Osteointegration in Custom-made Porous Hydroxyapatite Cranial Implants: From Reconstructive Surgery to Regenerative Medicine

Fricia, Marco; Passanisi, Maurizio; Salamanna, Francesca; Parrilli, Annapaola; Giavaresi, Gianluca; Fini, Milena

doi:10.1016/j.wneu.2015.03.027

Cited by 30 publications

(14 citation statements)

References 17 publications

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“…The bone-mimicking features of HA in cranioplasty procedures were also demonstrated in a previous study (28), in which histological changes were observed in a hydroxyapatite plate and granules used to repair a craniotomy defect in a 20-year-old female. The implant was removed after 2 years and 9 months of use, thus revealing complete fusion of the hydroxyapatite plates and granules with the cranium, with new bone formation on the dural side extending in a three-dimensional (3D) matrix along the pores with the Haversian system in the center.…”

Section: Introductionsupporting

confidence: 70%

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Osteointegration in Cranial Bone Reconstruction: A Goal to Achieve

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Fricia

Maddalena

et al. 2016

Journal of Applied Biomaterials & Functional Materials

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Section: Introductionsupporting

confidence: 70%

“…In another study, 2 patients underwent surgical explant of cranial implants after postoperative complications (28). In one case, a 42-year-old female was firstly implanted with a titanium mesh and then, due to wound dehiscence, the implant was removed and replaced with custom-made porous HA (defect size = 120 cm 2 ).…”

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confidence: 99%

Osteointegration in Cranial Bone Reconstruction: A Goal to Achieve

Sprio

Fricia

Maddalena

et al. 2016

Journal of Applied Biomaterials & Functional Materials

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“…The TL approach was chosen because it has three‐dimensional boundaries dictated by the anatomy rather than by the tumor or surgeon, and the volume of bone removal is about three times greater than retrosigmoid approaches (about 30 g, compared to 11 g) . Because the volume of HAC may alter theoretical risks such as bacterial contamination, osteoconduction, and osseointegration, we believe that the TL approach as an inclusion criteria enhances the quality of the study.…”

Section: Discussionmentioning

confidence: 99%

Hydroxyapatite cement cranioplasty following translabyrinthine approach: Long‐term study of 369 cases

et al. 2017

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“…New bone formation in vivo using HAp implants was observed in only 4 cases. [ 4 5 12 ] Information regarding the implant was confirmed in some of the reports,[ 4 5 11 13 15 20 21 ] however, there were only limited descriptions of properties such as porosity and thickness of the artificial implant.…”

Section: Discussionmentioning

confidence: 99%

Histological assessment of porous custom-made hydroxyapatite implants 6 months and 2.5 years after cranioplasty

et al. 2017

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Background:In cranial reconstruction, the features of artificial bone differ. Custom-made porous hydroxyapatite (HAp) implants for cranioplasty have been used all over the world because of their good cosmetic, biocompatibility, and osteoconductive properties. Surgical techniques were analyzed, and histological assessment of new bone formation in the hydroxyapatite was performed.Methods:Over a 6-year time period, 41 patients underwent cranioplasty using a custom-made three-dimensional hybrid pore structured hydroxyapatite (3DHPoHAp) implant. The surgical techniques and histological evaluations of 3DHPoHAp in 2 cases, removed 6 months and 2.5 years after cranioplasty, are described.Results:Using 3DHPoHAp, cranioplasty was successfully performed for all patients. The implant fit the bone defect exactly, and surgical manoeuvres were simple and easy. All implants were firmly fixed using a titanium plate, and postoperative infection occurred in 1 patient (2.4%). New bone formation was seen in 2 cases 6 months and 2.5 years after cranioplasty. Osteoblasts were progressing to the stoma at various depths, and bone tissue had ripened. Furthermore, lamellar structure was observed in the case at 2.5 years.Conclusions:In this study, there was a low infection rate, and new bone formation was seen in vivo after cranioplasty. This study also demonstrated that the 3DHPoHAp implant is a good candidate for cranial bone implants because its good osteoconductivity and biocompatibility.

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Osteointegration in Custom-made Porous Hydroxyapatite Cranial Implants: From Reconstructive Surgery to Regenerative Medicine

Cited by 30 publications

References 17 publications

Osteointegration in Cranial Bone Reconstruction: A Goal to Achieve

Osteointegration in Cranial Bone Reconstruction: A Goal to Achieve

Hydroxyapatite cement cranioplasty following translabyrinthine approach: Long‐term study of 369 cases

Histological assessment of porous custom-made hydroxyapatite implants 6 months and 2.5 years after cranioplasty

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