Osteoinduction by calcium phosphate biomaterials

Abstract

Different materials were implanted in muscles of dogs to study the osteoinduction of calcium phosphate biomaterials. Bone formation was only seen in calcium phosphate biomaterials with micropores, and could be found in hydroxyapatite (HA) ceramic, tricalcium phosphate/hydroxyapatite ceramic (BCP), beta-TCP ceramic and calcium phosphate cement. The osteoinductive potential was different in different materials. The results indicate that osteoinduction can be a property of calcium phosphate biomaterials when they exhibit specific chemical and structural characteristics.

Osteoinduction by Ca-P biomaterials implanted into the muscles of mice

“…Since then, generous attention was paid to these kinds of biomaterials, such as synthetic hydroxyapatite ceramics (HA), porous biphasic calcium phosphate ceramics (BCP), tricalcium phosphate ceramics (TCP), calcium pyrophosphate ceramics, and coralderived hydroxyapatite. These ceramic materials have been shown to have intrinsic osteoinduction (Ducheyne and Cuckler, 1992;Toth et al, 1993;Yang et al, 1997;Yuan et al, 1998a;1998b;Nihouannen et al, 2005;Ye et al, 2007;Fellah et al, 2008). However, the main evidence of bone formation in these biomaterials was based on histological analysis and there were few reports focusing on the molecular mechanism.…”

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

“…The ceramic may also potentiate the activity of BMPs by binding the protein and presenting it to target cells. Former studies have already described an upregulation of BMPs by CaP bone grafts [97]. BMP-2 has been detected immunohistochemically in the host region around the grafted particles during early healing of a nanostructured sHA [60], indicating an absorption of these factors or activating endogenous BMP from the environment.…”

Fabrication and characterization of 3D complex hydroxyapatite scaffolds with hierarchical porosity of different features for optimal bioactive performance

“…In general, the nanoporosity in scaffolds could significantly promote osteoinductivity during bone tissue engineering by enhancing osteogenic differentiation [13,14], as many natural tissues like bone can be regarded as materials with some nanostructures. It was also found that both macro and micro porosity could influence osteoinductive activity to certain extent [10,11]. Particularly, the microporosity in the scaffolds is able to make substantial contribution to bone regeneration [15,16].…”

“…Owing to its similarity to the natural bones in chemical composition, HA (hydroxyapatite, Ca 10 [PO 4 ] 6 [OH] 2 ) has become an excellent biomaterial as substitutes of natural bones [3][4][5][6]. However, the uses of HA for bone regenesis have encountered a number of technical challenges, including its resistance to biodegradation in vivo [5], low fracture toughness, and high crystallinity [3].…”

“…The importance of porosity and pore structures on osteogenesis had been extensively investigated [10][11][12]. In general, the nanoporosity in scaffolds could significantly promote osteoinductivity during bone tissue engineering by enhancing osteogenic differentiation [13,14], as many natural tissues like bone can be regarded as materials with some nanostructures.…”