2020
DOI: 10.1093/rb/rbaa006
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Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration

Abstract: Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune responses. Traditional designing principles have been always aimed at minimizing the immune reactions by fabricating inert biomaterials. However, clinical evidence revealed that those methods still have limitations and many of which were only feasible in the laboratory. Currently, osteoimmunology, the very pioneering concept is drawing more and more attention—it does not simply regard the immune response as an… Show more

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Cited by 131 publications
(124 citation statements)
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“…Biomaterials applied in bone tissue engineering and regenerative medicine are usually categorized into polymeric, ceramic, metallic, and composite materials [15,16]. The most often used metallic biomaterials are titanium (Ti) and its alloys (e.g., Ti-6Al-4V, Ti-6Al-7Nb, Ti-6Al-2Nb-1Ta-0.8Mo, Ti-15Mo-5Zr-3Al) [17,18], stainless steel, cobalt (Co) and its alloys [15,18], magnesium (Mg) and its alloys, nickel-titanium alloy (Nitinol), tantalum (Ta) [16]. Metallic biomaterials have been commonly used as bone implants due to their corrosion resistance, fatigue strength, high ultimate tensile strength, toughness, durability, and biocompatibility [19,20].…”
Section: Bone Regenerative Medicinementioning
confidence: 99%
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“…Biomaterials applied in bone tissue engineering and regenerative medicine are usually categorized into polymeric, ceramic, metallic, and composite materials [15,16]. The most often used metallic biomaterials are titanium (Ti) and its alloys (e.g., Ti-6Al-4V, Ti-6Al-7Nb, Ti-6Al-2Nb-1Ta-0.8Mo, Ti-15Mo-5Zr-3Al) [17,18], stainless steel, cobalt (Co) and its alloys [15,18], magnesium (Mg) and its alloys, nickel-titanium alloy (Nitinol), tantalum (Ta) [16]. Metallic biomaterials have been commonly used as bone implants due to their corrosion resistance, fatigue strength, high ultimate tensile strength, toughness, durability, and biocompatibility [19,20].…”
Section: Bone Regenerative Medicinementioning
confidence: 99%
“…The organic part of biomaterial provides biomaterial flexibility and improves its biocompatibility [21][22][23], whereas the inorganic part provides load-bearing strength and stiffness [22]. In organic-inorganic composites, the organic matrix may be composed of natural polymers (e.g., chitosan, collagen, hyaluronic acid, fibrin, silk fibroin, alginate, amylopectin, carrageenan, agar, dextran, xanthan gum, pullulan) [15,[23][24][25][26] and/or synthetic polymers (e.g., polylactic acid (PLA), polycaprolactone (PCL), poly(glycolic acid) (PGA), polyanhydride, polyphosphazene, polyether ether ketone (PEEK), polypropylene fumarate (PPF)) [27], whereas the inorganic part may be made of metal alloys [16] and ceramics, such as hydroxyapatite (HA), calcium phosphate bone cements (CPS), α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), Bioglass (BG), glass-ceramics, as well as carbon nanotubes [15,24,27,28].…”
Section: Bone Regenerative Medicinementioning
confidence: 99%
“…As a result of prolonged inflammation, the biomaterial becomes encapsulated by a dense fibrotic tissue that separates it from the surrounding environment, leading to the failure of osseointegration and implantation. Thus, it is a host immune response that plays a pivotal role in the success of biomaterial implantation [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…Importantly, each phenotype exerts a different influence on the bone healing process after biomaterial implantation [ 5 ]. M1 macrophages may be identified by the secretion of proinflammatory factors, such as interleukin 1 beta (IL-1β), IL-6, IL-12, IL-23, tumor necrosis factor-alpha (TNF-α) as well as by the production of reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) [ 2 , 5 ]. Secreted by M1 cells, proinflammatory factors promote the development of Th1 lymphocytes and induce inflammation [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
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