orthopaedic infections, particularly prosthetic joint infections (PJI), remain a major problem in orthopaedics. Iodine is an effective broad-spectrum antimicrobial disinfectant with no risk of drug resistance for clinical use.…”

Section: Preparation Of Antibacterial Coatings On Biomaterials Surfacesmentioning

confidence: 99%

“…Some selected representative examples for bone therapy are Uio-66–NH 2 , 60 Sr/PTA–MOF, 61 BT–isMOF, 45 MTX–TA/Fe 3+ @HA MOF, 66 V-RZCD, 38 and ALN–HA–ZIF-8@Sap. 49 For bone repair, we selected Zr–MOFs, 78 SF–DEX@ZIF8–Ti, 73 bio-MOF-1, 123 IL4–MOF@CaP, 107 TNT–ZIF-67@OGP 118 and DEX@Zn–Mg/MOF74. 85 As can be seen from Fig.…”

Section: Introductionmentioning

confidence: 99%

Current status and prospects of metal–organic frameworks for bone therapy and bone repair

et al. 2022

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“…It is worth noting that some researchers have achieved antibacterial and osseointegration by modulating the microenvironment around the implant. Tao et al prepared a multifunctional hybrid coating through depositing the zeolitic imidazolate frameworks-67 (ZIF-67) and an osteogenic growth peptide (OGP) on nanotubes ( Tao et al, 2021 ). Under the acidic environment, the coating gradually decomposed, releasing cobalt ions and forming an alkaline microenvironment to kill bacteria.…”

Section: Prevention Of Aseptic Implant Looseningmentioning

confidence: 99%

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

et al. 2021

Front. Bioeng. Biotechnol.

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Titanium and its alloys are dominant material for orthopedic/dental implants due to their stable chemical properties and good biocompatibility. However, aseptic loosening and peri-implant infection remain problems that may lead to implant removal eventually. The ideal orthopedic implant should possess both osteogenic and antibacterial properties and do proper assistance to in situ inflammatory cells for anti-microbe and tissue repair. Recent advances in surface modification have provided various strategies to procure the harmonious relationship between implant and its microenvironment. In this review, we provide an overview of the latest strategies to endow titanium implants with bio-function and anti-infection properties. We state the methods they use to preparing these efficient surfaces and offer further insight into the interaction between these devices and the local biological environment. Finally, we discuss the unmet needs and current challenges in the development of ideal materials for bone implantation.

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Osteoimmunomodulation mediating improved osteointegration by OGP-loaded cobalt-metal organic framework on titanium implants with antibacterial property

Cited by 57 publications

References 56 publications

Surface Antimicrobial Treatment by Biocompatible, Vertically Aligned Layered Double Hydroxide Array

Surface Antimicrobial Treatment by Biocompatible, Vertically Aligned Layered Double Hydroxide Array

Current status and prospects of metal–organic frameworks for bone therapy and bone repair

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

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