Osteointegration in Cranial Bone Reconstruction: A Goal to                     Achieve

Sprio, Simone; Fricia, Marco; Maddalena, G.; Nataloni, Angelo; Tampieri, Anna

doi:10.5301/jabfm.5000293

Cited by 20 publications

(15 citation statements)

References 36 publications

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“…Osteogenesis occurs most frequently through osteoconductivity mechanism. This is a three-dimensional process in which the biomaterial for augmentation acts as a matrix for the capillary proliferation, and the migration of proosteoblasts forms the adjacent tissue [ 17 , 18 ]. Osteoconductive materials cannot be used in the reconstruction of large bone defects, since bone formation is limited by the distance on which the replacement material is applied [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study

Anghelescu

Neculae

Dincă

et al. 2018

Journal of Immunology Research

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Introduction The clinical use of bioactive materials for bone augmentation has remained a challenge because of predictability and effectiveness concerns, as well as increased costs. The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae. There is a lack of in vivo studies of inflammatory-driven angiogenesis in bone engineering using various grafts. Methods The study was performed in animal experimental model on the standardized monocortical defects in the tibia of 20 New Zealand rabbits. The defects were augmented with three types of bone substituents. The used bone substituents were beta-tricalcium phosphate, bovine hydroxyapatite, and bioactive glasses. After a period of 6 months, bone fragments were harvested for histopathologic examination. Endothelial cell analysis was done by analysing vascularization with PECAM/CD31 and VEGF and fibrosis with collagen IV, laminin, and osteonectin stains. Statistical analysis was realized by descriptive analysis which was completed with the kurtosis and skewness as well as the Kruskal-Wallis and Mann-Whitney statistical tests. Results The discoveries show that the amount of bone that is formed around beta-tricalcium phosphate and bovine hydroxyapatite is clearly superior to the bioactive glasses. Both the lumen diameter and the number of vessels were slightly increased in favor of beta-tricalcium phosphate. Conclusion We can conclude that bone substitutes as bovine bone and beta-tricalcium phosphate have significant increased angiogenesis (and subsequent improved osteogenesis) compared to the bioactive glass. In our study, significant angiogenesis is linked with a greater tissue formation, indicating that in bone engineering with the allografts we used, inflammation has more benefic effects, the catabolic action being exceeded by the tissue formation.

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Section: Discussionmentioning

confidence: 99%

Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study

Anghelescu

Neculae

Dincă

et al. 2018

Journal of Immunology Research

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“…The bioactivity and effective osteointegration of a bone scaffold are key aspects to trigger and sustain bone regeneration in critical size defects [51]. In this respect, the approach presented in this work enabled the preparation of Sr-substituted HA cements with controlled and biomimetic composition, with defined strontium content replacing calcium in the lattice of HA, associated to excellent injectability, cohesion, and stable compressive strength enabling mechanical loading.…”

Section: Discussionmentioning

confidence: 99%

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

et al. 2016

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The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.

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“…An interesting alternative is in the use of synthetic porous HA ceramic that, due to its good bioactivity deriving from biomimetic composition, can stimulate new bone formation and tight integration of bone to the prosthesis, with recovery of the original biomechanical performance [34,35]. Despite the advantages, HA is reported to have the tendency to fragmentation due to its brittle character, typical of ceramic materials [28], which do not allow its use for load-bearing bone (e.g., femur, tibia, and metatarsus) reconstruction.…”

Section: Porous Hydroxyapatite Scaffolds For Bone Regenerationmentioning

confidence: 99%

Nature-Inspired Processes and Structures: New Paradigms to Develop Highly Bioactive Devices for Hard Tissue Regeneration

Preti¹,

Lambiase²,

Campodoni³

et al. 2019

Bio-Inspired Technology [Working Title]

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Material scientists are increasingly looking to natural structures as inspiration for new-generation functional devices. Particularly in the medical field, the need to regenerate tissue defects claims, since decades, biomaterials with the ability to instruct cells toward formation and organization of new tissue. It is today increasingly accepted that biomimetics is a leading concept for biomaterials development. In fact, there is increasing evidence that the use of biomedical devices showing substantial mimicry of the composition and multi-scale structure of target native tissues have enhanced regenerative ability. As a relevant example, biomimetic materials have high potential to solve degenerative diseases affecting the musculoskeletal system, namely, bone, cartilage and articular tissues, which is of pivotal importance for most of human abilities, such as walking, running, manipulating, and chewing. In this respect, the adoption of nature-inspired processes and structures is an emerging fabrication concept, uniquely able to provide biomaterials with superior biological performance. The chapter will give an overview of the most recent results obtained in the field of hard tissue regeneration by using 3D biomaterials obtained by nature-inspired approaches. The main focus is given to porous hydroxyapatitebased ceramic or hybrid scaffolds for regeneration of bone and osteochondral tissues in neurosurgery and orthopedics.

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Osteointegration in Cranial Bone Reconstruction: A Goal to Achieve

Cited by 20 publications

References 36 publications

Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study

Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study

Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

Nature-Inspired Processes and Structures: New Paradigms to Develop Highly Bioactive Devices for Hard Tissue Regeneration

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